Chymase cleavage of stem cell factor yields a bioactive, soluble product
Longley B, Tyrrell L, Ma Y, Williams D, Halaban R, Langley K, Lu H, Schechter N. Chymase cleavage of stem cell factor yields a bioactive, soluble product. Proceedings Of The National Academy Of Sciences Of The United States Of America 1997, 94: 9017-9021. PMID: 9256427, PMCID: PMC23007, DOI: 10.1073/pnas.94.17.9017.Peer-Reviewed Original ResearchMeSH KeywordsBinding SitesChymasesHumansHydrolysisMast CellsSerine EndopeptidasesStem Cell FactorSubstrate SpecificityConceptsSoluble SCFCell factorMembrane-bound moleculesMast cell secretory granulesStromal cellsStem cell factorChymotrypsin-like proteaseSCF geneCell secretory granulesC-terminusPossible feedback loopRelevant enzymesNovel siteAmino acidsDifferentiated functionsMast cellsCell proliferationExon 6Secretory granulesHuman mast cell chymaseChronic cutaneous inflammationMast cell chymaseKIT proteinBioactive productsMast cell proliferation