2018
A dormant TIL phenotype defines non-small cell lung carcinomas sensitive to immune checkpoint blockers
Gettinger SN, Choi J, Mani N, Sanmamed MF, Datar I, Sowell R, Du VY, Kaftan E, Goldberg S, Dong W, Zelterman D, Politi K, Kavathas P, Kaech S, Yu X, Zhao H, Schlessinger J, Lifton R, Rimm DL, Chen L, Herbst RS, Schalper KA. A dormant TIL phenotype defines non-small cell lung carcinomas sensitive to immune checkpoint blockers. Nature Communications 2018, 9: 3196. PMID: 30097571, PMCID: PMC6086912, DOI: 10.1038/s41467-018-05032-8.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAntibodies, BlockingCarcinogenesisCarcinoma, Non-Small-Cell LungCell ProliferationCytotoxicity, ImmunologicHistocompatibility Antigens Class IHumansLung NeoplasmsLymphocyte ActivationLymphocytes, Tumor-InfiltratingMaleMice, Inbred NODMice, SCIDMutant ProteinsMutationPeptidesPhenotypeProgrammed Cell Death 1 ReceptorReproducibility of ResultsSurvival AnalysisTobaccoConceptsImmune checkpoint blockersCheckpoint blockersQuantitative immunofluorescenceNon-small cell lung carcinoma patientsCell lung carcinoma patientsNon-small cell lung carcinomaPatient-derived xenograft modelsIntratumoral T cellsMultiplexed quantitative immunofluorescencePD-1 blockadeLevels of CD3Lung carcinoma patientsCell lung carcinomaT cell proliferationPre-treatment samplesTIL phenotypeSurvival benefitCarcinoma patientsEffector capacityLung carcinomaT cellsWhole-exome DNA sequencingXenograft modelFavorable responseBlockers
2014
AACR Celebrates 50 Years of Tobacco Research and Policy
Herbst RS, Hobin JA, Gritz ER, Tobacco and Cancer W. AACR Celebrates 50 Years of Tobacco Research and Policy. Clinical Cancer Research 2014, 20: 1709-1718. PMID: 24691637, DOI: 10.1158/1078-0432.ccr-14-0427.Peer-Reviewed Original Research
2013
Reducing Tobacco‐Related Cancer Incidence and Mortality: Summary of an Institute of Medicine Workshop
Balogh EP, Dresler C, Fleury ME, Gritz ER, Kean TJ, Myers ML, Nass SJ, Nevidjon B, Toll BA, Warren GW, Herbst RS. Reducing Tobacco‐Related Cancer Incidence and Mortality: Summary of an Institute of Medicine Workshop. The Oncologist 2013, 19: 21-31. PMID: 24304712, PMCID: PMC3903060, DOI: 10.1634/theoncologist.2013-0230.Peer-Reviewed Original Research
2010
Tobacco and Cancer: An American Association for Cancer Research Policy Statement
Viswanath K, Herbst RS, Land SR, Leischow SJ, Shields PG, Tobacco and Cancer W. Tobacco and Cancer: An American Association for Cancer Research Policy Statement. Cancer Research 2010, 70: 3419-3430. PMID: 20388799, DOI: 10.1158/0008-5472.can-10-1087.Peer-Reviewed Original ResearchConceptsTobacco-related cancersTobacco useEvidence-based strategiesTobacco productsTobacco controlNew evidence-based strategiesEffective tobacco control strategiesTobacco-related deathsOncology clinical trialsEvidence-based behavioralFormer tobacco usersTobacco-related diseasesTobacco control programsEvidence-based treatmentsWorld Health Organization Framework ConventionTobacco control strategiesNew tobacco productsPublic healthAmerican AssociationAddictive componentTobacco cessationPharmacological treatmentClinical trialsTobacco usersEffective treatment