The state of cellular differentiation determines the activity of the adenovirus E1A enhancer element: evidence for negative regulation of enhancer function
Herbst RS, Pelletier M, Boczko EM, Babiss LE. The state of cellular differentiation determines the activity of the adenovirus E1A enhancer element: evidence for negative regulation of enhancer function. Journal Of Virology 1990, 64: 161-172. PMID: 2136708, PMCID: PMC249075, DOI: 10.1128/jvi.64.1.161-172.1990.Peer-Reviewed Original ResearchMeSH KeywordsAdenovirus Early ProteinsAdenoviruses, HumanAnimalsBase SequenceCell DifferentiationCell LineCell NucleusDNA-Binding ProteinsEnhancer Elements, GeneticGene ExpressionGene Expression Regulation, ViralGenes, ViralHeLa CellsHumansMolecular Sequence DataMutationOncogene Proteins, ViralPromoter Regions, GeneticRNA, MessengerSuppression, GeneticTranscription, GeneticViral Structural ProteinsConceptsE1A gene transcriptionFetal fibroblast cellsGene transcriptionHepatoma cell lineFibroblast cellsCell phenotypeCell linesLiver hepatocytesRodent hepatocytesRat liver hepatocytesSimilar binding activityFurther suppressionHeLa cellsEnhancer elementsCellsBinding activityHepatocytesViral genomeDifferentiated cellsE1A enhancerNegative regulationCellular differentiationImportant mechanismPhenotypeHigh levels