2022
Joint EANM/SIOPE/RAPNO practice guidelines/SNMMI procedure standards for imaging of paediatric gliomas using PET with radiolabelled amino acids and [18F]FDG: version 1.0
Piccardo A, Albert N, Borgwardt L, Fahey F, Hargrave D, Galldiks N, Jehanno N, Kurch L, Law I, Lim R, Lopci E, Marner L, Morana G, Young Poussaint T, Seghers V, Shulkin B, Warren K, Traub-Weidinger T, Zucchetta P. Joint EANM/SIOPE/RAPNO practice guidelines/SNMMI procedure standards for imaging of paediatric gliomas using PET with radiolabelled amino acids and [18F]FDG: version 1.0. European Journal Of Nuclear Medicine And Molecular Imaging 2022, 49: 3852-3869. PMID: 35536420, PMCID: PMC9399211, DOI: 10.1007/s00259-022-05817-6.Peer-Reviewed Original ResearchConceptsAmino acid positron emission tomographyPositron emission tomographyPaediatric neuro-oncologyEuropean Society for Paediatric Oncology (SIOPENeuro-oncologyLevel of evidenceBrain tumor groupPositron emission tomography imagingEvidence-based recommendationsPaediatric patientsTumor groupResponse assessmentClinician guidelinesPaediatric gliomasBrain gliomasImaging specialistsEmission tomographyRadiolabeled amino acidsConsensus opinionEANMPaediatric oncologyPET radiopharmaceuticalsGliomaNuclear medicineOncology
2021
Detecting lumbar lesions in 99mTc‐MDP SPECT by deep learning: Comparison with physicians
Petibon Y, Fahey F, Cao X, Levin Z, Sexton‐Stallone B, Falone A, Zukotynski K, Kwatra N, Lim R, Bar‐Sever Z, Chemli Y, Treves S, Fakhri G, Ouyang J. Detecting lumbar lesions in 99mTc‐MDP SPECT by deep learning: Comparison with physicians. Medical Physics 2021, 48: 4249-4261. PMID: 34101855, DOI: 10.1002/mp.15033.Peer-Reviewed Original ResearchConceptsSingle-photon emission computed tomographyLow back painLumbar lesionsPediatric patientsTc-MDPEvaluate low back painCause of low back painTc-MDP scanLesion-presentEmission computed tomographyConvolutional neural networkClinical likelihoodBack painInterreader variabilityDeep convolutional neural networkLumbar locationLesionsStress lesionsFocal lesionsDeep learningPatientsLumbar stressPhysiciansDL systemsLROC studiesValidation of the Radiographic Global Impression of Change (RGI-C) score to assess healing of rickets in pediatric X-linked hypophosphatemia (XLH)
Lim R, Shailam R, Hulett R, Skrinar A, Nixon A, Williams A, Nixon M, Thacher T. Validation of the Radiographic Global Impression of Change (RGI-C) score to assess healing of rickets in pediatric X-linked hypophosphatemia (XLH). Bone 2021, 148: 115964. PMID: 33878504, DOI: 10.1016/j.bone.2021.115964.Peer-Reviewed Original ResearchConceptsRickets Severity ScaleInter-rater reliabilityGlobal Impression of ChangeX-linked hypophosphatemiaIntra-raterImpression of ChangeRadiographic Global Impression of ChangeGlobal scoreRGI-CModerate to almost perfect agreementStandardized response meanIntra-rater reliabilityAlmost perfect agreementWeighted kappa valuesResponse meanChange scoresStanding heightBaseline to weekLeg scoreHealing of ricketsSeverity ScalePerfect agreementRickets severityBurosumab treatmentKappa values
2020
Reducing Radiation Dose and Contrast Medium Volume With Application of Dual-Energy CT in Children and Young Adults.
Tabari A, Gee M, Singh R, Lim R, Nimkin K, Primak A, Schmidt B, Kalra M. Reducing Radiation Dose and Contrast Medium Volume With Application of Dual-Energy CT in Children and Young Adults. American Journal Of Roentgenology 2020, 214: 1199-1205. PMID: 32286868, DOI: 10.2214/ajr.19.22231.Peer-Reviewed Original ResearchConceptsSingle-energy CTContrast material volumeDS-DECTDual-energy CTRadiation doseThird-generation dual-source CT scannerDual-source dual-energy CTDual-source CT scannerContrast volume reductionCT dose descriptorsMean patient ageApplications of dual-energy CTContrast medium volumeWeight-matched patientsYoung adultsReduce radiation doseLow radiation doseCohen's kappa testConsecutive childrenPatient ageRadiological findingsDose descriptorsPatient demographicsRetrospective studyKappa test
2019
PET/MR Imaging: Current Updates on Pediatric Applications
Kwatra N, Lim R, Gee M, States L, Vossough A, Lee E. PET/MR Imaging: Current Updates on Pediatric Applications. Magnetic Resonance Imaging Clinics Of North America 2019, 27: 387-407. PMID: 30910104, DOI: 10.1016/j.mric.2019.01.012.Peer-Reviewed Original ResearchClinical significance of incidentally discovered renal cysts in pediatric patients
Botwin A, Phewplung T, Wu K, Lim R, Traum A, Gee M. Clinical significance of incidentally discovered renal cysts in pediatric patients. Abdominal Radiology 2019, 44: 2835-2840. PMID: 30972430, DOI: 10.1007/s00261-019-02017-z.Peer-Reviewed Original ResearchConceptsAutosomal dominant polycystic kidney diseasePediatric patientsRenal cystsFamily historyClinical significanceCyst groupRisk of autosomal dominant polycystic kidney diseaseDiagnosis of autosomal dominant polycystic kidney diseaseAssociated with higher incidenceMethodsA retrospective searchFollow-up imagingDominant polycystic kidney diseaseSearch of radiology reportsMaximum cyst diameterStatistically significant elevationPolycystic kidney diseaseNo malignancyRetrospective search of radiology reportsCyst evaluationBilateral cystsCyst sizeFollow-up studyCyst characteristicsCyst diameterImaging predictors
2018
Artificial intelligence-assisted interpretation of bone age radiographs improves accuracy and decreases variability
Tajmir S, Lee H, Shailam R, Gale H, Nguyen J, Westra S, Lim R, Yune S, Gee M, Do S. Artificial intelligence-assisted interpretation of bone age radiographs improves accuracy and decreases variability. Skeletal Radiology 2018, 48: 275-283. PMID: 30069585, DOI: 10.1007/s00256-018-3033-2.Peer-Reviewed Original ResearchConceptsBone age assessmentAutomated artificial intelligenceAI assistanceBone age radiographsConvolutional neural networkDeep learning algorithmsRoot mean square errorMean square errorPediatric radiologistsUtilization of AILearning algorithmsNeural networkArtificial intelligenceIntraclass correlation coefficientImproved performancePooled cohortRadiologist interpretationImaging studiesInter-rater variationAccuracyMetabolic disordersIncreased accuracyRadiologistsAge accuracyMeasures of accuracy
2016
Up-to-date review of nuclear medicine applications in pediatric thoracic imaging
Kwatra N, Grant F, Lim R, Lee E. Up-to-date review of nuclear medicine applications in pediatric thoracic imaging. European Journal Of Radiology 2016, 95: 418-427. PMID: 27142495, DOI: 10.1016/j.ejrad.2016.04.007.Peer-Reviewed Original Research
2015
Review of Ingested and Aspirated Foreign Bodies in Children and Their Clinical Significance for Radiologists
Pugmire B, Lim R, Avery L. Review of Ingested and Aspirated Foreign Bodies in Children and Their Clinical Significance for Radiologists. Radio Graphics 2015, 35: 1528-1538. PMID: 26295734, DOI: 10.1148/rg.2015140287.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsBronchoscopyCausticsChildChild, PreschoolEatingEmergenciesEndoscopy, Digestive SystemEsophagusForeign BodiesGastrointestinal TractGlassHumansInfantIntestinal ObstructionIntestinal PerforationMagnetsMetalsNumismaticsRadiographyRespiratory AspirationRespiratory SystemUnited StatesConceptsAspirated foreign bodyForeign bodyClinical managementClinical significanceIngested foreign bodiesRisk of esophageal injuryImaging appearanceAggressive clinical managementForeign body aspirationExamination of childrenEsophageal injuryBowel perforationFistula formationPrompt recognitionImaging examinationsPediatric populationClinical symptomsComputed tomographyAppropriate treatmentHigh riskPrompt identificationBowel wallRadiologistsGastrointestinal tractClinical implicationsSimplifying size-specific radiation dose estimates in pediatric CT.
Khawaja R, Singh S, Vettiyil B, Lim R, Gee M, Westra S, Kalra M. Simplifying size-specific radiation dose estimates in pediatric CT. American Journal Of Roentgenology 2015, 204: 167-76. PMID: 25539253, DOI: 10.2214/ajr.13.12191.Peer-Reviewed Original ResearchConceptsSize-specific dose estimateStatistically significant correlationDose estimatesBody weightTorso diameterSize-specific doseConsecutive CT examinationsMedian body weightPatient's body weightRadiation dose estimatesSignificant correlationPediatric CTCT examinationsEffective diameterIndividual patientsOverall body weightClinical settingPatientsDoseD(apChildrenAutomated softwareMeasured diameterBodyManual measurements
2014
Dose reduction in pediatric abdominal CT: use of iterative reconstruction techniques across different CT platforms
Khawaja R, Singh S, Otrakji A, Padole A, Lim R, Nimkin K, Westra S, Kalra M, Gee M. Dose reduction in pediatric abdominal CT: use of iterative reconstruction techniques across different CT platforms. Pediatric Radiology 2014, 45: 1046-1055. PMID: 25427434, DOI: 10.1007/s00247-014-3235-2.Peer-Reviewed Original ResearchConceptsIterative reconstruction techniqueSinogram-affirmed iterative reconstructionAdaptive statistical iterative reconstructionModel-based iterative reconstructionPediatric abdominal CTDose reductionIterative reconstructionAbdominal CTAdaptive iterative dose reductionMagnitude of dose reductionIncreased image noiseStatistical iterative reconstructionAIDR 3DReconstruction techniqueCT examinationsCT scanImage noiseReconstruction algorithmClinical settingDosing potentialClinical applicationImage qualityRadiology communityReconstruction principleImage interpretation
2010
Brown adipose tissue 18F-FDG uptake in pediatric PET/CT imaging
Hong T, Shammas A, Charron M, Zukotynski K, Drubach L, Lim R. Brown adipose tissue 18F-FDG uptake in pediatric PET/CT imaging. Pediatric Radiology 2010, 41: 759-768. PMID: 21161205, DOI: 10.1007/s00247-010-1925-y.Peer-Reviewed Original Research
2009
Pediatric FDG PET/CT: Physiologic Uptake, Normal Variants, and Benign Conditions1
Shammas A, Lim R, Charron M. Pediatric FDG PET/CT: Physiologic Uptake, Normal Variants, and Benign Conditions1. Radio Graphics 2009, 29: 1467-86. PMID: 19755606, DOI: 10.1148/rg.295085247.Peer-Reviewed Original ResearchConceptsPositron emission tomographyFDG uptakeBenign lesionsPhysiological uptakeIncreased (18)F-FDG uptakeFDG-PET/CT studiesPhysiological variantsHead and neckAssociated with pitfallsUrinary collecting systemPediatric oncology patientsPET/CT studiesFollow-up studyPET/computed tomographicBone marrowImprove patient treatmentOncology patientsNormal variantsPET image interpretationEmission tomographyPatient treatmentAttenuation correctionAdipose tissueBrown adipose tissueGastrointestinal tract
2007
Early Experience With Fluorine-18 Sodium Fluoride Bone PET in Young Patients With Back Pain
Lim R, Fahey F, Drubach L, Connolly L, Treves S. Early Experience With Fluorine-18 Sodium Fluoride Bone PET in Young Patients With Back Pain. Journal Of Pediatric Orthopaedics 2007, 27: 277-282. PMID: 17414009, DOI: 10.1097/bpo.0b013e31803409ba.Peer-Reviewed Original ResearchConceptsPositron emission tomographyBack painYounger patientsPotential sources of back painSource of back painFluorine-18Evaluating young patientsRadiation dosimetryNaF PET scanEnhanced patient throughputPET scansApophyseal injuriesPainTechnetium-99Tracer administrationPatientsRadiation doseSkeletal abnormalitiesPET acquisitionEmission tomographySodium fluorideScintigraphyNinety-fourPatient throughputDosimetry