Corticosteroids to prevent kidney scarring in children with a febrile urinary tract infection: a randomized trial
Shaikh N, Shope T, Hoberman A, Muniz G, Bhatnagar S, Nowalk A, Hickey R, Michaels M, Kearney D, Rockette H, Charron M, Lim R, Majd M, Shalaby-Rana E, Kurs-Lasky M, Cohen D, Wald E, Lockhart G, Pohl H, Martin J. Corticosteroids to prevent kidney scarring in children with a febrile urinary tract infection: a randomized trial. Pediatric Nephrology 2020, 35: 2113-2120. PMID: 32556960, PMCID: PMC7529851, DOI: 10.1007/s00467-020-04622-3.Peer-Reviewed Original ResearchConceptsFebrile urinary tract infectionUrinary tract infectionAdjuvant systemic corticosteroidsKidney scarringSystemic corticosteroidsTract infectionsInitiate urinary tract infectionReducing kidney scarringEfficacy of corticosteroidsMethodsChildren aged 2Absolute risk reductionRandomized to corticosteroidsMonths to 6Statistically significant differencePlacebo groupAdjuvant corticosteroidsCorticosteroidsKidney scansPlaceboSignificant differenceAged 2ScarsKidneyInfectionMonths