2018
The effect of preclinical Alzheimer's disease on age-related changes in intelligence in cognitively normal older adults
Harrington K, Dang C, Lim Y, Ames D, Laws S, Pietrzak R, Rainey-Smith S, Robertson J, Rowe C, Salvado O, Villemagne V, Masters C, Maruff P, Group F. The effect of preclinical Alzheimer's disease on age-related changes in intelligence in cognitively normal older adults. Intelligence 2018, 70: 22-29. DOI: 10.1016/j.intell.2018.07.004.Peer-Reviewed Original ResearchPreclinical Alzheimer's diseaseAge-related declineAlzheimer's diseaseNormal older adultsOlder adultsRisk of progressionClinical disease progressionRapid age-related declinesEarly Alzheimer's diseaseNormal age-related declineAge-related changesEffect of ageAβ groupProspective studyAβ statusDisease progressionSerial assessmentAbnormal amyloidPET neuroimagingLinear regression analysisNormal agingDiseaseIntellectual functionGreater age-related declineLinear mixed models
2015
Amyloid-β, Anxiety, and Cognitive Decline in Preclinical Alzheimer Disease: A Multicenter, Prospective Cohort Study
Pietrzak RH, Lim YY, Neumeister A, Ames D, Ellis KA, Harrington K, Lautenschlager NT, Restrepo C, Martins RN, Masters CL, Villemagne VL, Rowe CC, Maruff P. Amyloid-β, Anxiety, and Cognitive Decline in Preclinical Alzheimer Disease: A Multicenter, Prospective Cohort Study. JAMA Psychiatry 2015, 72: 284-291. PMID: 25629787, DOI: 10.1001/jamapsychiatry.2014.2476.Peer-Reviewed Original ResearchConceptsPreclinical Alzheimer's diseaseSubjective memory complaintsElevated anxiety symptomsVerbal memoryExecutive functionGlobal cognitionAnxiety symptomsCognitive declineCognitive changesMemory complaintsAβ statusDepressive symptomsLow anxiety groupComprehensive neuropsychological evaluationHigh anxiety groupRole of anxietyFlorbetapir F 18Visual memoryCognitive domainsVisuospatial abilitiesMild cognitive impairmentNeuropsychological evaluationCognitive functionProspective cohort studyMore rapid decline
2014
O3‐07‐01: AMYLOID β‐RELATED COGNITIVE DECLINE IN PRECLINICAL ALZHEIMER'S DISEASE IS MODERATED BY APOE AND BDNF POLYMORPHISMS
Lim Y, Lim Y, Villemagne V, Laws S, Pietrzak R, Snyder P, Ames D, Ellis K, Harrington K, Rembach A, Martins R, Rowe C, Masters C, Maruff P. O3‐07‐01: AMYLOID β‐RELATED COGNITIVE DECLINE IN PRECLINICAL ALZHEIMER'S DISEASE IS MODERATED BY APOE AND BDNF POLYMORPHISMS. Alzheimer's & Dementia 2014, 10: p221-p221. DOI: 10.1016/j.jalz.2014.04.305.Peer-Reviewed Original Research