Application of pharmacodynamic assays in a phase Ia trial of Apo2L/TRAIL in patients with advanced tumors
Pan Y, Xu R, Peach M, Huang C, Branstetter D, Durbin B, Herbst R, Eckhardt G, Mendelson D, Holland P. Application of pharmacodynamic assays in a phase Ia trial of Apo2L/TRAIL in patients with advanced tumors. Journal Of Clinical Oncology 2007, 25: 3535-3535. DOI: 10.1200/jco.2007.25.18_suppl.3535.Peer-Reviewed Original ResearchGenomic DNAApo2L/TRAILRhApo2L/TRAILCaspase-3/7Advanced tumorsApoptotic markersPharmacodynamic assayEffector caspase 3/7TRAIL activityCaspase 3/7 levelsDeath inducingRecombinant human Apo2L/TRAILLigand bindingActive caspase-3Phase Ia studyReal-time PCRCellular apoptosisReceptors DR4Caspase-3Patient serum samplesTaqMan real-time PCRColo205 tumorsSerum 8M30 ELISASarcoma patients