2009
A plant 5S rRNA mimic regulates alternative splicing of transcription factor IIIA pre‐mRNAs
Hammond M, Wachter A, Breaker R. A plant 5S rRNA mimic regulates alternative splicing of transcription factor IIIA pre‐mRNAs. The FASEB Journal 2009, 23: 665.4-665.4. DOI: 10.1096/fasebj.23.1_supplement.665.4.Peer-Reviewed Original ResearchTranscription factor IIIAAlternative splicingDiverse plant lineagesRibosomal protein L5RNA polymerase IIIProtein-mRNA interactionsStructured RNA elementsPlant lineagesProtein L5Ribosomal componentsRibosomal RNAPolymerase IIIRNA elementsRRNA synthesisPrecursor mRNASplice productsStructural mimicrySplicingProtein expressionRRNARNAFunctional adaptationMRNANatural partnersLineages
2008
Gene Regulation by Riboswitches
Breaker R. Gene Regulation by Riboswitches. The FASEB Journal 2008, 22: 97.3-97.3. DOI: 10.1096/fasebj.22.1_supplement.97.3.Peer-Reviewed Original ResearchGene expressionRiboswitch classesS-adenosylmethionineUntranslated regionWidespread riboswitch classesS-adenosylhomocysteineControl gene expressionDiversity of mechanismsGene regulationAlternative splicingModern organismsBacterial mRNAsUncharacterized mechanismRiboswitchRNA elementsMolecular switchFunctional potentialAptamer structureRNADiversityExpressionMRNAEukaryotesSplicingGenesRiboswitches as new antibiotics targets
Blount K, Breaker R. Riboswitches as new antibiotics targets. The FASEB Journal 2008, 22: 264.3-264.3. DOI: 10.1096/fasebj.22.1_supplement.264.3.Peer-Reviewed Original ResearchDrug targetsAntibacterial drug discoveryNew antibiotic targetsNew cellular targetsDrug discoveryAntibiotic targetsRiboswitchGene expressionRNA structureCellular targetsDrug discoverersAntibacterial compoundsGenesLethal effectsBacteriaExpressionMetabolite analogsReceptorsTargetDiscoveryRNABindsSelective receptorsMRNARecent work