1997
Suppression of autocrine cell proliferation and tumorigenesis of human melanoma cells and fibroblast growth factor transformed fibroblasts by a kinase-deficient FGF receptor 1: evidence for the involvement of Src-family kinases
Yayon A, Ma Y, Safran M, Klagsbrun M, Halaban R. Suppression of autocrine cell proliferation and tumorigenesis of human melanoma cells and fibroblast growth factor transformed fibroblasts by a kinase-deficient FGF receptor 1: evidence for the involvement of Src-family kinases. Oncogene 1997, 14: 2999-3009. PMID: 9223663, DOI: 10.1038/sj.onc.1201159.Peer-Reviewed Original ResearchMeSH Keywords3T3 CellsAnimalsCell DivisionCell Line, TransformedFibroblast Growth Factor 2FibroblastsFilaggrin ProteinsGenes, DominantHumansMelanomaMicePhenotypeProtein-Tyrosine KinasesReceptor Protein-Tyrosine KinasesReceptor, Fibroblast Growth Factor, Type 1Receptors, Fibroblast Growth FactorRecombinant ProteinsSrc Homology DomainsTumor Cells, CulturedConceptsSrc family kinasesFGF receptor 1FGF receptorsTyrosyl-phosphorylated proteinsHuman melanoma cellsMelanoma cellsImmune kinase assayIntracellular kinase domainDominant negative mutantActivated FGF receptorCell proliferationMetastatic melanoma cellsMelanoma tumor progressionGrowth factorTransmembrane domainKinase assaysSrc familyKinase domainDownstream targetsReceptor 1Fibroblast growth factorBasic fibroblast growth factorGrowth advantageNormal melanocytesAutocrine activation
1996
UV-induced ubiquitination of RNA polymerase II: a novel modification deficient in Cockayne syndrome cells.
Bregman D, Halaban R, van Gool A, Henning K, Friedberg E, Warren S. UV-induced ubiquitination of RNA polymerase II: a novel modification deficient in Cockayne syndrome cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 1996, 93: 11586-11590. PMID: 8876179, PMCID: PMC38101, DOI: 10.1073/pnas.93.21.11586.Peer-Reviewed Original Research
1993
Human Melanoma Cells but Not Normal Melanocytes Express Vascular Endothelial Growth Factor Receptors
Gitaygoren H, Halaban R, Neufeld G. Human Melanoma Cells but Not Normal Melanocytes Express Vascular Endothelial Growth Factor Receptors. Biochemical And Biophysical Research Communications 1993, 190: 702-709. PMID: 8439321, DOI: 10.1006/bbrc.1993.1106.Peer-Reviewed Original ResearchMeSH KeywordsCells, CulturedCross-Linking ReagentsEndothelial Growth FactorsHeparinHumansIn Vitro TechniquesLymphokinesMelanocytesMelanomaProtein-Tyrosine KinasesReceptors, MitogenReceptors, Vascular Endothelial Growth FactorRecombinant ProteinsVascular Endothelial Growth Factor AVascular Endothelial Growth FactorsConceptsVascular endothelial growth factorHuman melanoma cellsMelanoma cellsMalignant transformationVEGF receptorsVascular endothelial growth factor receptorEndothelial growth factor receptorNormal melanocytesEndothelial growth factorGrowth factor receptorMelanoma cell linesHeparin-like moleculesAngiogenic factorsEndothelial cellsSpecific mitogenAberrant expressionGrowth factorFactor receptorLigand/receptor interactionsReceptorsMalignant melanocytesRadioactive ligandExogenous heparinPossible involvementReceptor interaction