2021
Threshold dose for intravenous nicotine self-administration in young adult non-dependent smokers
MacLean RR, DeVito EE, Eid T, Parida S, Gueorguieva R, Sofuoglu M. Threshold dose for intravenous nicotine self-administration in young adult non-dependent smokers. Psychopharmacology 2021, 238: 2083-2090. PMID: 33796907, PMCID: PMC8715498, DOI: 10.1007/s00213-021-05833-8.Peer-Reviewed Original ResearchConceptsDose of nicotineNicotine reinforcementHigh doseSubjective effectsHuman laboratory studiesYoung adult smokersNicotine self-administration modelNon-dependent smokersOvernight nicotine abstinenceEffects modelSelf-administration modelSelf-administration procedureNicotine doseAdult smokersMethodsYoung adultsObjectivesThe current studyNicotine abstinenceNicotine addictionHigh dosesLow dosesPlaceboThreshold doseReinforcement thresholdTobacco productsDoseThe feasibility of an in‐scanner smoking lapse paradigm to examine the neural correlates of lapses
Lydon‐Staley D, MacLean RR, Falk EB, Bassett DS, Wilson SJ. The feasibility of an in‐scanner smoking lapse paradigm to examine the neural correlates of lapses. Addiction Biology 2021, 26: e13001. PMID: 33508880, PMCID: PMC8225575, DOI: 10.1111/adb.13001.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingFunctional brain systemsCognitive controlBrain systemsDefault mode systemLapse behaviorSmoking cessation attemptFrontoparietal systemNeural correlatesMonetary rewardsBehavioral paradigmsNeural activityInitial evidenceScanning sessionSmoking abstinenceCessation attemptsDaily smokersTime-varying changesSingle scanning sessionQuitting smokingBehavioral modelMagnetic resonance imagingAbstinenceParticipantsParadigm
2020
Naturalistic measurement of dual cue attentional bias in moderate to heavy-drinking smokers: A preliminary investigation
MacLean RR, Sofuoglu M, Waters AJ. Naturalistic measurement of dual cue attentional bias in moderate to heavy-drinking smokers: A preliminary investigation. Drug And Alcohol Dependence 2020, 209: 107892. PMID: 32058247, DOI: 10.1016/j.drugalcdep.2020.107892.Peer-Reviewed Original ResearchConceptsAlcohol attentional biasAttentional biasAlcohol cuesAmbulatory assessmentPossible cognitive mechanismsTask four timesHeavy drinking smokersCognitive mechanismsCue typesDrug cuesPreferential attentionNaturalistic measurementsCuesAlcohol useDaily smokersSubject associationsLarge sampleDaily lifeBiasFurther researchFirst studyPreliminary investigationCravingHeavy amountsCigarettes