2021
Down-regulation of GP130 signaling sensitizes bladder cancer to cisplatin by impairing Ku70 DNA repair signaling and promoting apoptosis
He S, Li G, Schätzlein AG, Humphrey PA, Weiss RM, Uchegbu IF, Martin DT. Down-regulation of GP130 signaling sensitizes bladder cancer to cisplatin by impairing Ku70 DNA repair signaling and promoting apoptosis. Cellular Signalling 2021, 81: 109931. PMID: 33529758, DOI: 10.1016/j.cellsig.2021.109931.Peer-Reviewed Original ResearchConceptsBladder cancer cellsCancer cellsHuman bladder cancer specimensCisplatin-based chemotherapyBladder cancer treatmentBladder cancer specimensChemoresistant bladder cancer cellsBreast cancer cellsCell viabilityBladder cancerCancer specimensSmall molecule inhibitorsLevels of Ku70Cancer treatmentKu70 expression
2006
A role for Akt in the rapid regulation of inflammatory and apoptotic pathways in mouse bladder
Tamarkin FJ, Kang WS, Cohen JJ, Wheeler MA, Weiss RM. A role for Akt in the rapid regulation of inflammatory and apoptotic pathways in mouse bladder. Naunyn-Schmiedeberg's Archives Of Pharmacology 2006, 373: 349-359. PMID: 16832691, DOI: 10.1007/s00210-006-0081-2.Peer-Reviewed Original ResearchConceptsApoptotic pathwayPI3KAkt phosphorylationNon-phosphorylated speciesPhosphatidylinositol-3 kinaseNF-κBPhosphorylation of AktPI3K/AktCellular signalingTranscription factorsForkhead familyPI3K inhibitorsNF-κB phosphorylationKappa BDownstream pathwaysAkt activationInhibitor kappa BPhosphorylationRapid regulationAktProtein amountNuclear factor kappa BK inhibitorsCancer cellsUrothelial cancer cells
2002
Bladder cancer detection with urinary survivin, an inhibitor of apoptosis.
Sharp JD, Hausladen DA, Maher MG, Wheeler MA, Altieri DC, Weiss RM. Bladder cancer detection with urinary survivin, an inhibitor of apoptosis. Frontiers In Bioscience-Landmark 2002, 7: e36-41. PMID: 11815300, DOI: 10.2741/sharp.Peer-Reviewed Original ResearchMeSH KeywordsApoptosisBiomarkersCarcinoma, Transitional CellChromosomal Proteins, Non-HistoneCystoscopyCytodiagnosisHumansImmunoblottingInhibitor of Apoptosis ProteinsMicrotubule-Associated ProteinsNeoplasm ProteinsNeoplasm Recurrence, LocalSensitivity and SpecificitySurvivinUrinary Bladder Neoplasms
1999
Tumor Content of the Antiapoptosis Molecule Survivin and Recurrence of Bladder Cancer
Swana H, Grossman D, Anthony J, Weiss R, Altieri D. Tumor Content of the Antiapoptosis Molecule Survivin and Recurrence of Bladder Cancer. New England Journal Of Medicine 1999, 341: 452-453. PMID: 10438269, DOI: 10.1056/nejm199908053410614.Peer-Reviewed Original ResearchAgedApoptosisBiomarkers, TumorCarcinoma, Transitional CellDisease ProgressionFemaleHumansInhibitor of Apoptosis ProteinsMaleMicrotubule-Associated ProteinsMiddle AgedNeoplasm ProteinsNeoplasm Recurrence, LocalProteinsProto-Oncogene Proteins c-bcl-2SurvivinTumor Suppressor Protein p53Urinary Bladder Neoplasms