2005
Modeling premature aging syndromes with the telomerase knockout mouse.
Chang S. Modeling premature aging syndromes with the telomerase knockout mouse. 2005, 5: 153-8. PMID: 15974868, DOI: 10.2174/1566524053586662.Peer-Reviewed Original ResearchMeSH KeywordsAging, PrematureAnimalsDisease Models, AnimalMiceMice, KnockoutMutationSyndromeTelomeraseConceptsTelomerase knockout miceMammalian agingGenomic instabilityDNA damage pathwayPremature aging syndromesCellular declineMolecular basisAging syndromesAging processDamage pathwayKnockout miceMolecular pathwaysShort telomeresHuman agingPrimate model systemMouse modelModel systemBiological mechanismsPhenotypePhysiological changesPathwayUnprecedented opportunityDeleterious effectsTelomeresMice
2004
A mouse model of Werner Syndrome: what can it tell us about aging and cancer?
Chang S. A mouse model of Werner Syndrome: what can it tell us about aging and cancer? The International Journal Of Biochemistry & Cell Biology 2004, 37: 991-999. PMID: 15743673, DOI: 10.1016/j.biocel.2004.11.007.Peer-Reviewed Original ResearchMeSH KeywordsAging, PrematureAnimalsDisease Models, AnimalHumansMiceMice, TransgenicNeoplasmsTelomereWerner SyndromeConceptsMolecular mechanismsWerner syndromePremature agingConsequent cellular responsesGene functionMammalian agingDysfunctional telomeresGenetic pathwaysReplicative senescenceTelomere dysfunctionCellular responsesGenetic platformProgeroid syndromesMolecular levelMouse modelRecent studiesAging processTelomeresSenescenceTumorigenesisPathwayMechanismAgingCancerSyndromeEssential role of limiting telomeres in the pathogenesis of Werner syndrome
Chang S, Multani AS, Cabrera NG, Naylor ML, Laud P, Lombard D, Pathak S, Guarente L, DePinho RA. Essential role of limiting telomeres in the pathogenesis of Werner syndrome. Nature Genetics 2004, 36: 877-882. PMID: 15235603, DOI: 10.1038/ng1389.Peer-Reviewed Original ResearchConceptsWerner syndromeCultured cellsComplex cellular phenotypesElevated genomic instabilityDNA damage fociPremature aging syndromesWRN deficiencyReplicative senescenceCellular phenotypesGenomic instabilityAging syndromesGenetic dataMutational inactivationPremature senescenceChromosomal instabilityTelomerase expressionHair grayingPremature agingDisease phenotypeEssential roleWRNMice nullSenescenceAutosomal recessive diseaseType II diabetes