2019
Diagnostic and prognostic utility of cardiac troponin in post-cardiac arrest care
Agusala V, Khera R, Cheeran D, Mody P, Reddy PP, Link MS. Diagnostic and prognostic utility of cardiac troponin in post-cardiac arrest care. Resuscitation 2019, 141: 69-72. PMID: 31201884, DOI: 10.1016/j.resuscitation.2019.06.004.Peer-Reviewed Original ResearchConceptsLeft ventricular systolic dysfunctionIschemic etiologyInitial cTnTPeak cTnTCardiac troponinPost-cardiac arrest settingRetrospective single-center registryPost-cardiac arrest careVentricular systolic dysfunctionSingle-center registryTroponin T testingSystolic dysfunctionCenter registryConsecutive patientsSpontaneous circulationArrest carePrognostic utilityCardiac arrestMean agePatient outcomesExpert adjudicationEtiologyCTnTDiagnostic testsT-testingTargeted temperature management for cardiac arrest
Mody P, Kulkarni N, Khera R, Link MS. Targeted temperature management for cardiac arrest. Progress In Cardiovascular Diseases 2019, 62: 272-278. PMID: 31078561, DOI: 10.1016/j.pcad.2019.05.007.Peer-Reviewed Original ResearchConceptsHospital sudden cardiac arrestSudden cardiac arrestTemperature managementCardiac arrestSurvivors of SCAInitial shockable rhythmTargeted temperature managementInitial clinical trialsNon-shockable rhythmCore body temperatureTherapeutic hypothermiaDuration of coolingNeurological functionShockable rhythmPatient populationClinical trialsCurrent guidelinesNeurological damageCurrent evidenceSevere hypoxiaSurvivorsBody temperatureReview articleArrestSignificant improvementPulselessness After Initiation of Cardiopulmonary Resuscitation for Bradycardia in Hospitalized Children
Khera R, Tang Y, Girotra S, Nadkarni VM, Link MS, Raymond TT, Guerguerian AM, Berg RA, Chan PS, Investigators F. Pulselessness After Initiation of Cardiopulmonary Resuscitation for Bradycardia in Hospitalized Children. Circulation 2019, 140: 370-378. PMID: 31006260, PMCID: PMC6663562, DOI: 10.1161/circulationaha.118.039048.Peer-Reviewed Original ResearchConceptsPulseless cardiac arrestHospital cardiac arrestCardiac arrestCardiopulmonary resuscitationPediatric patientsHospitalized childrenPoor perfusionHospital dischargeMinutes of CPRPredictors of survivalRate of progressionMultilevel Poisson regression modelsYears of ageRate of survivalPoisson regression modelsRisk-adjusted ratesGuidelines-ResuscitationPostresuscitation careResuscitation attemptsBradycardiaHigh riskPulseless arrestChest compressionsPulselessnessCPR eventsAdministrative Billing Codes for Identifying Patients With Cardiac Arrest
DeZorzi C, Boyle B, Qazi A, Luthra K, Khera R, Chan PS, Girotra S. Administrative Billing Codes for Identifying Patients With Cardiac Arrest. Journal Of The American College Of Cardiology 2019, 73: 1598-1600. PMID: 30922482, PMCID: PMC6625314, DOI: 10.1016/j.jacc.2019.01.030.Peer-Reviewed Original ResearchAssociation Between Hospital Recognition for Resuscitation Guideline Adherence and Rates of Survival for In-Hospital Cardiac Arrest
Khera R, Tang Y, Link MS, Krumholz HM, Girotra S, Chan PS. Association Between Hospital Recognition for Resuscitation Guideline Adherence and Rates of Survival for In-Hospital Cardiac Arrest. Circulation Cardiovascular Quality And Outcomes 2019, 12: e005429. PMID: 30871337, PMCID: PMC6592630, DOI: 10.1161/circoutcomes.118.005429.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAwards and PrizesFemaleGuideline AdherenceHeart ArrestHospital MortalityHospitalsHumansInpatientsMaleMiddle AgedOutcome and Process Assessment, Health CarePatient DischargePractice Guidelines as TopicPractice Patterns, Physicians'Quality Indicators, Health CareRegistriesResuscitationTime FactorsTime-to-TreatmentTreatment OutcomeUnited StatesYoung AdultConceptsHospital cardiac arrestCardiac arrestRate of survivalSpontaneous circulationIn-Hospital Cardiac ArrestGuidelines-Resuscitation registryCardiac arrest survivalEndotracheal tube placementHigh rateHospital performanceBest tertileGuidelines-ResuscitationNational GetGuideline adherenceOverall survivalBackground HospitalTube placementNational registryChest compressionsResuscitation qualityHospitalHospital recognitionAward statusSurvivalWeak association
2017
Administrative Codes for Capturing In-Hospital Cardiac Arrest
Khera R, Spertus JA, Starks MA, Tang Y, Bradley SM, Girotra S, Chan PS. Administrative Codes for Capturing In-Hospital Cardiac Arrest. JAMA Cardiology 2017, 2: 1275-1277. PMID: 28877294, PMCID: PMC5736791, DOI: 10.1001/jamacardio.2017.2904.Peer-Reviewed Original ResearchAdministrative Claims, HealthcareAgedAged, 80 and overCardiopulmonary ResuscitationDatabases, FactualElectric CountershockFemaleHeart ArrestHospitalizationHumansInformation Storage and RetrievalInternational Classification of DiseasesMaleMedicareRegistriesTachycardia, VentricularUnited StatesVentricular FibrillationVentricular Flutter
2016
Hospital Variation in Time to Epinephrine for Nonshockable In-Hospital Cardiac Arrest
Khera R, Chan PS, Donnino M, Girotra S. Hospital Variation in Time to Epinephrine for Nonshockable In-Hospital Cardiac Arrest. Circulation 2016, 134: 2105-2114. PMID: 27908910, PMCID: PMC5173427, DOI: 10.1161/circulationaha.116.025459.Peer-Reviewed Original ResearchConceptsHospital cardiac arrestEpinephrine administrationCardiac arrestFunctional recoveryHospital variationNonshockable rhythmsHospital ratesSurvival rateRisk-standardized survival ratesIn-Hospital Cardiac ArrestHospital-level outcomesRisk-standardized ratesDose of epinephrineMedian survival rateOdds of delayHigh rateGuidelines-ResuscitationAdult patientsOverall survivalWorse survivalSimilar patientsLowest quartileImproved outcomesHospitalPatientsVariation in Hospital Use and Outcomes Associated With Pulmonary Artery Catheterization in Heart Failure in the United States
Khera R, Pandey A, Kumar N, Singh R, Bano S, Golwala H, Kumbhani DJ, Girotra S, Fonarow GC. Variation in Hospital Use and Outcomes Associated With Pulmonary Artery Catheterization in Heart Failure in the United States. Circulation Heart Failure 2016, 9: e003226. PMID: 27780836, PMCID: PMC5123800, DOI: 10.1161/circheartfailure.116.003226.Peer-Reviewed Original ResearchMeSH KeywordsAgedArrhythmias, CardiacCase-Control StudiesCatheterization, Swan-GanzCerebrovascular DisordersCoronary Artery DiseaseDatabases, FactualDisease ManagementFemaleHeart ArrestHeart FailureHospital MortalityHospitalsHumansLength of StayLogistic ModelsMaleMiddle AgedMyocardial InfarctionOdds RatioPractice Patterns, Physicians'Propensity ScoreShock, CardiogenicUnited StatesConceptsPA catheterizationHeart failureCatheter useHospital useDiseases-Ninth Revision codesPropensity-matched analysisPulmonary artery catheterPulmonary artery catheterizationHospital-level variabilityHF hospitalizationHospital mortalityArtery catheterArtery catheterizationNumber of hospitalsPA catheterRevision codesPatient outcomesAcademic hospitalExcess mortalityOdds ratioOutcomes AssociatedCatheterizationInternational ClassificationHospitalMortality