2018
5 Oral Administration of Branched-Chain Amino Acids Results in Increased Seizure Threshold and Loss of Hippocampal Neurons in a Rodent Model of Mesial Temporal Lobe Epilepsy
Gruenbaum S, Dhaher R, Rapuano A, Tang A, Eid T. 5 Oral Administration of Branched-Chain Amino Acids Results in Increased Seizure Threshold and Loss of Hippocampal Neurons in a Rodent Model of Mesial Temporal Lobe Epilepsy. American Journal Of Clinical Pathology 2018, 149: s165-s166. DOI: 10.1093/ajcp/aqx149.374.Peer-Reviewed Original ResearchMesial temporal lobe epilepsyTemporal lobe epilepsyBCAA ingestionSeizure thresholdSpontaneous seizuresDays of drinkingRodent modelsLobe epilepsyDentate hilusControl ratsControl groupHilar neuron lossIncreased seizure thresholdInjection of pentylenetetrazoleSingle intraperitoneal injectionRight dentate gyrusRelevant rodent modelsGlutamine synthetase inhibitor methionine sulfoximineBranched-chain amino acid leucineBCAA groupInduced seizuresOral supplementationNeuron lossEpileptic ratsDentate gyrus
2017
2092
Gruenbaum S, Dhaher R, Rapuano A, Eid T. 2092. Journal Of Clinical And Translational Science 2017, 1: 56-56. PMCID: PMC6798929, DOI: 10.1017/cts.2017.200.Peer-Reviewed Original ResearchTemporal lobe epilepsyDays of drinkingDentate hilusBCAA groupNeuronal viabilityControl groupHilar neuron lossHilar neuronal lossRight dentate gyrusRelevant rodent modelsRole of BCAABCAA ingestionNeuronal lossSpontaneous seizuresLobe epilepsyNeuron lossSeizure activityChronic ingestionDentate gyrusInfusion siteHilar regionRodent modelsMethionine sulfoximineNeurochemical modulationRats