2009
Skin immune surveillance by T cells—A new order?
Strid J, Tigelaar RE, Hayday AC. Skin immune surveillance by T cells—A new order? Seminars In Immunology 2009, 21: 110-120. PMID: 19369094, DOI: 10.1016/j.smim.2009.03.002.Peer-Reviewed Original ResearchConceptsImmune surveillanceAdaptive immune surveillanceStress-induced antigensSystemic immune cellsSkin immune surveillanceLocal lymphocytesOrgan dysfunctionDendritic cellsImmune cellsT cellsEpithelial cellsTissue integrityCellsSurveillanceBody surfaceImmunopathologyImmunoregulationDysfunctionLymphocytesInfectionAntigenImmunoprotectionStress response
2008
Skint1, the prototype of a newly identified immunoglobulin superfamily gene cluster, positively selects epidermal γδ T cells
Boyden LM, Lewis JM, Barbee SD, Bas A, Girardi M, Hayday AC, Tigelaar RE, Lifton RP. Skint1, the prototype of a newly identified immunoglobulin superfamily gene cluster, positively selects epidermal γδ T cells. Nature Genetics 2008, 40: 656-662. PMID: 18408721, PMCID: PMC4167720, DOI: 10.1038/ng.108.Peer-Reviewed Original Research
2005
Sustained localized expression of ligand for the activating NKG2D receptor impairs natural cytotoxicity in vivo and reduces tumor immunosurveillance
Oppenheim DE, Roberts SJ, Clarke SL, Filler R, Lewis JM, Tigelaar RE, Girardi M, Hayday AC. Sustained localized expression of ligand for the activating NKG2D receptor impairs natural cytotoxicity in vivo and reduces tumor immunosurveillance. Nature Immunology 2005, 6: 928-937. PMID: 16116470, DOI: 10.1038/ni1239.Peer-Reviewed Original ResearchMeSH Keywords9,10-Dimethyl-1,2-benzanthraceneAnimalsCarcinomaCell Line, TumorDisease SusceptibilityDown-RegulationFemaleImmunologic SurveillanceKiller Cells, NaturalLigandsMaleMembrane ProteinsMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicNK Cell Lectin-Like Receptor Subfamily KPapillomaReceptors, ImmunologicReceptors, Natural Killer CellSkin NeoplasmsTetradecanoylphorbol AcetateT-LymphocytesTumor BurdenConceptsNKG2D downregulationNK cell-mediated cytotoxicityNatural killer cellsCell-mediated cytotoxicityInnate immune activationT cell defectsNKG2D engagementNatural cytotoxicityKiller cellsImmune activationReceptor NKG2DTumor immunosurveillanceCutaneous carcinogenesisTumor surveillanceT cellsReversible defectsRAE-1Normal epitheliumLigand expressionTumor resistanceCell defectsSustained expressionNKG2DImmunosurveillanceDownregulationThe Integration of Conventional and Unconventional T Cells that Characterizes Cell‐Mediated Responses
Pennington D, Vermijlen D, Wise E, Clarke S, Tigelaar R, Hayday A. The Integration of Conventional and Unconventional T Cells that Characterizes Cell‐Mediated Responses. Advances In Immunology 2005, 87: 27-59. PMID: 16102571, DOI: 10.1016/s0065-2776(05)87002-6.Peer-Reviewed Original ResearchConceptsUnconventional T cellsGene expression analysisConventional T cellsExtensive gene expression analysisT cellsExpression analysisRegulatory functionsCell-mediated immune responsesCell-mediated responsesT cell activityAntigen-specific responsesCellsInflammatory diseasesImmune responseImmunopathology
2003
Subset-specific, uniform activation among Vγ6/Vδ1+ γδ T cells elicited by inflammation
Roark C, Aydintug M, Lewis J, Yin X, Lahn M, Hahn Y, Born W, Tigelaar R, O’Brien R. Subset-specific, uniform activation among Vγ6/Vδ1+ γδ T cells elicited by inflammation. Journal Of Leukocyte Biology 2003, 75: 68-75. PMID: 14525969, DOI: 10.1189/jlb.0703326.Peer-Reviewed Original ResearchConceptsGamma delta T cell subsetT cell subsetsT cell receptorCell subsetsDelta antibodyActivation/memory phenotypeInvariant T cell receptorΓδ T cellsMemory phenotypeInflammatory responseT cellsFlow cytometryCell receptorInflammationMonoclonal antibodiesAntibodiesSelect tissuesCellsTissueSubsetVδ1ThymusThe inter-relatedness and interdependence of mouse T cell receptor γδ+ and αβ+ cells
Pennington D, Silva-Santos B, Shires J, Theodoridis E, Pollitt C, Wise E, Tigelaar R, Owen M, Hayday A. The inter-relatedness and interdependence of mouse T cell receptor γδ+ and αβ+ cells. Nature Immunology 2003, 4: 991-998. PMID: 14502287, DOI: 10.1038/ni979.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell DifferentiationCyclic AMP Response Element ModulatorDNA-Binding ProteinsFlow CytometryGene Expression ProfilingGenes, T-Cell ReceptorH-Y AntigenMaleMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicReceptors, Antigen, T-Cell, alpha-betaReceptors, Antigen, T-Cell, gamma-deltaRepressor ProteinsReverse Transcriptase Polymerase Chain ReactionRNA, MessengerT-LymphocytesConceptsΑβ T cellsConventional αβ T cellsCell developmentFunctional potentialGene profilesT cell receptorT cellsMouse T-cell receptorΓδ T cell developmentT cell developmentT cell progenitorsCell receptorGene expressionCell progenitorsCell populationsImmune responseTCR specificityCellsReceptorsPotential interdependenceProgenitorsExpression
2001
Induction of human tumor‐loaded dendritic cells
Berger C, Xu A, Hanlon D, Lee C, Schechner J, Glusac E, Christensen I, Snyder E, Holloway V, Tigelaar R, Edelson R. Induction of human tumor‐loaded dendritic cells. International Journal Of Cancer 2001, 91: 438-447. PMID: 11251964, DOI: 10.1002/1097-0215(200002)9999:9999<::aid-ijc1073>3.0.co;2-r.Peer-Reviewed Original ResearchMeSH KeywordsAntigens, CDApoptosisCD36 AntigensCell DifferentiationCell DivisionCell SurvivalCells, CulturedCytokinesCytoplasmDendritic CellsDose-Response Relationship, DrugFlow CytometryHumansImmunoglobulinsImmunohistochemistryImmunophenotypingImmunotherapyLeukapheresisLeukocytesLymphocytesMajor Histocompatibility ComplexMembrane GlycoproteinsMonocytesPhagocytosisPhenotypeTime FactorsT-LymphocytesConceptsExtracorporeal photopheresisDistinctive antigensTumor-loaded dendritic cellsStandard extracorporeal photopheresisMHC class II moleculesImproved cancer immunotherapyDendritic cell differentiationAnti-cancer vaccinesMalignant T cellsClass II moleculesTransition of monocytesDC vaccinesMalignant cell apoptosisDendritic cellsImmature DCsCancer immunotherapyCD83 expressionT cellsExogenous cytokinesSignificant proliferationCell apoptosisVaccineMembrane CD36Cell differentiationCells
2000
Development of Dendritic Epidermal T Cells with a Skewed Diversity of γδTCRs in Vδ1-Deficient Mice
Hara H, Kishihara K, Matsuzaki G, Takimoto H, Tsukiyama T, Tigelaar R, Nomoto K. Development of Dendritic Epidermal T Cells with a Skewed Diversity of γδTCRs in Vδ1-Deficient Mice. The Journal Of Immunology 2000, 165: 3695-3705. PMID: 11034374, DOI: 10.4049/jimmunol.165.7.3695.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, MonoclonalCell DifferentiationClone CellsCytokinesDendritic CellsEmbryonic and Fetal DevelopmentEpidermal CellsEpidermisFemaleFibroblast Growth Factor 10Fibroblast Growth Factor 7Fibroblast Growth FactorsGene DeletionGene Rearrangement, delta-Chain T-Cell Antigen ReceptorGenes, T-Cell Receptor deltaGenetic MarkersGrowth SubstancesImmunophenotypingMaleMiceMice, Inbred C57BLMice, KnockoutProtein ConformationReceptors, Antigen, T-Cell, gamma-deltaStem CellsThymus GlandT-LymphocytesEnterocyte Expression of Interleukin 7 Induces Development of γδ T Cells and Peyer's Patches
Laky K, Lefrançois L, Lingenheld E, Ishikawa H, Lewis J, Olson S, Suzuki K, Tigelaar R, Puddington L. Enterocyte Expression of Interleukin 7 Induces Development of γδ T Cells and Peyer's Patches. Journal Of Experimental Medicine 2000, 191: 1569-1580. PMID: 10790431, PMCID: PMC2213426, DOI: 10.1084/jem.191.9.1569.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarrier ProteinsDendritic CellsEnterocytesEpidermal CellsEpidermisFatty Acid-Binding Protein 7Fatty Acid-Binding ProteinsGerminal CenterInterleukin-7Intestine, SmallMiceMice, TransgenicMyelin P2 ProteinNeoplasm ProteinsNerve Tissue ProteinsPeyer's PatchesReceptors, Antigen, T-Cell, gamma-deltaRecombinant Fusion ProteinsTissue DistributionT-LymphocytesTransgenesConceptsTCR-gammadelta cellsIntraepithelial lymphocytesT cell developmentCell developmentPeyer's patchesIL-7Extrathymic T cell developmentΓδ T cellsMucosal lymphoid tissuesGammadelta intraepithelial lymphocytesIL-7 expressionT cell receptorB cell maturationIntestinal fatty acidExtrathymic developmentLymphoid tissueT cellsIntestinal mucosaEnterocyte expressionBone marrowProtein promoterIntestinal epitheliumCell maturationCell receptorMice
1997
Intracutaneous vaccination of rabbits with the cottontail rabbit papillomavirus (CRPV) L1 gene protects against virus challenge
Sundaram P, Tigelaar R, Brandsma J. Intracutaneous vaccination of rabbits with the cottontail rabbit papillomavirus (CRPV) L1 gene protects against virus challenge. Vaccine 1997, 15: 664-671. PMID: 9178468, DOI: 10.1016/s0264-410x(96)00237-x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, ViralAntigens, ViralBiolisticsCell DivisionCHO CellsCloning, MolecularCottontail rabbit papillomavirusCricetinaeEpitopes, T-LymphocyteInjections, SubcutaneousNeutralization TestsPapillomavirus InfectionsRabbitsT-LymphocytesTumor Virus InfectionsVaccines, SyntheticViral Structural ProteinsViral VaccinesConceptsCottontail rabbit papillomavirusHigh titered antibodiesVaccination of rabbitsCellular proliferative responseMajor capsid protein L1Capsid protein L1Papillomavirus infectionTitered antibodiesDNA vaccineVirus challengeProliferative responseIntracutaneous vaccinationPapilloma formationRabbit papillomavirusVirus-like particlesL1 geneL1 DNARabbitsVaccinationAntibodies
1995
Malignant and Normal T Cells Show Random Use of T-Cell Receptor ∝ Chain Variable Regions in Patients with Cutaneous T-Cell Lymphoma
Longley J, Tyrrell L, Lu S, Farrell J, Ding T, Yan S, Sallee D, Heald P, Berger C, Tigelaar R, Edelson R. Malignant and Normal T Cells Show Random Use of T-Cell Receptor ∝ Chain Variable Regions in Patients with Cutaneous T-Cell Lymphoma. Journal Of Investigative Dermatology 1995, 105: 62-64. PMID: 7615977, DOI: 10.1111/1523-1747.ep12312571.Peer-Reviewed Original ResearchConceptsCutaneous T-cell lymphomaT-cell lymphomaT cell receptorMalignant cellsRegion usagePathogenesis of CTCLNormal peripheral blood lymphocytesV region usagePeripheral blood lymphocytesNormal T cellsTCR V regionsMature T lymphocytesBeta-chain transcriptsBeta usageChain transcriptsOligoclonal patternAlpha usePeripheral bloodLeukemic patientsPolymerase chain reactionBlood lymphocytesChronic stimulationMalignant lymphocytesT cellsT lymphocytesImmunobiology of Mouse Dendritic Epidermal T Cells: A Decade Later, Some Answers, But Still More Questions
Tigelaar R, Lewis J. Immunobiology of Mouse Dendritic Epidermal T Cells: A Decade Later, Some Answers, But Still More Questions. Journal Of Investigative Dermatology 1995, 105: s43-s49. DOI: 10.1038/jid.1995.9.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsDendritic epidermal T cellsEpidermal T cellsT cell receptorΓδ cellsT cellsMouse dendritic epidermal T-cellsMurine dendritic epidermal T cellsCutaneous immune surveillanceNormal human skinSelf antigensImmune surveillanceNormal miceActive hair growthAdult miceEpithelial sitesCutaneous physiologyReproductive tractTissue restrictionHair growthFunctional activityMiceSkinHuman skinReceptorsOverwhelming evidenceMurine epidermal V gamma 5/V delta 1-T-cell receptor+ T cells respond to B-cell lines and lipopolysaccharides.
Reardon C, Heyborne K, Tsuji M, Zavala F, Tigelaar R, O'Brien R, Born W. Murine epidermal V gamma 5/V delta 1-T-cell receptor+ T cells respond to B-cell lines and lipopolysaccharides. Journal Of Investigative Dermatology 1995, 105: 58s-61s. PMID: 7615998, DOI: 10.1111/1523-1747.ep12316074.Peer-Reviewed Original ResearchConceptsB cell linesColony-stimulating factorCytokine productionGamma deltaGamma delta T cell linesGranulocyte-macrophage colony-stimulating factorT cell clonesB-cell lymphomaAbsence of lipopolysaccharideT cell stimulationMacrophage colony-stimulating factorCell linesT cell receptorT cell linesIL-10C57BL/6 miceB lymphoma cell lineIL-6IL-8IL-2IL-4IL-5Tumor necrosisT cellsHuman B lymphoma cell lineImmunobiology of mouse dendritic epidermal T cells: a decade later, some answers, but still more questions.
Tigelaar R, Lewis J. Immunobiology of mouse dendritic epidermal T cells: a decade later, some answers, but still more questions. Journal Of Investigative Dermatology 1995, 105: 43s-49s. PMID: 7615996, DOI: 10.1111/1523-1747.ep12315280.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsDendritic epidermal T cellsEpidermal T cellsGamma delta cellsT cell receptorT cellsMouse dendritic epidermal T-cellsMurine dendritic epidermal T cellsDelta T-cell receptorCutaneous immune surveillanceDelta cellsAlpha beta cellsNormal human skinSelf antigensImmune surveillanceNormal miceActive hair growthAdult miceBeta cellsEpithelial sitesCutaneous physiologyReproductive tractTissue restrictionHair growthFunctional activityMiceSpecific Suppression of Lupus-Like Graft-Versus-Host Disease Using Extracorporeal Photochemical Attenuation of Effector Lymphocytes
Girardi M, Herreid P, Tigelaar R. Specific Suppression of Lupus-Like Graft-Versus-Host Disease Using Extracorporeal Photochemical Attenuation of Effector Lymphocytes. Journal Of Investigative Dermatology 1995, 104: 177-182. PMID: 7829872, DOI: 10.1111/1523-1747.ep12612741.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, AntinuclearAscitesAutoimmune DiseasesDisease Models, AnimalFemaleGlomerulonephritisGraft vs Host DiseaseGraft vs Host ReactionImmunotherapy, AdoptiveKidneyLupus Erythematosus, SystemicMiceMice, Inbred C3HMice, Inbred C57BLMice, Inbred DBAPUVA TherapyT-LymphocytesVaccinationConceptsSystemic lupus erythematosus-like diseaseB6D2F1 recipientsDisease initiationD2 cellsAntinuclear antibody titerLupus-like graftProgression of graftVersus Host DiseaseSystemic lupus erythematosusC3H/HeJ xDBA/2 splenocytesHost diseaseLupus erythematosusEffector lymphocytesClinical manifestationsClinical parametersHistologic evidenceAntibody titersKidney diseaseAscites formationB6D2F1 miceInterleukin-2T cellsC57BL/6 xComplex antigens
1994
Superantigenic Staphylococcal Exotoxins Induce T-Cell Proliferation in the Presence of Langerhans Cells or Class II–Bearing Keratinocytes and Stimulate Keratinocytes to Produce T-Cell–Activating Cytokines
Tokura Y, Yagi J, O'Malley J, Lewis J, Takigawa M, Edelson R, Tigelaar R. Superantigenic Staphylococcal Exotoxins Induce T-Cell Proliferation in the Presence of Langerhans Cells or Class II–Bearing Keratinocytes and Stimulate Keratinocytes to Produce T-Cell–Activating Cytokines. Journal Of Investigative Dermatology 1994, 102: 31-38. PMID: 8288908, DOI: 10.1111/1523-1747.ep12371727.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, BacterialCell DivisionCells, CulturedCytokinesEnterotoxinsEnzyme-Linked Immunosorbent AssayEpidermal CellsEpidermisExfoliatinsFemaleHistocompatibility Antigens Class IIHumansInterferon-gammaInterleukin-1KeratinocytesLangerhans CellsLymphocyte ActivationMiceMice, Inbred BALB CMice, Inbred CBASpleenStaphylococcus aureusSuperantigensThymus GlandT-LymphocytesTumor Necrosis Factor-alphaConceptsStaphylococcal enterotoxin BT cell responsesLangerhans cellsT cellsExfoliative toxinAccessory cellsEnterotoxin BTumor necrosisT-cell receptor V beta gene segmentsT cell-activating cytokinesMajor histocompatibility complex (MHC) class II moleculesSuperantigen staphylococcal enterotoxin BMajor histocompatibility complex classMurine epidermal Langerhans cellsT-cell proliferative activityEpidermal Langerhans cellsSplenic T cellsT cell proliferationMurine splenic T cellsHistocompatibility complex classClass II moleculesEnzyme-linked immunosorbentBeta gene segmentsImmunostimulatory moleculesImmunomodulatory cytokines
1993
Skin-Selective Lymphocyte Homing Mechanisms in the Pathogenesis of Leukemic Cutaneous T-Cell Lymphoma
Heald P, Yan S, Edelson R, Tigelaar R, Picker L. Skin-Selective Lymphocyte Homing Mechanisms in the Pathogenesis of Leukemic Cutaneous T-Cell Lymphoma. Journal Of Investigative Dermatology 1993, 101: 222-226. PMID: 7688404, DOI: 10.1111/1523-1747.ep12364814.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAntigens, Differentiation, T-LymphocyteAntigens, NeoplasmCell Adhesion MoleculesEpitopesE-SelectinHumansLeukemia-Lymphoma, Adult T-CellLeukocyte Common AntigensLymphoma, T-Cell, CutaneousMembrane GlycoproteinsReceptors, Antigen, T-CellReceptors, Lymphocyte HomingSkin NeoplasmsT-LymphocytesConceptsCutaneous T-cell lymphomaT-cell lymphomaCutaneous lymphocyte antigenLymphocyte antigenT cellsErythrodermic cutaneous T-cell lymphomaLeukemic cutaneous T-cell lymphomaCutaneous T-cell lymphoma patientsSkin-associated lymphoid tissueT-cell lymphoma patientsTwo-color flow cytometryCutaneous host defenseT cells trafficMemory T cellsT cell subsetsCell surface phenotypeErythrodermic patientsLymphoma patientsPatient groupInflamed skinLymphoid tissueHoming receptorMalignant cloneLymphomaMalignant cells
1992
Expression of mouse Tla region class I genes in tissue enriched for γδ cells
Eghtesady P, Brorson K, Cheroutre H, Tigelaar R, Hood L, Kronenberg M. Expression of mouse Tla region class I genes in tissue enriched for γδ cells. Immunogenetics 1992, 36: 377-388. PMID: 1388139, DOI: 10.1007/bf00218045.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, MonoclonalBase SequenceBlotting, NorthernDNA ProbesFetusGene ExpressionGenes, MHC Class IMiceMice, Inbred BALB CMice, Inbred C57BLMolecular Sequence DataMultigene FamilyPolymerase Chain ReactionReceptors, Antigen, T-Cell, gamma-deltaRepetitive Sequences, Nucleic AcidT-LymphocytesConceptsΓδ T cellsT cellsPolymerase chain reactionTla region genesClass IΓδ T lymphocytesPresentation of antigensThymus leukemia antigenMajor histocompatibility complexRegion gene productsΓδ cellsLeukemia antigenAntigen presentationT lymphocytesRegion genesFetal tissuesTL antigensMouse major histocompatibility complexMonoclonal antibodiesHistocompatibility complexPattern of expressionAntigenChain reactionRecent evidenceNorthern blot analysisT Lymphocytes Bearing Gamma-Delta Antigen Receptors in Skin
Modlin R, Lewis J, Uyemura K, Tigelaar R. T Lymphocytes Bearing Gamma-Delta Antigen Receptors in Skin. Chemical Immunology And Allergy 1992, 53: 61-74. PMID: 1534236, DOI: 10.1159/000319103.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
1991
Murine epidermal γ/δ T cells express Fcγ receptor II encoded by the FcγRα α gene
Kuziel W, Lewis J, Nixon‐Fulton J, Tigelaar R, Tucker P. Murine epidermal γ/δ T cells express Fcγ receptor II encoded by the FcγRα α gene. European Journal Of Immunology 1991, 21: 1563-1566. PMID: 1828429, DOI: 10.1002/eji.1830210635.Peer-Reviewed Original ResearchConceptsAntibody-dependent cellular cytotoxicityNatural killer cellsT cellsKiller cellsCellular cytotoxicityReceptor IITcR gamma/delta T cellsGamma/delta T cellsLectin-dependent cellular cytotoxicityShort-term bulk culturesHuman natural killer cellsMouse natural killer (NK) cellsLong-term clonesR alphaEpidermal T cellsDelta T cellsFcγ receptor IIFc gamma receptor IIFc gamma RIICD16 expressionGamma RIIBulk culturesCell populationsNorthern blot analysisBlot analysis