Adhesion Molecules CD11a, CD18, and ICAM-1 on Human Epidermal Langerhans Cells Serve a Functional Role in the Activation of Alloreactive T Cells
Simon J, Cruz P, Tigelaar R, Sontheimer R, Bergstresser P. Adhesion Molecules CD11a, CD18, and ICAM-1 on Human Epidermal Langerhans Cells Serve a Functional Role in the Activation of Alloreactive T Cells. Journal Of Investigative Dermatology 1991, 96: 148-151. PMID: 1670950, DOI: 10.1111/1523-1747.ep12515946.Peer-Reviewed Original ResearchConceptsPeripheral blood mononuclear leukocytesAdhesion molecules CD11aAlloreactive T cellsAntigen-presenting cellsLangerhans cellsT cellsICAM-1T cell activationAdhesion moleculesAccessory signalsAllogeneic peripheral blood mononuclear leukocytesHuman epidermal Langerhans cellsBlood mononuclear leukocytesEpidermal Langerhans cellsEpidermal cellsAdhesion molecule expressionTwo-color immunofluorescenceDependent T-cell activationRelevant adhesion moleculesEfficient T cell activationAllostimulatory capacityHuman epidermal cellsLC stimulationMolecule expressionMononuclear leukocytes