2022
Human biodistribution and radiation dosimetry of the demyelination tracer [18F]3F4AP
Brugarolas P, Wilks M, Noel J, Kaiser J, Vesper D, Ramos-Torres K, Guehl N, Macdonald-Soccorso M, Sun Y, Rice P, Yokell D, Lim R, Normandin M, El Fakhri G. Human biodistribution and radiation dosimetry of the demyelination tracer [18F]3F4AP. European Journal Of Nuclear Medicine And Molecular Imaging 2022, 50: 344-351. PMID: 36197499, PMCID: PMC9816249, DOI: 10.1007/s00259-022-05980-w.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDemyelinating DiseasesFemaleHumansMalePositron-Emission TomographyRadiometryRadiopharmaceuticalsTissue DistributionConceptsRadiation dosimetryTime-activity curvesAdverse eventsEffective doseMultiple bed positionsComprehensive metabolic panelNonhuman primatesHealthy human volunteersNo adverse eventsDynamic PET scansVoltage-gated potassiumAnimal models of neurological diseasesNonhuman primate studiesModels of neurological diseasesHuman biodistributionAverage effective doseMetabolic panelDosimetryOLINDA softwareHealthy volunteersUrinary bladderPET scansDemyelinating lesionsBed positionAnimal modelsJoint EANM/SIOPE/RAPNO practice guidelines/SNMMI procedure standards for imaging of paediatric gliomas using PET with radiolabelled amino acids and [18F]FDG: version 1.0
Piccardo A, Albert N, Borgwardt L, Fahey F, Hargrave D, Galldiks N, Jehanno N, Kurch L, Law I, Lim R, Lopci E, Marner L, Morana G, Young Poussaint T, Seghers V, Shulkin B, Warren K, Traub-Weidinger T, Zucchetta P. Joint EANM/SIOPE/RAPNO practice guidelines/SNMMI procedure standards for imaging of paediatric gliomas using PET with radiolabelled amino acids and [18F]FDG: version 1.0. European Journal Of Nuclear Medicine And Molecular Imaging 2022, 49: 3852-3869. PMID: 35536420, PMCID: PMC9399211, DOI: 10.1007/s00259-022-05817-6.Peer-Reviewed Original ResearchMeSH KeywordsAmino AcidsChildFluorodeoxyglucose F18GliomaHumansPositron-Emission TomographyRadiopharmaceuticalsConceptsAmino acid positron emission tomographyPositron emission tomographyPaediatric neuro-oncologyEuropean Society for Paediatric Oncology (SIOPENeuro-oncologyLevel of evidenceBrain tumor groupPositron emission tomography imagingEvidence-based recommendationsPaediatric patientsTumor groupResponse assessmentClinician guidelinesPaediatric gliomasBrain gliomasImaging specialistsEmission tomographyRadiolabeled amino acidsConsensus opinionEANMPaediatric oncologyPET radiopharmaceuticalsGliomaNuclear medicineOncology
2020
SNMMI Procedure Standard/EANM Practice Guideline on Pediatric 18F-FDG PET/CT for Oncology 1.0
Vali R, Alessio A, Balza R, Borgwardt L, Bar-Sever Z, Czachowski M, Jehanno N, Kurch L, Pandit-Taskar N, Parisi M, Piccardo A, Seghers V, Shulkin B, Zucchetta P, Lim R. SNMMI Procedure Standard/EANM Practice Guideline on Pediatric 18F-FDG PET/CT for Oncology 1.0. Journal Of Nuclear Medicine 2020, 62: 99-110. PMID: 33334912, PMCID: PMC8679588, DOI: 10.2967/jnumed.120.254110.Peer-Reviewed Original ResearchConceptsEuropean Association of Nuclear MedicineF-FDG PET/CTF-FDGComputerized tomographyTechnology subsequent to publicationEvidence-based recommendationsLevel of trainingNuclear medicineLevel of evidenceDiagnostic nuclear medicine imagingPractice of medicineComplexity of human conditionsMedicine careStandard of careScience of nuclear medicineLegal standard of careCourse of actionMedicine practiceConsensus processPractice guidelinesSociety of Nuclear MedicinePediatric oncologyMedical professionalsClinician guidelinesApplications of nuclear medicine
2015
Synergistic role of simultaneous PET/MRI-MRS in soft tissue sarcoma metabolism imaging
Zhang X, Chen Y, Lim R, Huang C, Chebib I, Fakhri G. Synergistic role of simultaneous PET/MRI-MRS in soft tissue sarcoma metabolism imaging. Magnetic Resonance Imaging 2015, 34: 276-279. PMID: 26523656, PMCID: PMC4761342, DOI: 10.1016/j.mri.2015.10.027.Peer-Reviewed Original ResearchConceptsSoft tissue sarcomasMagnetic resonance imagingHigh (18)F-FDG uptakeT2 hyperintense massMagnetic resonance spectroscopyNeoadjuvant radiotherapyPathological resultsTumor marginsTissue sarcomasImaging findingsPET/MRI scansPET scansRight thighRadiotherapyNormal tissuesEmission tomographyResonance imagingMetabolite profilesSarcomaPET/MRIChemoRTChemoradiationSynergistic rolePETSurgery
2014
[18F]-Fluoromisonidazole Positron Emission Tomography/Computed Tomography Visualization of Tumor Hypoxia in Patients With Chordoma of the Mobile and Sacrococcygeal Spine
Cheney M, Chen Y, Lim R, Winrich B, Grosu A, Trofimov A, Depauw N, Shih H, Schwab J, Hornicek F, DeLaney T. [18F]-Fluoromisonidazole Positron Emission Tomography/Computed Tomography Visualization of Tumor Hypoxia in Patients With Chordoma of the Mobile and Sacrococcygeal Spine. International Journal Of Radiation Oncology • Biology • Physics 2014, 90: 1030-1036. PMID: 25539367, PMCID: PMC4280072, DOI: 10.1016/j.ijrobp.2014.08.016.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedCell HypoxiaChordomaFeasibility StudiesFemaleHumansMaleMiddle AgedMisonidazoleMultimodal ImagingNeoplasm Recurrence, LocalPhotonsPilot ProjectsPositron-Emission TomographyProspective StudiesProton TherapyRadiopharmaceuticalsRadiotherapy DosageRelative Biological EffectivenessSacrococcygeal RegionSpinal NeoplasmsTomography, X-Ray ComputedTumor BurdenConceptsHypoxic subvolumesGross tumor volumeFMISO PET/CTRadiation therapyLocal recurrenceTumor volumeSacrococcygeal spinePositron emission tomography/computed tomographyRT dose escalationStage T2 tumorsEmission tomography/computed tomographyStandardized uptake valueMedian follow-upTreatment of chordomasChanges to treatmentVisualization of tumor hypoxiaDose escalationT2 tumorsTomography/computed tomographyMetastatic diseaseRecurrent chordomaUptake valueClinical characteristicsTumor hypoxiaFollow-upImproving Concordance of MRI and PET/CT Interpretations With Retrospectively Coregistered MRI and PET/CT Data Sets
Wang Y, Lim R, Khawaja R, Blake M. Improving Concordance of MRI and PET/CT Interpretations With Retrospectively Coregistered MRI and PET/CT Data Sets. Current Problems In Diagnostic Radiology 2014, 44: 232-236. PMID: 25745822, DOI: 10.1067/j.cpradiol.2014.11.004.Peer-Reviewed Original ResearchConceptsConcordance of MRIEvidence of metastatic diseaseMRI scansInstitutional review board approvalPelvic MRI scanImaging follow-upInstitutional electronic medical record systemReview board approvalInterpretation of MRIPET/CT interpretationMetastatic diseasePET/computed tomographyDiscordant lesionsMRI findingsRetrospective studyMRI reportsBoard approvalPET/CTFollow-upDiscordant findingsLesion characterizationBone sitesClinical reportsSoftware fusionPairs of scans
2010
Brown adipose tissue 18F-FDG uptake in pediatric PET/CT imaging
Hong T, Shammas A, Charron M, Zukotynski K, Drubach L, Lim R. Brown adipose tissue 18F-FDG uptake in pediatric PET/CT imaging. Pediatric Radiology 2010, 41: 759-768. PMID: 21161205, DOI: 10.1007/s00247-010-1925-y.Peer-Reviewed Original Research
2009
Pediatric FDG PET/CT: Physiologic Uptake, Normal Variants, and Benign Conditions1
Shammas A, Lim R, Charron M. Pediatric FDG PET/CT: Physiologic Uptake, Normal Variants, and Benign Conditions1. Radio Graphics 2009, 29: 1467-86. PMID: 19755606, DOI: 10.1148/rg.295085247.Peer-Reviewed Original ResearchConceptsPositron emission tomographyFDG uptakeBenign lesionsPhysiological uptakeIncreased (18)F-FDG uptakeFDG-PET/CT studiesPhysiological variantsHead and neckAssociated with pitfallsUrinary collecting systemPediatric oncology patientsPET/CT studiesFollow-up studyPET/computed tomographicBone marrowImprove patient treatmentOncology patientsNormal variantsPET image interpretationEmission tomographyPatient treatmentAttenuation correctionAdipose tissueBrown adipose tissueGastrointestinal tract
2008
Renal pyramid echogenicity in ureteropelvic junction obstruction: correlation between altered echogenicity and differential renal function
Chavhan G, Daneman A, Moineddin R, Lim R, Langlois V, Traubici J. Renal pyramid echogenicity in ureteropelvic junction obstruction: correlation between altered echogenicity and differential renal function. Pediatric Radiology 2008, 38: 1068. PMID: 18633607, DOI: 10.1007/s00247-008-0943-5.Peer-Reviewed Original ResearchConceptsDifferential renal functionLoss of corticomedullary differentiationUreteropelvic junction obstructionPoor renal functionCorticomedullary differentiationUreteropelvic junctionRenal functionGroup 1Risk ratioObstructed kidneyGroup 2Increased echogenicityGroup 3Technetium-99m mercaptoacetyltriglycineResultsIn group 1Fisher's exact testAbnormal echogenicityObstructive hydronephrosisExact testTechnetium-99Histological changesRenal pyramidsHigh-frequency transducersEchogenicityPatients