2005
Modeling aging and cancer in the telomerase knockout mouse
Chang S. Modeling aging and cancer in the telomerase knockout mouse. Mutation Research/Fundamental And Molecular Mechanisms Of Mutagenesis 2005, 576: 39-53. PMID: 15927211, DOI: 10.1016/j.mrfmmm.2004.08.020.Peer-Reviewed Original ResearchConceptsTelomere dysfunctionRole of telomeresTelomerase-null miceTelomerase knockout miceTelomerase-deficient miceOrganismal agingSomatic cellsMammalian organismsTight regulationCellular responsesTelomerase activityNull miceKnockout miceTelomeresMouse modelTelomeraseOrganismsMiceDeficient miceRegulationAgingCellsCancer
2000
Inhibition of Experimental Liver Cirrhosis in Mice by Telomerase Gene Delivery
Rudolph K, Chang S, Millard M, Schreiber-Agus N, DePinho R. Inhibition of Experimental Liver Cirrhosis in Mice by Telomerase Gene Delivery. Science 2000, 287: 1253-1258. PMID: 10678830, DOI: 10.1126/science.287.5456.1253.Peer-Reviewed Original ResearchConceptsLiver cirrhosisChronic diseasesEnd-stage organ failureChronic liver injuryImproved liver functionExperimental liver cirrhosisLiver injuryOrgan failureLiver functionTelomerase-deficient miceTelomere dysfunctionHigh cellular turnoverTelomerase therapyChemical ablationCirrhosisAdenoviral deliveryLiver regenerationSuch diseasesDiseaseMiceTelomerase activityDysfunctionLiverCellular turnoverShort dysfunctional telomeres