2023
Therapy for Chikungunya Arthritis: A Study of 133 Brazilian Patients.
Amaral J, Bingham C, Taylor P, Vilá L, Weinblatt M, Schoen R. Therapy for Chikungunya Arthritis: A Study of 133 Brazilian Patients. American Journal Of Tropical Medicine And Hygiene 2023, 109: 542-547. PMID: 37549898, PMCID: PMC10484246, DOI: 10.4269/ajtmh.23-0205.Peer-Reviewed Original ResearchConceptsChikungunya arthritisWeeks of treatmentSwollen joint countTender joint countJoint countDAS28-erythrocyte sedimentation rateAge of patientsTreated with methotrexateDisease Activity ScoreGroup of patientsMedical record reviewAcute chikungunyaPain scoresClinical improvementBrazilian patientsAssess painClinical criteriaBaseline visitActivity scoreMaintained 5 monthsPainPatientsRecord reviewSelf-limitingRheumatology practice
2022
Pathogenesis of chronic chikungunya arthritis: Resemblances and links with rheumatoid arthritis
Amaral J, Bingham C, Taylor P, Vilá L, Weinblatt M, Schoen R. Pathogenesis of chronic chikungunya arthritis: Resemblances and links with rheumatoid arthritis. Travel Medicine And Infectious Disease 2022, 52: 102534. PMID: 36549417, DOI: 10.1016/j.tmaid.2022.102534.Peer-Reviewed Original ResearchConceptsChronic chikungunya arthritisMesenchymal stem cellsJoint painChikungunya virusReactivation of dormant virusesMorphologically similar to fibroblastsChikungunya feverEpigenetic changesChronic joint painAcute febrile illnessChikungunya virus infectionSimilar to fibroblastsMaculopapular rashChikungunya arthritisDormant virusesFebrile illnessLatent infectionMultipotent cellsStem cellsHeterogeneous groupRheumatoid arthritisPathogenic hypothesisGroup of multipotent cellsPainPatientsChikungunya Arthritis
Amaral J, Pal T, Schoen R. Chikungunya Arthritis. Rare Diseases Of The Immune System 2022, 179-190. DOI: 10.1007/978-3-031-05002-2_14.Peer-Reviewed Original ResearchDisease-modifying anti-rheumatic drugsAnti-rheumatic drugsInflammatory rheumatic diseasesChikungunya arthritisChronic arthritisSupportive careBiphasic illnessRheumatic diseasesRheumatoid arthritisInflammatory processViral infectionArthritisAlphavirus infectionMillions of peopleIllnessInfectionDiseaseChikungunyaSubtropical worldArthralgiaRashPatientsFeverMethotrexateCare
2020
Lyme disease: diagnosis and treatment.
Schoen R. Lyme disease: diagnosis and treatment. Current Opinion In Rheumatology 2020, 32: 247-254. PMID: 32141956, DOI: 10.1097/bor.0000000000000698.Peer-Reviewed Original ResearchConceptsClinical manifestationsLyme arthritisAdjunctive laboratory testsAcute systemic illnessLyme diseaseDiagnosis of Lyme diseaseTreatment of Lyme diseaseOligo-arthritisUntreated patientsClinical featuresAntibiotic treatmentSystemic illnessRheumatic diseasesInflammatory arthritisTreatment approachesRheumatoid arthritisDiagnostic testsPatientsArthritisDiseaseManifestationsTreatmentVector-borne infectionsLaboratory testsLymeChallenges in the Diagnosis and Treatment of Lyme Disease
Schoen R. Challenges in the Diagnosis and Treatment of Lyme Disease. Current Rheumatology Reports 2020, 22: 3. PMID: 31912251, DOI: 10.1007/s11926-019-0857-2.Peer-Reviewed Original ResearchConceptsTreatment of Lyme diseaseClinical featuresCourse of oral antibiotic therapyOral antibiotic therapyLate-stage manifestationLate-stage diseaseLyme diseaseAntibiotic therapyCausative organismTreatment strategiesClinical expressionLyme arthritisImpact of Lyme diseaseDiagnosisDiseasePatientsTreatmentVector-borne illnessStrains of Borrelia burgdorferiLymeWell-characterizedMorbidityTherapyFindingsIt
2005
A comparison of two treatment regimens of ceftriaxone in late Lyme disease
Dattwyler R, Wormser G, Rush T, Finkel M, Schoen R, Grunwaldt E, Franklin M, Hilton E, Bryant G, Agger W, Maladorno D. A comparison of two treatment regimens of ceftriaxone in late Lyme disease. Wiener Klinische Wochenschrift 2005, 117: 393-397. PMID: 16053194, DOI: 10.1007/s00508-005-0361-8.Peer-Reviewed Original ResearchConceptsLate Lyme diseaseDays of therapyLyme diseaseSerologic criteriaClinical cure rateMulti-center studyEvaluable patientsOpen labelAdverse eventsClinical responseClinical subsetsTreatment failureTreatment regimensCure rateEntry criteriaObjective abnormalitiesSerologic resultsSerologic reactivityPatientsLast evaluationOptimal durationCeftriaxoneDiseaseTherapyBorrelia burgdorferi
1994
IDENTIFICATION OF LYME DISEASE
Schoen R. IDENTIFICATION OF LYME DISEASE. Rheumatic Disease Clinics Of North America 1994, 20: 361-369. PMID: 8016416, DOI: 10.1016/s0889-857x(21)00053-3.Peer-Reviewed Original ResearchConceptsLate Lyme diseaseLyme diseaseSerologic testingMinority of patientsEarly Lyme diseaseChronic meningitisMost patientsRheumatic diseasesEarly diseaseChronic fatigueSuccessful treatmentDisease manifestationsHigh indexDiseasePatientsB. burgdorferiMost individualsAntibioticsTreatmentIndividualsOligoarthritisMeningitisRashSeroreactivityCliniciansLyme Carditis
Evans J, Rosenfeld L, Schoen R. Lyme Carditis. NATO Science Series A: 1994, 21-24. DOI: 10.1007/978-1-4615-2415-1_4.Peer-Reviewed Original Research
1992
Failure of Multitarget Detection of Borrelia Burgdorferi—Associated DNA Sequences in Synovial Fluids of Patients with Juvenile Rheumatoid Arthritis: a Cautionary Note
Malawista S, Schoen R, Moore T, Louis S, Dodge D, White T, Persing D. Failure of Multitarget Detection of Borrelia Burgdorferi—Associated DNA Sequences in Synovial Fluids of Patients with Juvenile Rheumatoid Arthritis: a Cautionary Note. Arthritis & Rheumatism 1992, 35: 246-248. PMID: 1734914, DOI: 10.1002/art.1780350220.Peer-Reviewed Original Research
1991
Treatment of refractory chronic Lyme arthritis with arthroscopic synovectomy
Schoen R, Aversa J, Rahn D, Steere A. Treatment of refractory chronic Lyme arthritis with arthroscopic synovectomy. Arthritis & Rheumatism 1991, 34: 1056-1060. PMID: 1859481, DOI: 10.1002/art.1780340817.Peer-Reviewed Original ResearchConceptsChronic Lyme arthritisLyme arthritisArthroscopic synovectomyMild functional limitationsLong-term followupRecurrent synovitisJoint inflammationAntibiotic therapyFollowup periodFunctional limitationsPatientsArthritisFirst monthSynovectomyFollowupSynovitisInflammationSurgeryTherapyKneeDiseaseMonths
1989
Relapsing or reinfectious lyme hepatitis
Schoen R. Relapsing or reinfectious lyme hepatitis. Hepatology 1989, 9: 335-336. PMID: 2912832, DOI: 10.1002/hep.1840090229.Peer-Reviewed Original Research
1987
The clinical evolution of Lyme arthritis.
Steere A, Schoen R, Taylor E. The clinical evolution of Lyme arthritis. Annals Of Internal Medicine 1987, 107: 725-31. PMID: 3662285, DOI: 10.7326/0003-4819-107-5-725.Peer-Reviewed Original ResearchConceptsLyme arthritisClinical evolutionDisease onsetIntermittent attacksSubjective joint painErythema chronicum migransFrank arthritisChronic synovitisErosive diseaseJoint painAntibiotic therapyMusculoskeletal painJoint disabilityMean durationJoint abnormalitiesLarge jointsArthritisPatientsLyme diseaseSubsequent manifestationBrief episodesPainDiseaseEpisodesOnsetTreatment of Lyme disease
Steere A, Green J, Hutchinson G, Rahn D, Pachner A, Schoen R, Sigal L, Taylor E, Malawista S. Treatment of Lyme disease. International Journal Of Medical Microbiology 1987, 263: 352-356. PMID: 3109144, DOI: 10.1016/s0176-6724(87)80092-5.Peer-Reviewed Original ResearchConceptsPenicillin-treated patientsLyme diseaseHigh-dose intravenous penicillinAttacks of arthritisIntravenous penicillin GHalf of patientsMajor late complicationsEarly Lyme diseaseIntramuscular benzathine penicillinIntravenous penicillinLate complicationsAntibiotic therapyArthritis patientsBenzathine penicillinMotor deficitsNeurologic abnormalitiesLate diseaseLate symptomsPatientsPhenoxymethyl penicillinAntibiotic agentsComplete recoveryDiseasePenicillin GArthritis
1985
Successful Parenteral Penicillin Therapy of Established Lyme Arthritis
Steere A, Green J, Schoen R, Taylor E, Hutchinson G, Rahn D, Malawista S. Successful Parenteral Penicillin Therapy of Established Lyme Arthritis. New England Journal Of Medicine 1985, 312: 869-874. PMID: 3883177, DOI: 10.1056/nejm198504043121401.Peer-Reviewed Original ResearchConceptsLyme arthritisComplete resolutionDouble-blind placebo-controlled trialAttacks of arthritisIntravenous penicillin GParenteral penicillin therapyPlacebo-controlled trialPenicillin-treated patientsErythema chronicum migransMean followPenicillin therapyParenteral therapyParenteral penicillinIntraarticular corticosteroidsJoint fluidArthritisPatientsLyme spirocheteFurther experienceTherapyPenicillin GOptimal courseDaysCorticosteroidsPlacebo