2024
Nutrient-derived signals regulate eosinophil adaptation to the small intestine
Kutyavin V, Korn L, Medzhitov R. Nutrient-derived signals regulate eosinophil adaptation to the small intestine. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2316446121. PMID: 38271336, PMCID: PMC10835075, DOI: 10.1073/pnas.2316446121.Peer-Reviewed Original ResearchConceptsRetinoic acid signalingCrypt-villus axisLocalization signalTissue-specific adaptationsAcid signalingAmino acidsFunctional significanceTranscriptional signatureHomeostatic conditionsSmall intestineTissue microenvironmentType 2 immunityPurified amino acidsSignalAccumulationEffector cellsBone marrowIL-5Eosinophil accumulationSubpopulationsIntestineEffectorAdaptationHigh-protein diet
2020
Longitudinal analyses reveal immunological misfiring in severe COVID-19
Lucas C, Wong P, Klein J, Castro TBR, Silva J, Sundaram M, Ellingson MK, Mao T, Oh JE, Israelow B, Takahashi T, Tokuyama M, Lu P, Venkataraman A, Park A, Mohanty S, Wang H, Wyllie AL, Vogels CBF, Earnest R, Lapidus S, Ott IM, Moore AJ, Muenker MC, Fournier JB, Campbell M, Odio CD, Casanovas-Massana A, Herbst R, Shaw A, Medzhitov R, Schulz W, Grubaugh N, Dela Cruz C, Farhadian S, Ko A, Omer S, Iwasaki A. Longitudinal analyses reveal immunological misfiring in severe COVID-19. Nature 2020, 584: 463-469. PMID: 32717743, PMCID: PMC7477538, DOI: 10.1038/s41586-020-2588-y.Peer-Reviewed Original ResearchConceptsSevere COVID-19Moderate COVID-19Immune signaturesDisease outcomeCOVID-19Disease trajectoriesInterleukin-5Early immune signaturesInnate cell lineagesType 2 effectorsT cell numbersPoor clinical outcomeWorse disease outcomesImmune response profileCoronavirus disease 2019Distinct disease trajectoriesCytokine levelsImmunological correlatesImmune profileClinical outcomesEarly elevationImmune profilingIL-13Immunoglobulin EDisease 2019