2006
Riboswitches as Genetic Control Elements
Nahvi A, Breaker R. Riboswitches as Genetic Control Elements. 2006, 89-106. DOI: 10.1007/978-0-387-47257-7_6.Peer-Reviewed Original ResearchGene control mechanismsCertain messenger RNAsGenetic control elementsGene expression systemRNA stabilityExpression platformRNA elementsExpression systemRiboswitchRNA structureLigand bindingMRNA transcriptionMessenger RNATarget metabolitesControl elementsTranscriptionControl mechanismsGenesRNABacteriaBindingExpressionTranslationMetabolitesAptamer
2000
Molecular Recognition of cAMP by an RNA Aptamer †
Koizumi M, Breaker R. Molecular Recognition of cAMP by an RNA Aptamer †. Biochemistry 2000, 39: 8983-8992. PMID: 10913311, DOI: 10.1021/bi000149n.Peer-Reviewed Original Research
1998
Mechanism for allosteric inhibition of an ATP-sensitive ribozyme
Tang J, Breaker R. Mechanism for allosteric inhibition of an ATP-sensitive ribozyme. Nucleic Acids Research 1998, 26: 4214-4221. PMID: 9722642, PMCID: PMC147823, DOI: 10.1093/nar/26.18.4214.Peer-Reviewed Original ResearchConceptsAllosteric ribozymesModular rational designFunctional modulationEffector moleculesSelf-cleaving ribozymesFunction of ribozymesSmall effector moleculesPresence of ATPAbsence of ATPAptamer domainStructural basisLigand bindingAllosteric inhibitionRibozyme domainPossible mechanismTertiary structureConformational changesRibozyme