2004
Automated Quantitative Analysis of HDM2 Expression in Malignant Melanoma Shows Association with Early-Stage Disease and Improved Outcome
Berger AJ, Camp RL, DiVito KA, Kluger HM, Halaban R, Rimm DL. Automated Quantitative Analysis of HDM2 Expression in Malignant Melanoma Shows Association with Early-Stage Disease and Improved Outcome. Cancer Research 2004, 64: 8767-8772. PMID: 15574789, DOI: 10.1158/0008-5472.can-04-1384.Peer-Reviewed Original ResearchConceptsMurine double minute 2Double minute 2Protein expressionMalignant melanomaMinute 2Early-stage diseaseTissue microarray cohortPotential tissue biomarkersCutaneous malignant melanomaValuable prognostic toolNormal skin samplesSkin cancer deathsMicroarray cohortAdvanced melanomaMetastatic lesionsCancer deathPrimary melanomaImproved outcomesExpression of HDM2Tissue biomarkersPrognostic toolBetter outcomesMelanoma lesionsAggressive natureMelanomaHer2/neu is not a commonly expressed therapeutic target in melanoma – a large cohort tissue microarray study
Kluger HM, DiVito K, Berger AJ, Halaban R, Ariyan S, Camp RL, Rimm DL. Her2/neu is not a commonly expressed therapeutic target in melanoma – a large cohort tissue microarray study. Melanoma Research 2004, 14: 207-210. PMID: 15179190, DOI: 10.1097/01.cmr.0000130874.33504.2f.Peer-Reviewed Original ResearchConceptsHER2/neu expressionHER2/neuNeu expressionMelanoma specimensNeu stainingMelanoma patientsLarge cohortPositive HER2/neu expressionChemotherapy-resistant malignancyPrimary cutaneous lesionNumerous new agentsTissue microarray studyMonoclonal antibody trastuzumabAdjuvant therapyCutaneous specimensTrastuzumab therapyMetastatic lesionsBreslow depthClark levelClinicopathological dataCutaneous lesionsPrimary lesionTumor stageMetastatic melanomaBreast cancer
1985
Primary Melanoma Cells of the Vertical Growth Phase: Similarities to Metastatic Cells2
Herlyn M, Balaban G, Bennicelli J, Guerry D, Halaban R, Herlyn D, Elder D, Maul G, Steplewski Z, Nowell P, Clark W, Koprowski H. Primary Melanoma Cells of the Vertical Growth Phase: Similarities to Metastatic Cells2. Journal Of The National Cancer Institute 1985, 74: 283-289. PMID: 3856042, DOI: 10.1093/jnci/74.2.283.Peer-Reviewed Original ResearchConceptsVertical growth phaseMetastatic melanoma cellsMelanoma cellsMetastatic lesionsPrimary melanomaMetastatic cellsMelanoma-associated antigensMixed hemadsorption assaysPrimary melanoma cellsLong-term cultured cellsMetastatic melanoma cell linesGrowth phaseMelanoma cell linesRadial growth phaseMalignant melanomaNude micePopulation-doubling timeNonrandom abnormalitiesFlow cytometryHemadsorption assaysMonoclonal antibodiesMelanomaPatientsCell linesLesions