Comparative Effectiveness of Pharmacologic Interventions for Pulmonary Arterial Hypertension A Systematic Review and Network Meta-Analysis
Jain S, Khera R, Girotra S, Badesch D, Wang Z, Murad MH, Blevins A, Schmidt GA, Singh S, Gerke AK. Comparative Effectiveness of Pharmacologic Interventions for Pulmonary Arterial Hypertension A Systematic Review and Network Meta-Analysis. CHEST Journal 2016, 151: 90-105. PMID: 27615023, PMCID: PMC5310124, DOI: 10.1016/j.chest.2016.08.1461.Peer-Reviewed Original ResearchMeSH KeywordsAntihypertensive AgentsComparative Effectiveness ResearchHumansHypertension, PulmonaryNetwork Meta-AnalysisConceptsPulmonary arterial hypertensionEndothelin receptor antagonistsArterial hypertensionPharmacologic interventionsFunctional statusNew York Heart Association/World Health Organization functional classWorld Health Organization functional classSystematic reviewFuture comparative-effectiveness trialDiscontinuation of therapyA Systematic ReviewComparative effectiveness trialNetwork Meta-AnalysisPatient-centered approachClinical worseningCochrane RegisterSubcutaneous prostanoidsEfficacy outcomesPlacebo groupPlacebo ratesAdverse eventsReceptor antagonistPharmacologic agentsEffectiveness trialComparative efficacy