2007
Characterizing tumor-promoting T cells in chemically induced cutaneous carcinogenesis
Roberts SJ, Ng BY, Filler RB, Lewis J, Glusac EJ, Hayday AC, Tigelaar RE, Girardi M. Characterizing tumor-promoting T cells in chemically induced cutaneous carcinogenesis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2007, 104: 6770-6775. PMID: 17412837, PMCID: PMC1871860, DOI: 10.1073/pnas.0604982104.Peer-Reviewed Original ResearchConceptsT cell deficiencyT cellsCell deficiencyPRO cellsCell-deficient miceTumor-infiltrating lymphocytesAnti-tumor responseT cell populationsInflammation-associated carcinogenesisT cell receptorImmunotherapeutic strategiesRegulatory cellsCancer immunosurveillanceCell reconstitutionEpidemiologic linkCutaneous carcinogenesisTumor incidenceCyclooxygenase-2Activated populationCell receptorNovel populationCell populationsChemical carcinogenesisCarcinogenesisLymphocytes
2005
Sustained localized expression of ligand for the activating NKG2D receptor impairs natural cytotoxicity in vivo and reduces tumor immunosurveillance
Oppenheim DE, Roberts SJ, Clarke SL, Filler R, Lewis JM, Tigelaar RE, Girardi M, Hayday AC. Sustained localized expression of ligand for the activating NKG2D receptor impairs natural cytotoxicity in vivo and reduces tumor immunosurveillance. Nature Immunology 2005, 6: 928-937. PMID: 16116470, DOI: 10.1038/ni1239.Peer-Reviewed Original ResearchMeSH Keywords9,10-Dimethyl-1,2-benzanthraceneAnimalsCarcinomaCell Line, TumorDisease SusceptibilityDown-RegulationFemaleImmunologic SurveillanceKiller Cells, NaturalLigandsMaleMembrane ProteinsMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicNK Cell Lectin-Like Receptor Subfamily KPapillomaReceptors, ImmunologicReceptors, Natural Killer CellSkin NeoplasmsTetradecanoylphorbol AcetateT-LymphocytesTumor BurdenConceptsNKG2D downregulationNK cell-mediated cytotoxicityNatural killer cellsCell-mediated cytotoxicityInnate immune activationT cell defectsNKG2D engagementNatural cytotoxicityKiller cellsImmune activationReceptor NKG2DTumor immunosurveillanceCutaneous carcinogenesisTumor surveillanceT cellsReversible defectsRAE-1Normal epitheliumLigand expressionTumor resistanceCell defectsSustained expressionNKG2DImmunosurveillanceDownregulation
2001
Regulation of Cutaneous Malignancy by γδ T Cells
Girardi M, Oppenheim D, Steele C, Lewis J, Glusac E, Filler R, Hobby P, Sutton B, Tigelaar R, Hayday A. Regulation of Cutaneous Malignancy by γδ T Cells. Science 2001, 294: 605-609. PMID: 11567106, DOI: 10.1126/science.1063916.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsCarcinogensCell LineCytotoxicity, ImmunologicDimerizationEpidermisEpithelial CellsHistocompatibility Antigens Class IHumansImmunologic SurveillanceLigandsMembrane ProteinsMiceMice, Inbred C57BLMinor Histocompatibility AntigensMolecular Sequence DataNK Cell Lectin-Like Receptor Subfamily KProtein ConformationProtein FoldingReceptors, Antigen, T-Cell, alpha-betaReceptors, Antigen, T-Cell, gamma-deltaReceptors, ImmunologicReceptors, Natural Killer CellRecombinant Fusion ProteinsReverse Transcriptase Polymerase Chain ReactionSkin NeoplasmsT-Lymphocyte SubsetsConceptsT cellsGammadelta cellsLocal T cellsNatural killer cellsΓδ T cellsGammadelta T cellsCytolytic T cellsSkin carcinoma cellsNKG2D engagementMultiple regimensKiller cellsCutaneous malignanciesCutaneous carcinogenesisEpithelial malignanciesRAE-1Human MICAMalignancyCarcinoma cellsSkin cellsCellsNKG2DRegimensMiceEpitheliumCarcinogenesis
1995
Targetoid hemangioma associated with pregnancy and the menstrual cycle
Morganroth G, Tigelaar R, Longley B, Luck L, Leffell D. Targetoid hemangioma associated with pregnancy and the menstrual cycle. Journal Of The American Academy Of Dermatology 1995, 32: 282-284. PMID: 7829718, DOI: 10.1016/0190-9622(95)90149-3.Peer-Reviewed Case Reports and Technical Notes
1993
Skin-Selective Lymphocyte Homing Mechanisms in the Pathogenesis of Leukemic Cutaneous T-Cell Lymphoma
Heald P, Yan S, Edelson R, Tigelaar R, Picker L. Skin-Selective Lymphocyte Homing Mechanisms in the Pathogenesis of Leukemic Cutaneous T-Cell Lymphoma. Journal Of Investigative Dermatology 1993, 101: 222-226. PMID: 7688404, DOI: 10.1111/1523-1747.ep12364814.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAntigens, Differentiation, T-LymphocyteAntigens, NeoplasmCell Adhesion MoleculesEpitopesE-SelectinHumansLeukemia-Lymphoma, Adult T-CellLeukocyte Common AntigensLymphoma, T-Cell, CutaneousMembrane GlycoproteinsReceptors, Antigen, T-CellReceptors, Lymphocyte HomingSkin NeoplasmsT-LymphocytesConceptsCutaneous T-cell lymphomaT-cell lymphomaCutaneous lymphocyte antigenLymphocyte antigenT cellsErythrodermic cutaneous T-cell lymphomaLeukemic cutaneous T-cell lymphomaCutaneous T-cell lymphoma patientsSkin-associated lymphoid tissueT-cell lymphoma patientsTwo-color flow cytometryCutaneous host defenseT cells trafficMemory T cellsT cell subsetsCell surface phenotypeErythrodermic patientsLymphoma patientsPatient groupInflamed skinLymphoid tissueHoming receptorMalignant cloneLymphomaMalignant cells
1984
The Intracutaneous Growth of Murine Lymphomas: Epidermal Invasion Is Characteristic of Multiple Tumor Phenotypes
Piepkorn M, Tigelaar R. The Intracutaneous Growth of Murine Lymphomas: Epidermal Invasion Is Characteristic of Multiple Tumor Phenotypes. Journal Of Investigative Dermatology 1984, 83: 281-285. PMID: 6237158, DOI: 10.1111/1523-1747.ep12340368.Peer-Reviewed Original ResearchConceptsMycosis fungoidesT cellsHelper/inducer T cellsCutaneous T-cell lymphomaT cell surface phenotypeInducer T cellsBALB/c originT-cell lymphomaMalignant T cellsLymphoid cell subsetsEosin-stained sectionsCenter of tumorT cell linesCytotoxic markersSézary syndromeCell subsetsBenign dermatosesDermal-epidermal junctionEpidermal necrosisParallel groupIntradermal injectionT lymphocytesSyngeneic miceSurface phenotypeLymphoid cells