2005
Control Group Bias in Randomized Atypical Antipsychotic Medication Trials for Schizophrenia
Woods SW, Gueorguieva RV, Baker CB, Makuch RW. Control Group Bias in Randomized Atypical Antipsychotic Medication Trials for Schizophrenia. JAMA Psychiatry 2005, 62: 961-970. PMID: 16143728, DOI: 10.1001/archpsyc.62.9.961.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAntipsychotic AgentsBrief Psychiatric Rating ScaleDouble-Blind MethodDrug Administration ScheduleFemaleHumansMalePlacebosPsychotic DisordersRandomized Controlled Trials as TopicResearch DesignSchizophreniaSchizophrenic PsychologySelection BiasSeverity of Illness IndexSex FactorsTreatment OutcomeConceptsBrief Psychiatric Rating ScalePlacebo-controlled trialPsychiatric Rating ScalePlacebo-controlled studyAtypical antipsychotic medicationsDose-controlled studyMedication trialsAntipsychotic medicationRating ScaleDouble-blind clinical trialNew atypical antipsychotic medicationsDose-controlled trialsTreatment completion ratesPlacebo control groupEnd point changePercentage of menDrug Administration databaseRandom effects analysisIll adultsMedication armClinical trialsNew medicationsNovel medicationsSame drugAverage age
1991
EEG coherence of prefrontal areas in normal and schizophrenic males during perceptual activation
Hoffman R, Buchsbaum M, Escobar M, Makuch R, Nuechterlein K, Guich S. EEG coherence of prefrontal areas in normal and schizophrenic males during perceptual activation. Journal Of Neuropsychiatry 1991, 3: 169-175. PMID: 1821231, DOI: 10.1176/jnp.3.2.169.Peer-Reviewed Original ResearchConceptsPrefrontal areasUnmedicated male patientsAlpha band coherenceNormal male subjectsDegraded Stimulus Continuous Performance TestMale patientsCortical areasCortical circuitsNormal controlsSchizophrenic patientsBrain areasContinuous Performance TestMale subjectsPrefrontal dysfunctionSchizophrenic malesPrefrontal cortexFormer groupMultiple studiesEEG coherencePatientsExtensive connectionsSchizophreniaAlpha powerSubjectsDysfunction