2017
Role of Hospital Volumes in Identifying Low-Performing and High-Performing Aortic and Mitral Valve Surgical Centers in the United States
Khera R, Pandey A, Koshy T, Ayers C, Nallamothu BK, Das SR, Drazner MH, Jessen ME, Kirtane AJ, Gardner TJ, de Lemos JA, Bhatt DL, Kumbhani DJ. Role of Hospital Volumes in Identifying Low-Performing and High-Performing Aortic and Mitral Valve Surgical Centers in the United States. JAMA Cardiology 2017, 2: 1322-1331. PMID: 29117319, PMCID: PMC5815001, DOI: 10.1001/jamacardio.2017.4003.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAortic ValveBayes TheoremCoronary Artery BypassDatabases, FactualFemaleHeart Valve Prosthesis ImplantationHospital Bed CapacityHospital MortalityHospitals, High-VolumeHospitals, Low-VolumeHospitals, TeachingHumansMaleMiddle AgedMitral ValveMitral Valve AnnuloplastyQuality of Health CareUnited StatesConceptsSurgical aortic valve replacementRisk-standardized mortality ratesMV replacementHospital procedure volumeMV repair proceduresHospital volumeSurgical proceduresProcedure volumeMitral Valve Surgical ProceduresHospital risk-standardized mortality ratesHigh-volume tertilesHospital surgical volumeMV surgical proceduresRisk-standardized outcomesAortic valve replacementCoronary artery bypassLow-volume hospitalsGood surgical outcomeMedian annual volumeRisk-adjusted outcomesLowest volume tertileHospital performanceRepair proceduresSAVR proceduresArtery bypass
2016
Chemoprevention of colorectal cancer in individuals with previous colorectal neoplasia: systematic review and network meta-analysis
Dulai PS, Singh S, Marquez E, Khera R, Prokop LJ, Limburg PJ, Gupta S, Murad MH. Chemoprevention of colorectal cancer in individuals with previous colorectal neoplasia: systematic review and network meta-analysis. The BMJ 2016, 355: i6188. PMID: 27919915, PMCID: PMC5137632, DOI: 10.1136/bmj.i6188.Peer-Reviewed Original ResearchConceptsLow-dose aspirinNon-aspirin NSAIDsMetachronous neoplasiaDose aspirinColorectal neoplasiaColorectal cancerChemoprevention agentsSystematic reviewCandidate agentCandidate chemoprevention agentsMetachronous colorectal cancerHigh-dose aspirinPrimary efficacy outcomeSerious adverse eventsEfficacy of agentsQuality of evidenceWeb of ScienceEfficacy outcomesAdverse eventsFavorable riskSafety profileBenefit profileClinical trialsGRADE criteriaSafety outcomesAssociation of Pharmacological Treatments for Obesity With Weight Loss and Adverse Events: A Systematic Review and Meta-analysis
Khera R, Murad MH, Chandar AK, Dulai PS, Wang Z, Prokop LJ, Loomba R, Camilleri M, Singh S. Association of Pharmacological Treatments for Obesity With Weight Loss and Adverse Events: A Systematic Review and Meta-analysis. JAMA 2016, 315: 2424-2434. PMID: 27299618, PMCID: PMC5617638, DOI: 10.1001/jama.2016.7602.Peer-Reviewed Original ResearchConceptsAdverse eventsClinical trialsWeight lossObese adultsHigher oddsAdverse event-related treatment discontinuationSystematic reviewSignificant excess weight lossCumulative ranking (SUCRA) probabilitiesDiscontinuation of therapyExcess weight lossProportion of patientsManagement of obesityQuality of evidenceWeight loss agentsWeb of ScienceTreatment discontinuationCochrane CENTRALPharmacological treatmentMagnitude of decreaseGRADE criteriaDrug treatmentLiraglutideMAIN OUTCOMEPlacebo participants