Assessment of the Frequency, Phenotypes, and Outcomes of Acute Liver Injury Associated with Amoxicillin/Clavulanate in 1.4 Million Patients in the Veterans Health Administration
Suzuki A, Tillmann H, Williams J, Hauser R, Frund J, Suzuki M, Prior F, Aithal G, Lucena M, Andrade R, Tong W, Hunt C. Assessment of the Frequency, Phenotypes, and Outcomes of Acute Liver Injury Associated with Amoxicillin/Clavulanate in 1.4 Million Patients in the Veterans Health Administration. Drug Safety 2022, 46: 129-143. PMID: 36547811, DOI: 10.1007/s40264-022-01255-3.Peer-Reviewed Original ResearchConceptsPre-existing liver conditionsAcute liver injuryAmoxicillin/clavulanateDrug-induced liver injuryLiver injuryLiver conditionsElectronic health record systemsHealth record systemsSignificant drug-induced liver injuryAcute Liver Injury AssociatedLiver Injury AssociatedOverall mortality riskGeneral patient populationVeterans Health AdministrationAlkaline phosphatase elevationSignificant health issueRecord systemLarge electronic health record datasetsElectronic health record datasetBilirubin elevationCholestatic injuryInpatient exposureInjury AssociatedLarge electronic health record systemHepatocellular injury