1987
Evaluation of circulating malignant cells provides prognostic information in cutaneous T cell lymphoma.
Schechter G, Sausville E, Fischmann A, Soehnlen F, Eddy J, Matthews M, Gazdar A, Guccion J, Munson D, Makuch R. Evaluation of circulating malignant cells provides prognostic information in cutaneous T cell lymphoma. Blood 1987, 69: 841-9. PMID: 3493044, DOI: 10.1182/blood.v69.3.841.bloodjournal693841.Peer-Reviewed Original ResearchConceptsCutaneous T-cell lymphomaT-cell lymphomaBlood involvementLymphocyte morphologyRisk factorsCell lymphomaCTCL cellsIndependent risk factorExtent of diseasePretreatment risk factorsPeripheral blood lymphocyte morphologyUntreated patientsVisceral diseaseWorse survivalLymph nodesInitial diagnosisT stageAggressive featuresSkin stageCutaneous tumorsSkin plaquesPrognostic informationPatientsMalignant cellsMultivariate analysisCytologic transformation in cutaneous T cell lymphoma: a clinicopathologic entity associated with poor prognosis.
Dmitrovsky E, Matthews M, Bunn P, Schechter G, Makuch R, Winkler C, Eddy J, Sausville E, Ihde D. Cytologic transformation in cutaneous T cell lymphoma: a clinicopathologic entity associated with poor prognosis. Journal Of Clinical Oncology 1987, 5: 208-15. PMID: 3492594, DOI: 10.1200/jco.1987.5.2.208.Peer-Reviewed Original ResearchConceptsCutaneous T-cell lymphomaT-cell lymphomaCytologic transformationCell lymphomaClinical courseClinicopathologic entityCutaneous T-cell lymphoma patientsTumor cell DNA contentT-cell lymphoma patientsAggressive clinical courseDistinct clinicopathologic entityCell lymphoma patientsPeripheral blood smearMalignant T cellsLarge cell lymphomaConvoluted lymphocytesMedian survivalVisceral sitesLymph nodesOccasional patientMedian timeLymphoma patientsPoor prognosisCell DNA contentT cells
1985
Histologic assessment of lymph nodes in mycosis fungoides/sézary syndrome (cutaneous T-cell lymphoma): Clinical correlations and prognostic import of a new classification system
Sausville E, Worsham G, Matthews M, Makuch R, Fischmann A, Schechter G, Gazdar A, Bunn P. Histologic assessment of lymph nodes in mycosis fungoides/sézary syndrome (cutaneous T-cell lymphoma): Clinical correlations and prognostic import of a new classification system. Human Pathology 1985, 16: 1098-1109. PMID: 3876976, DOI: 10.1016/s0046-8177(85)80177-5.Peer-Reviewed Original ResearchMeSH KeywordsHumansLymph NodesLymphocytesLymphomaMycosis FungoidesPrognosisSezary SyndromeSkin NeoplasmsT-LymphocytesConceptsCutaneous T-cell lymphomaLymph node biopsy specimensFive-year survivalLymph node architectureLymph nodesAtypical cellsHistopathologic featuresBiopsy specimensMycosis fungoides/Sézary syndromeLymph node biopsyAtypical lymphoid cellsT-cell lymphomaExtent of skinT-cell regionsLN subgroupAtypical lymphocytesNode biopsySézary syndromeVisceral involvementMycosis fungoidesInitial diagnosisParacortical zonePrognostic valueLN classHistopathologic classification
1979
EFFECTS OF THYMOSIN IN VITRO IN CANCER PATIENTS AND CORRELATION WITH CLINICAL COURSE AFTER THYMOSIN IMMUNOTHERAPY
Chretien P, Lipson S, Makuch R, Kenady D, Cohen M. EFFECTS OF THYMOSIN IN VITRO IN CANCER PATIENTS AND CORRELATION WITH CLINICAL COURSE AFTER THYMOSIN IMMUNOTHERAPY. Annals Of The New York Academy Of Sciences 1979, 332: 135-147. PMID: 316979, DOI: 10.1111/j.1749-6632.1979.tb47107.x.Peer-Reviewed Original ResearchSerum glycoproteins in head and neck squamous carcinoma Correlations with tumor extent, clinical tumor stage, and T-cell levels during chemotherapy
Wolf G, Chretien P, Elias E, Makuch R, Baskies A, Spiegel H, Weiss J. Serum glycoproteins in head and neck squamous carcinoma Correlations with tumor extent, clinical tumor stage, and T-cell levels during chemotherapy. The American Journal Of Surgery 1979, 138: 489-500. PMID: 90464, DOI: 10.1016/0002-9610(79)90407-0.Peer-Reviewed Original ResearchConceptsΑ1-acid glycoprotein levelsT cell levelsTumor stageAcute phase proteinsUntreated patientsSerum levelsTumor extentCellular immunityImmune reactivitySquamous carcinomaPhase proteinsGlycoprotein levelsSpecific acute phase proteinsCompletion of chemotherapyClinical tumor stageChronic cigarette smokersΑ1-antitrypsin levelsΑ1-antitrypsinCellular immune parametersNeck squamous carcinomaPreoperative chemotherapyRecurrent carcinomaAlbumin levelsControl patientsRegional metastasesThymosin immunotherapy in patients with small cell carcinoma of the lung. Correlation of in vitro studies with clinical course
Lipson S, Chretien P, Makuch R, Kenady D, Cohen M. Thymosin immunotherapy in patients with small cell carcinoma of the lung. Correlation of in vitro studies with clinical course. Cancer 1979, 43: 863-870. PMID: 218717, DOI: 10.1002/1097-0142(197903)43:3<863::aid-cncr2820430313>3.0.co;2-5.Peer-Reviewed Original ResearchConceptsTotal T cellsPretreatment CEA levelsT cellsCEA levelsClinical courseCellular immunityTumor responsePretreatment levelsCarcinoembryonic antigenAdministration of thymosinIntensive chemotherapy programsPeripheral blood levelsSmall cell carcinomaDuration of responseOverall tumor responseThymus-dependent lymphocytesLarger patient populationType of treatmentP groupMechanism of actionComplete remissionT60 groupChemotherapy programBronchogenic carcinomaImmune defects
1978
Thymosin in cancer patients: in vitro effects and correlations with clinical response to thymosin immunotherapy.
Chretien P, Lipson S, Makuch R, Kenady D, Cohen M, Minna J. Thymosin in cancer patients: in vitro effects and correlations with clinical response to thymosin immunotherapy. Journal Of The National Cancer Institute 1978, 62: 1787-90. PMID: 215307.Peer-Reviewed Original Research