2007
Chapter 8
Link K, Breaker R. Chapter 8. 2007, 134-152. DOI: 10.1039/9781847557988-00134.Peer-Reviewed Original Research
2002
Deoxyribozymes: new activities and new applications
Emilsson G, Breaker R. Deoxyribozymes: new activities and new applications. Cellular And Molecular Life Sciences 2002, 59: 596-607. PMID: 12022469, PMCID: PMC11337523, DOI: 10.1007/s00018-002-8452-4.Peer-Reviewed Original Research
1999
Deoxyribozymes: New players in the ancient game of biocatalysis
Li Y, Breaker R. Deoxyribozymes: New players in the ancient game of biocatalysis. Current Opinion In Structural Biology 1999, 9: 315-323. PMID: 10361095, DOI: 10.1016/s0959-440x(99)80042-6.Peer-Reviewed Original ResearchConceptsSubstrate recognitionGenetic informationIdeal storage systemBiological catalysisRNA counterpartsInert characterChemical reactionsDNANovel chemicalRate enhancementSubstantial untapped potentialNew playersArtificial DNAHelical structurePolynucleotide chainSurprising varietyDeoxyribozymesRecent studiesStructure formationProteinCatalysisBiocatalysisStorage systemReactionChemicalsKinetics of RNA Degradation by Specific Base Catalysis of Transesterification Involving the 2‘-Hydroxyl Group
Li Y, Breaker R. Kinetics of RNA Degradation by Specific Base Catalysis of Transesterification Involving the 2‘-Hydroxyl Group. Journal Of The American Chemical Society 1999, 121: 5364-5372. DOI: 10.1021/ja990592p.Peer-Reviewed Original ResearchSpecific base catalysisBase catalysisHydroxyl groupsRNA phosphodiesterRate enhancementMaximum rate enhancementGeneral base catalysisEnzyme mimicsAlkaline pH conditionsHydroxide ionTransfer reactionsReaction conditionsCatalysisBase-catalyzed cleavageDivalent magnesiumRNA polymersDNA/RNARNA linkageTransesterification reactionPH conditionsCleavage mechanismStrand scissionRNA transesterificationBiological systemsDominant pathway
1997
DNA enzymes
Breaker R. DNA enzymes. Nature Biotechnology 1997, 15: 427-431. PMID: 9131619, DOI: 10.1038/nbt0597-427.Peer-Reviewed Original Research
1995
Self-Incorporation of coenzymes by ribozymes
Breaker R, Joyce G. Self-Incorporation of coenzymes by ribozymes. Journal Of Molecular Evolution 1995, 40: 551-558. PMID: 7643406, DOI: 10.1007/bf00160500.Peer-Reviewed Original ResearchConceptsFunctional groupsCoenzyme analoguesAdditional functional groupsChemical functional groupsChemical moietiesTransfer reactionsCovalent attachmentRNA enzymeAbsence of proteinStandard nucleotidesCatalysisCatalytic functionRibozyme activityRNA worldRibozymeMoietyAnaloguesCoenzymeCoA-SHMoleculesReaction