1997
Chymase cleavage of stem cell factor yields a bioactive, soluble product
Longley B, Tyrrell L, Ma Y, Williams D, Halaban R, Langley K, Lu H, Schechter N. Chymase cleavage of stem cell factor yields a bioactive, soluble product. Proceedings Of The National Academy Of Sciences Of The United States Of America 1997, 94: 9017-9021. PMID: 9256427, PMCID: PMC23007, DOI: 10.1073/pnas.94.17.9017.Peer-Reviewed Original ResearchConceptsSoluble SCFCell factorMembrane-bound moleculesMast cell secretory granulesStromal cellsStem cell factorChymotrypsin-like proteaseSCF geneCell secretory granulesC-terminusPossible feedback loopRelevant enzymesNovel siteAmino acidsDifferentiated functionsMast cellsCell proliferationExon 6Secretory granulesHuman mast cell chymaseChronic cutaneous inflammationMast cell chymaseKIT proteinBioactive productsMast cell proliferation
1995
Mouse silver. mutation is caused by a single base insertion in the putative cytoplasmic domain of Pmel 17
Kwon B, Halaban R, Ponnazhagan S, Kim K, Chintamaneni C, Bennett D, Pickard R. Mouse silver. mutation is caused by a single base insertion in the putative cytoplasmic domain of Pmel 17. Nucleic Acids Research 1995, 23: 154-158. PMID: 7870580, PMCID: PMC306643, DOI: 10.1093/nar/23.1.154.Peer-Reviewed Original ResearchConceptsPmel 17CDNA clonesMelanocyte cDNA libraryPutative cytoplasmic tailPutative cytoplasmic domainAmino acidsMouse chromosome 10Coat color locusSingle nucleotide insertionSilver locusSingle base insertionChromosomal locationGenomic regionsCytoplasmic domainTermination signalCytoplasmic tailCDNA libraryReading frameSI allelesColor locusCarboxyl terminusC-terminusChromosome 10Nucleotide insertionBase insertion
1994
Characterization of Mouse Pmel 17 Gene and Silver Locus
KWON B, KIM K, HALABAN R, PICKARD R. Characterization of Mouse Pmel 17 Gene and Silver Locus. Pigment Cell & Melanoma Research 1994, 7: 394-397. PMID: 7761347, DOI: 10.1111/j.1600-0749.1994.tb00067.x.Peer-Reviewed Original ResearchConceptsCDNA clonesPutative cytoplasmic tailPmel 17Amino acidsC-terminal amino acidsSingle nucleotide insertionSilver locusGenomic regionsCytoplasmic tailCarboxyl terminusC-terminusMurine melanocytesNucleotide insertionMutation sitesProteinClonesGenesTerminusLociMajor defectsMutationsResiduesAcidMelanocytesInsertion