2023
Integrating cognitive bias modification for pain and opioid cues into medication for opioid use disorder clinical care: Feasibility, acceptability, and preliminary results
MacLean R, Heapy A, Waters A, Wolkowicz N, Szollosy S, Meyerovich J, Sofuoglu M. Integrating cognitive bias modification for pain and opioid cues into medication for opioid use disorder clinical care: Feasibility, acceptability, and preliminary results. Drug And Alcohol Dependence 2023, 246: 109857. PMID: 37004461, PMCID: PMC10189744, DOI: 10.1016/j.drugalcdep.2023.109857.Peer-Reviewed Original ResearchConceptsTrial-level bias scoresOpioid cuesAB taskCognitive bias modification taskAttentional bias taskCognitive bias modificationComputer-based tasksPreliminary efficacyOpioid use disorderCurrent studyBias modificationBias taskBias scoresModification tasksCBM groupCBM tasksChronic painAcceptability measuresControl conditionTaskUse disordersClinical careCuesTime interactionParticipantsOpioid Use Disorder With Chronic Pain Increases Disease Burden and Service Use
MacLean RR, Sofuoglu M, Stefanovics E, Rosenheck R. Opioid Use Disorder With Chronic Pain Increases Disease Burden and Service Use. Psychological Services 2023, 20: 157-165. PMID: 34968125, PMCID: PMC9358616, DOI: 10.1037/ser0000607.Peer-Reviewed Original ResearchConceptsOpioid use disorderChronic painMental health diagnosesService useUse disordersHealth AdministrationConcurrent opioid use disorderHealth diagnosisOngoing opioid epidemicOutpatient service useVeterans Health AdministrationMental health disordersSubstance use diagnosesSingle disorder groupsClinical service useOpioid prescriptionsAdditional comorbiditiesMultinomial regression analysisDisease burdenMedication fillsOpioid epidemicPrescription opiatesMedical conditionsMedical disordersUse diagnoses
2022
Cocaine Use Disorder (CUD): Current Clinical Perspectives
Schwartz EKC, Wolkowicz NR, De Aquino JP, MacLean RR, Sofuoglu M. Cocaine Use Disorder (CUD): Current Clinical Perspectives. Substance Abuse And Rehabilitation 2022, 13: 25-46. PMID: 36093428, PMCID: PMC9451050, DOI: 10.2147/sar.s337338.Peer-Reviewed Original ResearchCocaine use disorderCo-occurring disordersUse disordersCommon co-occurring disordersCurrent clinical perspectivesSubstance use disordersCognitive behavioral therapyMedication treatmentPharmacological treatmentRisk factorsCurrent treatmentDevastating disorderLarger sample sizeTreatment planChronic effectsCocaine useBehavioral treatmentClinical perspectiveBehavioral interventionsDisordersTreatmentFuture studiesMost individualsIndividualsSample size
2021
A Facility-Wide Plan to Increase Access to Medication for Opioid Use Disorder in Primary Care and General Mental Health Settings.
Spelman JF, Edens EL, Maya S, Moore BA, Boggs A, MacLean RR, Ackland P, Becker WC, Lynch D, Garcia-Vassallo M, Burgo AL, Rosen MI, Gordon AJ. A Facility-Wide Plan to Increase Access to Medication for Opioid Use Disorder in Primary Care and General Mental Health Settings. Federal Practitioner 2021, 38: 460-464. PMID: 34733066, PMCID: PMC8560103, DOI: 10.12788/fp.0186.Peer-Reviewed Original ResearchVeterans Affairs Connecticut Healthcare SystemOpioid use disorderMOUD accessPrimary careTarget clinicsUse disordersGeneral mental health clinicsKey interventionsMental health clinicsMental health settingsGeneral mental health settingsHealth care practitionersQuality improvement effortsElectronic health recordsEligible patientsMOUD receiptPrescriber characteristicsBuprenorphine prescribersOpioid epidemicHealth clinicsMOUDCare practitionersHealth settingsNational VAElectronic consultationTreatment outcomes in individuals diagnosed with comorbid opioid use disorder and Posttraumatic stress disorder: A review
Meshberg-Cohen S, MacLean R, Martin A, Sofuoglu M, Petrakis IL. Treatment outcomes in individuals diagnosed with comorbid opioid use disorder and Posttraumatic stress disorder: A review. Addictive Behaviors 2021, 122: 107026. PMID: 34182307, DOI: 10.1016/j.addbeh.2021.107026.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderComorbid opioid use disorderStress disorderImpact of PTSDPresence of PTSDComorbid posttraumatic stress disorderUse disordersOpioid use disorderMultiple mental health problemsMental health problemsPTSD treatmentComparison participantsTreatment outcomesPTSD diagnosisPsychosocial problemsStandardized assessmentConcurrent diagnosisPsychiatric conditionsMedical record diagnosisDrug useIndividualsDisordersPublic health emergencyRecord diagnosisInclusion criteriaThe Impact of Chronic Pain on Opioid Use Disorder Treatment Outcomes
MacLean R, Spinola S, Garcia-Vassallo G, Sofuoglu M. The Impact of Chronic Pain on Opioid Use Disorder Treatment Outcomes. Current Addiction Reports 2021, 8: 100-108. DOI: 10.1007/s40429-020-00352-6.Peer-Reviewed Original ResearchOpioid agonist treatmentChronic painOpioid use disorderOpioid Use Disorder Treatment OutcomesNonpharmacologic pain treatmentsIllicit opioid useDisorder treatment outcomesReviewChronic painOpioid usePain intensityPain treatmentAgonist treatmentOAT clinicsTreatment outcomesClinical carePainUse disordersDrug useRecent FindingsWeHigher likelihoodClinicOutcomesTreatmentMost studiesIntake
2020
Complex Persistent Opioid Dependence with Long-term Opioids: a Gray Area That Needs Definition, Better Understanding, Treatment Guidance, and Policy Changes
Manhapra A, Sullivan MD, Ballantyne JC, MacLean RR, Becker WC. Complex Persistent Opioid Dependence with Long-term Opioids: a Gray Area That Needs Definition, Better Understanding, Treatment Guidance, and Policy Changes. Journal Of General Internal Medicine 2020, 35: 964-971. PMID: 33159241, PMCID: PMC7728942, DOI: 10.1007/s11606-020-06251-w.Peer-Reviewed Original ResearchConceptsLong-term opioid therapyOpioid taperingOpioid dependenceChronic pain refractoryUtilization of buprenorphineLong-term opioidsSevere chronic painOpioid use disorderMultitude of treatmentsLimited supportive evidenceOpioid therapyPain refractoryBuprenorphine treatmentChronic painClinical instabilityRecent guidelinesClinical definitionUS adultsUse disordersDiagnosis/Treatment guidancePainComplicationsTreatmentSupportive evidenceIntensive Longitudinal Methods for Studying the Role of Self-Regulation Strategies in Substance Use Behavior Change
Roos CR, Kober H, Trull TJ, MacLean RR, Mun CJ. Intensive Longitudinal Methods for Studying the Role of Self-Regulation Strategies in Substance Use Behavior Change. Current Addiction Reports 2020, 7: 301-316. PMID: 33510995, PMCID: PMC7837607, DOI: 10.1007/s40429-020-00329-5.Peer-Reviewed Original ResearchSelf-regulation strategiesIntensive longitudinal methodsSubstance use disordersStrategy usePsychosocial interventionsSelf-regulation strategy useLongitudinal methodsWithin-person levelPersonalization of interventionsCollege student drinkersUse disordersEcological momentary assessmentMechanisms of changeBehavior changeDaily substance useMechanisms of substanceStudent drinkersMomentary assessmentKey next stepDrug use disordersSubstance useMobile interventionsDaily diariesPreliminary evidenceArea of research
2019
Stress and opioid use disorder: A systematic review
MacLean RR, Armstrong JL, Sofuoglu M. Stress and opioid use disorder: A systematic review. Addictive Behaviors 2019, 98: 106010. PMID: 31238237, DOI: 10.1016/j.addbeh.2019.05.034.Peer-Reviewed Original ResearchConceptsOpioid use disorderOpioid useTreatment retentionUse disordersSystematic reviewOUD treatment outcomesIllicit opioid useWarrants further studySignificant clinical concernOUD outcomesStandard treatmentTreatment outcomesDrug counselingPsychopharmacological interventionsClinical concernBehavioral treatmentGreater cravingBehavioral interventionsStudy sampleFurther studiesTreatmentAssessment of stressInterventionImpact of stressMultiple databasesSystematic Review of Pain Severity and Opioid Craving in Chronic Pain and Opioid Use Disorder
MacLean RR, Spinola S, Manhapra A, Sofuoglu M. Systematic Review of Pain Severity and Opioid Craving in Chronic Pain and Opioid Use Disorder. Pain Medicine 2019, 21: e146-e163. PMID: 32034413, DOI: 10.1093/pm/pnz228.Peer-Reviewed Original ResearchConceptsLong-term opioid therapyOpioid use disorderChronic painPain severityOpioid therapyOpioid cravingUse disordersEligible studiesSystematic reviewOpioid use disorder patientsChronic pain populationsRisk of biasInclusion/exclusion criteriaPain populationObservational studyExclusion criteriaPainDisorder patientsPsycINFO databasesTherapyMean levelsDisordersSeverityStudy of individualsCraving
2018
Attentional bias in opioid users: A systematic review and meta-analysis
MacLean RR, Sofuoglu M, Brede E, Robinson C, Waters AJ. Attentional bias in opioid users: A systematic review and meta-analysis. Drug And Alcohol Dependence 2018, 191: 270-278. PMID: 30157467, DOI: 10.1016/j.drugalcdep.2018.07.012.Peer-Reviewed Original ResearchConceptsAttentional biasNeutral stimuliBehavioral treatmentRobust attentional biasAdjunctive behavioral treatmentsOpioid use disorderAttention biasOpioid cuesSalient stimuliEligible peer-reviewed studiesStimuliUse disordersOpioid usersCurrent studySystematic reviewPeer-reviewed studiesNational public health emergencyBiasComprehensive literature searchTreatment outcomesPublic health emergencyOpioid useActive responseCuesPrimary treatmentStimulants and Mood Disorders
MacLean R, Sofuoglu M. Stimulants and Mood Disorders. Current Addiction Reports 2018, 5: 323-329. DOI: 10.1007/s40429-018-0212-0.Peer-Reviewed Original ResearchStimulant use disorderMood disordersUse disordersSUD comorbidityClinical trialsComorbid substance use disorderRecent FindingsEpidemiological studiesCo-occurring mood disordersSubstance use disordersMethamphetamine use disorderMajority of trialsClinical outcomesPharmacological treatmentTreatment responseNeurobiological mechanismsDisordersMultiple studiesTrialsComorbiditiesPatientsDiagnosisMoodTreatmentPurposeToEpidemiology
2017
Tobacco and alcohol use disorders: Evaluating multimorbidity
MacLean RR, Sofuoglu M, Rosenheck R. Tobacco and alcohol use disorders: Evaluating multimorbidity. Addictive Behaviors 2017, 78: 59-66. PMID: 29127785, DOI: 10.1016/j.addbeh.2017.11.006.Peer-Reviewed Original ResearchConceptsTobacco use disorderAlcohol use disorderVeterans Health AdministrationUse disordersConcurrent alcohol use disorderMental health outpatient servicesMental health disordersCo-occurring diagnosesCo-occurring conditionsHepatic diseaseUse of substancesOutpatient servicesService usePsychiatric diagnosisTreatment approachesHealth disordersDisability pensionHealth AdministrationSocio-environmental factorsAdverse effectsDiagnosisDisordersGreater likelihoodVeteransHigh rate