2024
Veteran's Health Administration HIV Care Continuum: 2019 vs 2022
Maier M, Beste L, Lowy E, Hauser R, Van Epps P, Yakovchenko V, Rogal S, Chartier M, Ross D. Veteran's Health Administration HIV Care Continuum: 2019 vs 2022. Open Forum Infectious Diseases 2024, 11: ofae382. PMID: 39086463, PMCID: PMC11288371, DOI: 10.1093/ofid/ofae382.Peer-Reviewed Original ResearchHuman immunodeficiency virusHIV care continuumViral suppressionVL resultsViral loadCare continuumFactors associated with viral suppressionTime of HIV diagnosisHuman immunodeficiency virus careRetrospective cohort analysisMultivariate logistic regressionVirologic suppressionImmunodeficiency virusHIV diagnosisVeterans Health AdministrationReceipt of careCohort analysisHealth care institutionsPWHCare qualityVHA careHealth AdministrationCare institutionsCareVHABlood type as a risk factor for pancreatic ductal adenocarcinoma.
Rahimi Larki N, Skanderson M, Tate J, Levinson R, Hauser R, Brandt C, Yang Y, Justice A, Wang L. Blood type as a risk factor for pancreatic ductal adenocarcinoma. Journal Of Clinical Oncology 2024, 42: 10559-10559. DOI: 10.1200/jco.2024.42.16_suppl.10559.Peer-Reviewed Original ResearchPancreatic ductal adenocarcinoma riskVeterans Health AdministrationRisk of pancreatic ductal adenocarcinomaNon-O blood typeNeighborhood-level socioeconomic dataIntegrated healthcare systemHigh risk of pancreatic ductal adenocarcinomaPancreatic ductal adenocarcinomaAssociated with higher riskAssociated with increased riskUnited StatesHealth AdministrationOutpatient encountersHealthcare systemBaseline ageAlcohol useIndex dateAssociation of blood typeCancer deathWhite populationSocioeconomic dataBlack patientsDiverse populationsRisk factorsBlood typeEstimating risk for pancreatic cancer among 9.4 million veterans in care.
Wang L, Rahimi Larki N, Skanderson M, Tate J, Hauser R, Brandt C, Yang Y, Justice A. Estimating risk for pancreatic cancer among 9.4 million veterans in care. Journal Of Clinical Oncology 2024, 42: 10544-10544. DOI: 10.1200/jco.2024.42.16_suppl.10544.Peer-Reviewed Original ResearchVeterans Health AdministrationGeneral populationAlcohol useIntegrated health systemElectronic health recordsTen-year riskHistory of cancerLoss to follow-upFollow-upEvaluated model discriminationMedian baseline ageCox proportional hazards modelsRisk prediction modelHealth recordsProportional hazards modelHealth systemHealth AdministrationMultivariate Cox proportional hazards modelSmoking statusCharlson Comorbidity IndexBaseline ageClinical reasoningRange of risksHazards modelFinal predictorsDevelopment and Validation of Case-Finding Algorithms to Identify Pancreatic Cancer in the Veterans Health Administration
Mezzacappa C, Larki N, Skanderson M, Park L, Brandt C, Hauser R, Justice A, Yang Y, Wang L. Development and Validation of Case-Finding Algorithms to Identify Pancreatic Cancer in the Veterans Health Administration. Digestive Diseases And Sciences 2024, 69: 1507-1513. PMID: 38453743, DOI: 10.1007/s10620-024-08324-w.Peer-Reviewed Original ResearchElectronic health recordsVeterans Health AdministrationHealth AdministrationElectronic health records data elementsElectronic health record dataDiagnosis of exocrine pancreatic cancerNational Cancer RegistryCancer RegistryHealth recordsExocrine pancreatic cancerOncology settingOutpatient encountersInpatient encountersData elementsExpert adjudicationPancreatic ductal adenocarcinomaEpidemiological studiesRandom sampleInterquartile rangeIdentification of patientsRange of patientsPancreatic cancerVeteransLate diagnosisExcellent PPVCombining Charlson comorbidity and VACS indices improves prognostic accuracy for all-cause mortality for patients with and without HIV in the Veterans Health Administration
McGinnis K, Justice A, Marconi V, Rodriguez-Barradas M, Hauser R, Oursler K, Brown S, Bryant K, Tate J, Study F. Combining Charlson comorbidity and VACS indices improves prognostic accuracy for all-cause mortality for patients with and without HIV in the Veterans Health Administration. Frontiers In Medicine 2024, 10: 1342466. PMID: 38356736, PMCID: PMC10864663, DOI: 10.3389/fmed.2023.1342466.Peer-Reviewed Original ResearchCharlson Comorbidity IndexVACS IndexHIV RNAVeterans Health AdministrationComorbid diseasesNon-AIDS conditionsCongestive heart failureAssociated with CD4Risk of mortalityMedian ageHepatitis C.Older age groupsCharlson comorbidityCD4Prognostic accuracyHeart failurePWoHComorbidity indexVA careKidney diseasePWHHIVMatched comparatorsBaseline predictorsClinical biomarkersDecreasing alloimmunization‐specific mortality in sickle cell disease in the United States: Cost‐effectiveness of a shared transfusion resource
Ito S, Pandya A, Hauser R, Krishnamurti L, Stites E, Tormey C, Krumholz H, Hendrickson J, Goshua G. Decreasing alloimmunization‐specific mortality in sickle cell disease in the United States: Cost‐effectiveness of a shared transfusion resource. American Journal Of Hematology 2024, 99: 570-576. PMID: 38279581, DOI: 10.1002/ajh.27211.Peer-Reviewed Original ResearchSickle cell diseaseDelayed hemolytic transfusion reactionQuality-adjusted life expectancyAlloimmunized patientsPatient populationRed blood cell alloimmunizationCell diseaseCost-effective interventionMedical expenditure of patientsHealth system perspectiveExpenditure of patientsIncremental cost-effectiveness ratioHemolytic transfusion reactionsUnited StatesMarkov cohort simulationCost-effectiveAverage patient populationCost-effectiveness ratioBirth cohortAnalytical time horizonAntibody historyCohort simulationTransfusionTransfusion reactionsLife expectancy
2023
Crawling toward obsolescence: The extended lifespan of amylase for pancreatitis
Kanaparthy N, Loza A, Hauser R. Crawling toward obsolescence: The extended lifespan of amylase for pancreatitis. PLOS ONE 2023, 18: e0296180. PMID: 38127992, PMCID: PMC10734915, DOI: 10.1371/journal.pone.0296180.Peer-Reviewed Original ResearchMachine learning to develop a predictive model of pressure injury in persons with spinal cord injury
Luther S, Thomason S, Sabharwal S, Finch D, McCart J, Toyinbo P, Bouayad L, Lapcevic W, Hahm B, Hauser R, Matheny M, Powell-Cope G. Machine learning to develop a predictive model of pressure injury in persons with spinal cord injury. Spinal Cord 2023, 61: 513-520. PMID: 37598263, DOI: 10.1038/s41393-023-00924-z.Peer-Reviewed Original ResearchConceptsPressure injuriesAmerican Spinal Cord Injury Association Impairment ScaleSCI/D CentersSpinal cord injury/diseaseReceiver-operating curve analysisNew pressure injuryModifiable risk factorsElectronic health record dataSCI/DSpinal cord injuryHealth record dataInjury/diseaseTwo-step logistic regressionLogistic regression modelsCohort studyRegression modelsStudy designACord injurySevere gradesRisk factorsImpairment ScaleHigh riskClinical implicationsTotal daysAnnual examPROSER: A Web-Based Peripheral Blood Smear Interpretation Support Tool Utilizing Electronic Health Record Data
Iscoe M, Loza A, Turbiville D, Campbell S, Peaper D, Balbuena-Merle R, Hauser R. PROSER: A Web-Based Peripheral Blood Smear Interpretation Support Tool Utilizing Electronic Health Record Data. American Journal Of Clinical Pathology 2023, 160: 98-105. PMID: 37026746, DOI: 10.1093/ajcp/aqad024.Peer-Reviewed Original ResearchConceptsQuality improvement studyElectronic health recordsLaboratory valuesWeb-based clinical decision support toolClinical decision support toolElectronic health record dataHealth record dataImprovement studyResident trainingBlood smear interpretationClinical outcomesMorphologic findingsAcademic hospitalCorresponding reference rangesMedication informationReference rangeMicroscopy findingsCDS toolsIntervention effectsPathology practiceSmear interpretationHealth recordsRecord dataPathologistsPatientsAssociations between ABO non‐identical platelet transfusions and patient outcomes—A multicenter retrospective analysis
Bougie D, Reese S, Birch R, Bookwalter D, Mitchell P, Roh D, Kreuziger L, Cable R, Goel R, Gottschall J, Hauser R, Hendrickson J, Hod E, Josephson C, Kahn S, Kleinman S, Mast A, Ness P, Roubinian N, Sloan S, Study‐IV‐Pediatric F. Associations between ABO non‐identical platelet transfusions and patient outcomes—A multicenter retrospective analysis. Transfusion 2023, 63: 960-972. PMID: 36994786, PMCID: PMC10175171, DOI: 10.1111/trf.17319.Peer-Reviewed Original ResearchConceptsPlatelet transfusionsHazard ratioPatient outcomesMulticenter retrospective analysisPlatelet transfusion requirementsGroup O recipientsRecipient's blood groupRisk of mortalitySpecific patient populationsBlood group ARecipient EpidemiologyTransfusion requirementsB recipientsOverall cohortProspective studyO recipientsPatient populationRetrospective analysisPlatelet dosesGroup ATransfusionABO antigensABO groupPatient exposureSignificant associationImplementation of Eye-Tracking Technology to Monitor Clinician Fatigue in Routine Clinical Care: A Feasibility Study
Kadhim B, Khairat S, Li F, Gross I, Nath B, Hauser R, Melnick E. Implementation of Eye-Tracking Technology to Monitor Clinician Fatigue in Routine Clinical Care: A Feasibility Study. ACI Open 2023, 07: e1-e7. DOI: 10.1055/s-0042-1760267.Peer-Reviewed Original ResearchRoutine clinical careFatigue scoresClinical careClinician fatigueReal-world clinical settingMixed methods feasibility studyAcademic emergency departmentSelf-reported fatigueRoutine careEmergency departmentPhysician fatigueConfounding factorsClinical settingStudy designConvenience sampleCareMedical errorsFeasibility studyCliniciansScoresPhysiological fatigueEye-tracking technologyFatigueTesting and Case Rates of Gonorrhea, Chlamydia, Syphilis, and HIV among People with Substance Use Disorders in the Veterans Health Administration
Villamagna A, Beste L, Borgerding J, Lowy E, Hauser R, Ross D, Maier M. Testing and Case Rates of Gonorrhea, Chlamydia, Syphilis, and HIV among People with Substance Use Disorders in the Veterans Health Administration. Journal Of Addiction Medicine 2023, 17: 387-393. PMID: 37579093, DOI: 10.1097/adm.0000000000001134.Peer-Reviewed Original ResearchConceptsSubstance use disordersVeterans Health AdministrationMental health diagnosesUse disordersTesting ratesCase ratesTest positivityHealth AdministrationSUD groupSingle substance use disorderVeterans Health Administration patientsMultiple substance use disordersStimulant useHealth diagnosisHIV test positivityInfections (STI) testing ratesNational retrospective analysisHigh STI ratesLow testing ratesStimulant use disorderAlcohol use disorderInfection testingNational cohortSTI ratesRetrospective analysis
2022
Assessment of the Frequency, Phenotypes, and Outcomes of Acute Liver Injury Associated with Amoxicillin/Clavulanate in 1.4 Million Patients in the Veterans Health Administration
Suzuki A, Tillmann H, Williams J, Hauser R, Frund J, Suzuki M, Prior F, Aithal G, Lucena M, Andrade R, Tong W, Hunt C. Assessment of the Frequency, Phenotypes, and Outcomes of Acute Liver Injury Associated with Amoxicillin/Clavulanate in 1.4 Million Patients in the Veterans Health Administration. Drug Safety 2022, 46: 129-143. PMID: 36547811, DOI: 10.1007/s40264-022-01255-3.Peer-Reviewed Original ResearchConceptsPre-existing liver conditionsAcute liver injuryAmoxicillin/clavulanateDrug-induced liver injuryLiver injuryLiver conditionsElectronic health record systemsHealth record systemsSignificant drug-induced liver injuryAcute Liver Injury AssociatedLiver Injury AssociatedOverall mortality riskGeneral patient populationVeterans Health AdministrationAlkaline phosphatase elevationSignificant health issueRecord systemLarge electronic health record datasetsElectronic health record datasetBilirubin elevationCholestatic injuryInpatient exposureInjury AssociatedLarge electronic health record systemHepatocellular injury2214. National Testing Assessment of Select Bacterial STIs During the COVID-19 Pandemic
Fonseca G, Maier M, Keddem S, Borgerding J, Lowy E, McFarland L, Comstock E, Van Epps P, Ohl M, Hauser R, Ross D, Beste L. 2214. National Testing Assessment of Select Bacterial STIs During the COVID-19 Pandemic. Open Forum Infectious Diseases 2022, 9: ofac492.1833. DOI: 10.1093/ofid/ofac492.1833.Peer-Reviewed Original ResearchTesting ratesSyphilis testsCOVID-19 pandemicGC testingVeterans Health Administration healthcare systemCT/GCNumber of ChlamydiaOverall testing rateElectronic health record dataAge 25 yearsHealth record dataSTI testing ratesNear-baseline levelsSelf-reported raceBackground ChlamydiaSTI diagnosisSyphilis infectionBacterial STIsSTI testingHIV statusInfection testingPatient groupRetrospective studySyphilis testingPre-pandemic levelsScreening for Latent Infections Among Users of High-Risk Immunosuppressants: A Cross-Sectional Analysis From the Veterans Health Administration Healthcare System
Schmajuk G, Montgomery A, Tarasovsky G, Li J, Hauser R, Rozenberg-Ben-Dror K, Whooley M. Screening for Latent Infections Among Users of High-Risk Immunosuppressants: A Cross-Sectional Analysis From the Veterans Health Administration Healthcare System. Journal Of Patient Safety 2022, 19: 1-7. PMID: 36395779, DOI: 10.1097/pts.0000000000001079.Peer-Reviewed Original ResearchConceptsHigher screening ratesVeterans Health AdministrationScreening ratesCross-sectional analysisHepatitis B virusHepatitis C virusLatent hepatitis B virusVeterans Affairs (VA) Corporate Data WarehouseElectronic health record-based toolsVeterans Health Administration healthcare systemNational Veterans Health AdministrationCross-sectional analysis of veteransLow-performing facilitiesGuideline-recommended screeningFacility-level factorsB/ts-DMARDsMixed-effects multivariable logistic regression modelAnalysis of veteransCorporate Data WarehouseMultivariate logistic regression modelHigher-volume facilitiesBlack/African American patientsLogistic regression modelsSynthetic disease-modifying antirheumatic drugsTargeted synthetic disease-modifying antirheumatic drugsA US-Wide Red Blood Cell Alloantibody Exchange Can Decrease Mortality and Produce Cost Savings in the Care of Alloimmunized Patients with Sickle Cell Disease
Goshua G, Hauser R, Tormey C, Pandya A, Hendrickson J. A US-Wide Red Blood Cell Alloantibody Exchange Can Decrease Mortality and Produce Cost Savings in the Care of Alloimmunized Patients with Sickle Cell Disease. Blood 2022, 140: 2147-2148. DOI: 10.1182/blood-2022-169099.Peer-Reviewed Original ResearchGonorrhea and Chlamydia Testing and Case Rates Among Women Veterans in the Veterans Health Administration
Keddem S, Maier M, Gardella C, Borgerding J, Lowy E, Chartier M, Haskell S, Hauser RG, Beste LA. Gonorrhea and Chlamydia Testing and Case Rates Among Women Veterans in the Veterans Health Administration. Journal Of General Internal Medicine 2022, 37: 706-713. PMID: 36042092, PMCID: PMC9481769, DOI: 10.1007/s11606-022-07578-2.Peer-Reviewed Original ResearchConceptsVeterans Health AdministrationChlamydia testingVHA careWomen veteransAge 25Case ratesMilitary sexual traumaHealth AdministrationInfection rateCorrelates of testingIncidence of chlamydiaRetrospective cohort studyCervical cancer screeningEvidence-based guidelinesHealth system factorsIncidence of gonorrhoeaMental health diagnosesLow testing ratesSexual traumaSystem-level interventionsHigher infection rateEffective diagnostic testCohort studyPatient characteristicsResultsAmong womenSexually Transmitted Infection Testing in the National Veterans Health Administration Patient Cohort During the Coronavirus Disease 2019 Pandemic
Beste L, Keddem S, Borgerding J, Lowy E, Gardella C, McFarland L, Comstock E, Fonseca G, Van Epps P, Ohl M, Hauser R, Ross D, Maier M. Sexually Transmitted Infection Testing in the National Veterans Health Administration Patient Cohort During the Coronavirus Disease 2019 Pandemic. Open Forum Infectious Diseases 2022, 9: ofac433. PMID: 36514443, PMCID: PMC9452156, DOI: 10.1093/ofid/ofac433.Peer-Reviewed Original ResearchChlamydia/gonorrheaVeterans Health AdministrationHIV testingInfection testingHawaiian/Pacific IslanderTesting ratesChlamydia/gonorrhea testingHuman immunodeficiency virus (HIV) testingTransmitted Infection TestingElectronic health record dataCoronavirus disease 2019 (COVID-19) pandemicHealth record dataSTI testing ratesPacific IslandersDisease 2019 pandemicSlow recoveryNear-total recoveryGonorrhoea testingPreexposure prophylaxisHIV statusRural veteransRetrospective studyPatient cohortSyphilis testingVHA systemGraphical analysis of guideline adherence to detect systemwide anomalies in HIV diagnostic testing
Hauser RG, Bhargava A, Brandt CA, Chartier M, Maier MM. Graphical analysis of guideline adherence to detect systemwide anomalies in HIV diagnostic testing. PLOS ONE 2022, 17: e0270394. PMID: 35776743, PMCID: PMC9249187, DOI: 10.1371/journal.pone.0270394.Peer-Reviewed Original ResearchConceptsHIV diagnostic testingHIV testingDiagnostic testingGuideline recommendationsClinical practiceHIV nucleic acid testHIV resistance testsElectronic medical databasesNucleic acid testDiagnostic testing guidelinesDiagnostic test resultsDelay careGuideline adherenceHIV transmissionDiagnostic workupHIV screenNational healthcare systemPractice deviationsHIV detectionTesting guidelinesComplex medical scenariosIntervention targetsMedical databasesHealthcare systemAcid testDevelopment and Implementation of a Standard Format for Clinical Laboratory Test Results
Hauser RG, Quine DB, Iscoe M, Arvisais-Anhalt S. Development and Implementation of a Standard Format for Clinical Laboratory Test Results. American Journal Of Clinical Pathology 2022, 158: 409-415. PMID: 35713605, DOI: 10.1093/ajcp/aqac067.Peer-Reviewed Original Research