2023
SMC5 Plays Independent Roles in Congenital Heart Disease and Neurodevelopmental Disability
O'Brien M, Pryzhkova M, Lake E, Mandino F, Shen X, Karnik R, Atkins A, Xu M, Ji W, Konstantino M, Brueckner M, Ment L, Khokha M, Jordan P. SMC5 Plays Independent Roles in Congenital Heart Disease and Neurodevelopmental Disability. International Journal Of Molecular Sciences 2023, 25: 430. PMID: 38203602, PMCID: PMC10779392, DOI: 10.3390/ijms25010430.Peer-Reviewed Original Research
2018
Abnormalities in Left Ventricular Rotation Are Inherent in Young Children with Repaired Tetralogy of Fallot and Are Independent of Right Ventricular Dilation
Karnik R, Uppu SC, Tozzi M, Doucette J, Lytrivi ID, Geiger M, Klas B, Parness IA, Shenoy R, Rajagopal H, Srivastava S. Abnormalities in Left Ventricular Rotation Are Inherent in Young Children with Repaired Tetralogy of Fallot and Are Independent of Right Ventricular Dilation. Pediatric Cardiology 2018, 39: 1172-1180. PMID: 29644405, DOI: 10.1007/s00246-018-1877-9.Peer-Reviewed Original ResearchConceptsRight ventricular dilationRV dilationAbnormal ARLV systolicPulmonary regurgitationVentricular dilationRotational mechanicsApical rotationYoung childrenAge-matched normal controlsAsymptomatic young childrenLeft ventricular dysfunctionSingle-center studyLV myocardial mechanicsTetralogy of FallotLV rotational mechanicsTwo-dimensional echocardiographyFurther longitudinal studiesLeft ventricular rotationRTOF childrenLack of maturationVentricular dysfunctionDiastolic dysfunctionDiastolic functionClinical outcomes