2024
W68 Greater Coupling of Pain Intensity and Opioid Craving After Delaying Methadone Dose Among Veterans With Opioid Use Disorder
MacLean R, Spinola S, Pittman B, Meyerovich J, Szollosy S, Wolkowicz N, Sofuoglu M. W68 Greater Coupling of Pain Intensity and Opioid Craving After Delaying Methadone Dose Among Veterans With Opioid Use Disorder. Drug And Alcohol Dependence 2024, 260: 110686. DOI: 10.1016/j.drugalcdep.2023.110686.Peer-Reviewed Original ResearchThe relationship of pain intensity and opioid craving with delayed methadone dose: A preliminary study of individuals with opioid use disorder
MacLean R, Spinola S, Pittman B, Meyerovich J, Szollosy S, Wolkowicz N, Minnix S, Sofuoglu M. The relationship of pain intensity and opioid craving with delayed methadone dose: A preliminary study of individuals with opioid use disorder. British Journal Of Clinical Pharmacology 2024 PMID: 38439592, DOI: 10.1111/bcp.16027.Peer-Reviewed Original ResearchCold pressor testMethadone doseExperience of painOpioid cravingMethadone conditionTime course of painRelationship of pain intensityDose conditionsCourse of painAssessment of painOpioid use disorderCross-over designPain intensityPain thresholdIncreased riskPainStudy visitsPressor testDelayed dosesUse disorderCravingOpioidMethadone treatmentDoseMethadone
2022
Pre‐implementation formative evaluation of cooperative pain education and self‐management expanding treatment for real‐world access: A pragmatic pain trial
Mattocks K, LaChappelle K, Krein S, DeBar L, Martino S, Edmond S, Ankawi B, MacLean R, Higgins D, Murphy J, Cooper E, Heapy A. Pre‐implementation formative evaluation of cooperative pain education and self‐management expanding treatment for real‐world access: A pragmatic pain trial. Pain Practice 2022, 23: 338-348. PMID: 36527287, DOI: 10.1111/papr.13195.Peer-Reviewed Original ResearchConceptsCBT-CPChronic painPragmatic trialOngoing pragmatic trialVeterans Affairs sitesPrimary care cliniciansPragmatic clinical trialsVA Medical CenterEvidence-based treatmentsSystem-level factorsReal-world accessCognitive behavioral therapyPain intensityPain trialsCare cliniciansReferral pathwaysPain educationClinicians' lackClinical trialsMedical CenterSystem barriersQualitative interviewsReal-world settingIndividual qualitative interviewsClinicians' difficultyUsing Daily Ratings to Examine Treatment Dose and Response in Cognitive Behavioral Therapy for Chronic Pain: A Secondary Analysis of the Co-Operative Pain Education and Self-Management Clinical Trial
MacLean R, Buta E, Higgins D, Driscoll M, Edmond S, LaChappelle K, Ankawi B, Krein S, Piette J, Heapy A. Using Daily Ratings to Examine Treatment Dose and Response in Cognitive Behavioral Therapy for Chronic Pain: A Secondary Analysis of the Co-Operative Pain Education and Self-Management Clinical Trial. Pain Medicine 2022, 24: 846-854. PMID: 36484691, PMCID: PMC10250557, DOI: 10.1093/pm/pnac192.Peer-Reviewed Original ResearchConceptsPain intensityCognitive behavioral therapyCBT-CPChronic painTreatment responseDaily stepsSecondary analysisBehavioral therapyMeaningful changeChronic back painStrong evidence baseBack painPain educationTreatment weekClinical trialsNoninferiority trialTreatment benefitOutcome measuresWeek 4Treatment doseWeek 2Baseline weekMost respondersSurvival analysisStep count
2021
The Impact of Chronic Pain on Opioid Use Disorder Treatment Outcomes
MacLean R, Spinola S, Garcia-Vassallo G, Sofuoglu M. The Impact of Chronic Pain on Opioid Use Disorder Treatment Outcomes. Current Addiction Reports 2021, 8: 100-108. DOI: 10.1007/s40429-020-00352-6.Peer-Reviewed Original ResearchOpioid agonist treatmentChronic painOpioid use disorderOpioid Use Disorder Treatment OutcomesNonpharmacologic pain treatmentsIllicit opioid useDisorder treatment outcomesReviewChronic painOpioid usePain intensityPain treatmentAgonist treatmentOAT clinicsTreatment outcomesClinical carePainUse disordersDrug useRecent FindingsWeHigher likelihoodClinicOutcomesTreatmentMost studiesIntake
2020
Co-Operative Pain Education and Self-management (COPES) Expanding Treatment for Real-World Access (ExTRA): Pragmatic Trial Protocol
Heapy AA, Driscoll MA, Buta E, LaChappelle KM, Edmond S, Krein SL, Piette JD, Mattocks K, Murphy JL, DeBar L, MacLean RR, Ankawi B, Kawecki T, Martino S, Wagner T, Higgins DM. Co-Operative Pain Education and Self-management (COPES) Expanding Treatment for Real-World Access (ExTRA): Pragmatic Trial Protocol. Pain Medicine 2020, 21: s21-s28. PMID: 33313733, PMCID: PMC7734659, DOI: 10.1093/pm/pnaa365.Peer-Reviewed Original ResearchConceptsCBT-CPMusculoskeletal painPragmatic trialInteractive voice responseHealth care system factorsPragmatic trial protocolChronic musculoskeletal painVA Medical CenterVeterans Affairs cliniciansDepression symptom severityBudget impact analysisReal-world accessCognitive behavioral therapySecondary outcomesPain intensityPrimary outcomeChronic painPain interferenceSuperiority trialGlobal ImpressionPain educationPatient preferencesTrial protocolMedical CenterReal-world setting