Cardiac Manifestations of Noonan Syndrome.
Karnik R, Geiger M. Cardiac Manifestations of Noonan Syndrome. Pediatric Endocrinology Reviews : PER 2019, 16: 471-476. PMID: 31115199, DOI: 10.17458/per.vol16.2019.kpg.manifestationsnoonan.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsLong-term prognosisDevelopment of cardiomyopathyCommon structural abnormalityPulmonary stenosisCardiac manifestationsMedical therapyTerm prognosisCardiovascular abnormalitiesHypertrophic cardiomyopathyCardiac diseaseCardiac pathologyStructural abnormalitiesRAF1 mutationsNoonan syndromePTPN11 mutationsInvolved pathwaysCardiomyopathyGenotype-phenotype associationsAbnormalitiesWide spectrumAssociationStenosisPrognosisSyndromeInfants