2008
Initiation of Genomic Instability, Cellular Senescence, and Organismal Aging by Dysfunctional Telomeres
Chang S. Initiation of Genomic Instability, Cellular Senescence, and Organismal Aging by Dysfunctional Telomeres. 2008, 57-75. DOI: 10.1007/978-3-540-73709-4_4.Peer-Reviewed Original ResearchDysfunctional telomeresOrganismal agingCellular senescenceDNA damage responseLinear chromosomesShelterin complexDamage responseTelomeric repeatsGenomic instabilityTelomeric structureTelomeresSenescenceFunction resultsProteinImportant roleChromosomesMouse modelRepeatsTelomeraseDNAProgressive lossP53ActivationComplexesAging
2007
Role of telomeres and telomerase in genomic instability, senescence and cancer
Deng Y, Chang S. Role of telomeres and telomerase in genomic instability, senescence and cancer. Laboratory Investigation 2007, 87: 1071-1076. PMID: 17767195, DOI: 10.1038/labinvest.3700673.Peer-Reviewed Original ResearchConceptsHuman cancersAnti-telomerase therapyAttractive therapeutic targetClinical trialsTherapeutic targetDNA damage responseRole of telomeresAbsence of p53Progressive lossHuman carcinomasSuppress tumorigenesisCancerLinear chromosomesCellular senescenceDamage responseTelomeric repeatsDysfunctional telomeresGenomic instabilityTelomeric structureChromosomal instabilityTelomeresP53TelomeraseImportant mechanismFunction results