2007
First-in-human study of AMG 655, a pro-apoptotic TRAIL receptor-2 agonist, in adult patients with advanced solid tumors
LoRusso P, Hong D, Heath E, Kurzrock R, Wang D, Hsu M, Goyal L, Wiezorek J, Storgard C, Herbst R. First-in-human study of AMG 655, a pro-apoptotic TRAIL receptor-2 agonist, in adult patients with advanced solid tumors. Journal Of Clinical Oncology 2007, 25: 3534-3534. DOI: 10.1200/jco.2007.25.18_suppl.3534.Peer-Reviewed Original ResearchNon-small cell lung cancerMetabolic partial responseAdvanced solid tumorsPartial responseStable diseaseColorectal cancerHuman studiesSolid tumorsMaximum standardized uptake valueDose-linear kineticsElevated serum lipaseSequential dose cohortsOnly grade 3Cell lung cancerReceptor 2 agonistStandardized uptake valueHuman monoclonal agonist antibodyMonoclonal agonist antibodyAnti-tumor activitySensitive tumor cellsTumor response dataSerious AEsDose cohortsProgressive diseaseUnacceptable toxicity
2006
Safety and pharmacokinetics (PK) of AMG 706, panitumumab, and carboplatin/paclitaxel (CP) for the treatment of patients (pts) with advanced non-small cell lung cancer (NSCLC)
Blumenschein G, Sandler A, O’Rourke T, Eschenberg M, Sun Y, Gladish G, Salgia R, Alden C, Herbst R, Reckamp K. Safety and pharmacokinetics (PK) of AMG 706, panitumumab, and carboplatin/paclitaxel (CP) for the treatment of patients (pts) with advanced non-small cell lung cancer (NSCLC). Journal Of Clinical Oncology 2006, 24: 7119-7119. DOI: 10.1200/jco.2006.24.18_suppl.7119.Peer-Reviewed Original ResearchNon-small cell lung cancerAdvanced non-small cell lung cancerCarboplatin/paclitaxelAMG 706Epidermal growth factor receptorDose cohortsStage IIIB/IV non-small cell lung cancerTreatment-related adverse eventsPhase 1b studyAntitumor activityObjective response rateCell lung cancerTreatment of patientsDirect antitumor activityMulti-kinase inhibitorHuman monoclonal antibodyPreliminary dataCNS metastasisGrowth factor receptorPrior chemotherapyQD cohortAdverse eventsMedian ageECOG scoreAcceptable safety