2023
Left ventricular strain in pediatric patients with bicuspid aortic valves and aortopathy
Frye R, Ittleman B, Shabanova V, Sugeng L, Steele J, Ferdman D, Karnik R. Left ventricular strain in pediatric patients with bicuspid aortic valves and aortopathy. Progress In Pediatric Cardiology 2023, 69: 101636. DOI: 10.1016/j.ppedcard.2023.101636.Peer-Reviewed Original ResearchBicuspid aortic valveLeft ventricular strainVentricular strainGlobal longitudinal strainGlobal circumferential strainAortic valvePediatric patientsEjection fractionLeft ventricle global longitudinal strainLeft ventricular global longitudinal strainBackground Bicuspid aortic valveVentricle global longitudinal strainSingle-center retrospective studyVentricular global longitudinal strainCommon congenital cardiac defectLongitudinal strainCircumferential strainAortic valve replacementNormal ejection fractionPrior cardiac interventionCongenital cardiac defectsYears of agePotential early markerLeft ventricular myocardiumSignificant differences
2022
Systemic ventricular strain is abnormal with elevated BMI in adults with congenital heart disease
Adlakha H, Malik P, Donthula R, Rajagopal H, Kan A, Srivastava S, Karnik R, Shenoy R. Systemic ventricular strain is abnormal with elevated BMI in adults with congenital heart disease. Progress In Pediatric Cardiology 2022, 65: 101467. DOI: 10.1016/j.ppedcard.2021.101467.Peer-Reviewed Original ResearchElevated body mass indexBody mass indexCongenital heart diseaseType of CHDTransthoracic echocardiogramEjection fractionACHD patientsCardiac dysfunctionHeart diseaseCircumferential strainSignificant associationLV end-diastolic volumeSubclinical cardiac changesSubclinical myocardial dysfunctionSubset of patientsLeft ventricular hypertrophyMultivariate logistic regressionEnd-diastolic volumeResults Univariate analysisWilcoxon rank sum testRank sum testMedian GCSLifestyle modificationEchocardiographic markersBackground ObesityLongitudinal Assessment of Global and Regional Left Ventricular Strain in Patients with Multisystem Inflammatory Syndrome in Children (MIS-C)
He M, Leone DM, Frye R, Ferdman DJ, Shabanova V, Kosiv KA, Sugeng L, Faherty E, Karnik R. Longitudinal Assessment of Global and Regional Left Ventricular Strain in Patients with Multisystem Inflammatory Syndrome in Children (MIS-C). Pediatric Cardiology 2022, 43: 844-854. PMID: 34993558, PMCID: PMC8739007, DOI: 10.1007/s00246-021-02796-7.Peer-Reviewed Original ResearchConceptsMIS-C patientsAcute phaseChronic phaseInflammatory syndromeTwo-dimensional speckle tracking echocardiographySubclinical myocardial injuryCircumferential strainMultisystem inflammatory syndromeLeft ventricular dysfunctionSingle-institution reviewSpeckle tracking echocardiographyTwo-dimensional echocardiographyCoronavirus disease 2019Future adverse eventsVentricular function parametersBasal anterolateral segmentMean GCSVentricular dysfunctionAdverse eventsFractional shorteningSignificant sequelaeVentricular strainMyocardial dysfunctionGlobal longitudinalMyocardial injury