2008
Skint1, the prototype of a newly identified immunoglobulin superfamily gene cluster, positively selects epidermal γδ T cells
Boyden LM, Lewis JM, Barbee SD, Bas A, Girardi M, Hayday AC, Tigelaar RE, Lifton RP. Skint1, the prototype of a newly identified immunoglobulin superfamily gene cluster, positively selects epidermal γδ T cells. Nature Genetics 2008, 40: 656-662. PMID: 18408721, PMCID: PMC4167720, DOI: 10.1038/ng.108.Peer-Reviewed Original Research
2005
Sustained localized expression of ligand for the activating NKG2D receptor impairs natural cytotoxicity in vivo and reduces tumor immunosurveillance
Oppenheim DE, Roberts SJ, Clarke SL, Filler R, Lewis JM, Tigelaar RE, Girardi M, Hayday AC. Sustained localized expression of ligand for the activating NKG2D receptor impairs natural cytotoxicity in vivo and reduces tumor immunosurveillance. Nature Immunology 2005, 6: 928-937. PMID: 16116470, DOI: 10.1038/ni1239.Peer-Reviewed Original ResearchMeSH Keywords9,10-Dimethyl-1,2-benzanthraceneAnimalsCarcinomaCell Line, TumorDisease SusceptibilityDown-RegulationFemaleImmunologic SurveillanceKiller Cells, NaturalLigandsMaleMembrane ProteinsMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicNK Cell Lectin-Like Receptor Subfamily KPapillomaReceptors, ImmunologicReceptors, Natural Killer CellSkin NeoplasmsTetradecanoylphorbol AcetateT-LymphocytesTumor BurdenConceptsNKG2D downregulationNK cell-mediated cytotoxicityNatural killer cellsCell-mediated cytotoxicityInnate immune activationT cell defectsNKG2D engagementNatural cytotoxicityKiller cellsImmune activationReceptor NKG2DTumor immunosurveillanceCutaneous carcinogenesisTumor surveillanceT cellsReversible defectsRAE-1Normal epitheliumLigand expressionTumor resistanceCell defectsSustained expressionNKG2DImmunosurveillanceDownregulation
2003
Subset-specific, uniform activation among Vγ6/Vδ1+ γδ T cells elicited by inflammation
Roark C, Aydintug M, Lewis J, Yin X, Lahn M, Hahn Y, Born W, Tigelaar R, O’Brien R. Subset-specific, uniform activation among Vγ6/Vδ1+ γδ T cells elicited by inflammation. Journal Of Leukocyte Biology 2003, 75: 68-75. PMID: 14525969, DOI: 10.1189/jlb.0703326.Peer-Reviewed Original ResearchConceptsGamma delta T cell subsetT cell subsetsT cell receptorCell subsetsDelta antibodyActivation/memory phenotypeInvariant T cell receptorΓδ T cellsMemory phenotypeInflammatory responseT cellsFlow cytometryCell receptorInflammationMonoclonal antibodiesAntibodiesSelect tissuesCellsTissueSubsetVδ1ThymusThe inter-relatedness and interdependence of mouse T cell receptor γδ+ and αβ+ cells
Pennington D, Silva-Santos B, Shires J, Theodoridis E, Pollitt C, Wise E, Tigelaar R, Owen M, Hayday A. The inter-relatedness and interdependence of mouse T cell receptor γδ+ and αβ+ cells. Nature Immunology 2003, 4: 991-998. PMID: 14502287, DOI: 10.1038/ni979.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell DifferentiationCyclic AMP Response Element ModulatorDNA-Binding ProteinsFlow CytometryGene Expression ProfilingGenes, T-Cell ReceptorH-Y AntigenMaleMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicReceptors, Antigen, T-Cell, alpha-betaReceptors, Antigen, T-Cell, gamma-deltaRepressor ProteinsReverse Transcriptase Polymerase Chain ReactionRNA, MessengerT-LymphocytesConceptsΑβ T cellsConventional αβ T cellsCell developmentFunctional potentialGene profilesT cell receptorT cellsMouse T-cell receptorΓδ T cell developmentT cell developmentT cell progenitorsCell receptorGene expressionCell progenitorsCell populationsImmune responseTCR specificityCellsReceptorsPotential interdependenceProgenitorsExpression
2000
Enterocyte Expression of Interleukin 7 Induces Development of γδ T Cells and Peyer's Patches
Laky K, Lefrançois L, Lingenheld E, Ishikawa H, Lewis J, Olson S, Suzuki K, Tigelaar R, Puddington L. Enterocyte Expression of Interleukin 7 Induces Development of γδ T Cells and Peyer's Patches. Journal Of Experimental Medicine 2000, 191: 1569-1580. PMID: 10790431, PMCID: PMC2213426, DOI: 10.1084/jem.191.9.1569.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarrier ProteinsDendritic CellsEnterocytesEpidermal CellsEpidermisFatty Acid-Binding Protein 7Fatty Acid-Binding ProteinsGerminal CenterInterleukin-7Intestine, SmallMiceMice, TransgenicMyelin P2 ProteinNeoplasm ProteinsNerve Tissue ProteinsPeyer's PatchesReceptors, Antigen, T-Cell, gamma-deltaRecombinant Fusion ProteinsTissue DistributionT-LymphocytesTransgenesConceptsTCR-gammadelta cellsIntraepithelial lymphocytesT cell developmentCell developmentPeyer's patchesIL-7Extrathymic T cell developmentΓδ T cellsMucosal lymphoid tissuesGammadelta intraepithelial lymphocytesIL-7 expressionT cell receptorB cell maturationIntestinal fatty acidExtrathymic developmentLymphoid tissueT cellsIntestinal mucosaEnterocyte expressionBone marrowProtein promoterIntestinal epitheliumCell maturationCell receptorMice
1995
Regulation of Transgenic Class II Major Histocompatibility Genes in Murine Langerhans Cells
Longley J, Ding T, Levin D, Lewis J, Edelson R, Tigelaar R, Flavell R. Regulation of Transgenic Class II Major Histocompatibility Genes in Murine Langerhans Cells. Journal Of Investigative Dermatology 1995, 104: 329-334. PMID: 7860996, DOI: 10.1111/1523-1747.ep12665365.Peer-Reviewed Original ResearchConceptsSplenic dendritic cellsEpidermal Langerhans cellsLangerhans cellsDendritic cellsE expressionClass II major histocompatibility complex moleculesLangerhans cells expressionMurine Langerhans cellsMajor histocompatibility complex moleculesNear-normal levelsB6 genetic backgroundHistocompatibility complex moleculesMajor histocompatibility complex class II gene expressionImmune functionClass II proteinsImmunoperoxidase stainingCell-specific regulatory sequencesClass II gene expressionTransgenic miceCell expressionImmunofluorescence cytometryIntact animalsDecrease expressionMajor histocompatibility genesHistocompatibility genes