1992
Pain, hyperalgesia and activity in nociceptive C units in humans after intradermal injection of capsaicin.
LaMotte R, Lundberg L, Torebjörk H. Pain, hyperalgesia and activity in nociceptive C units in humans after intradermal injection of capsaicin. The Journal Of Physiology 1992, 448: 749-764. PMID: 1593488, PMCID: PMC1176226, DOI: 10.1113/jphysiol.1992.sp019068.Peer-Reviewed Original ResearchConceptsDuration of painMagnitude of painC-nociceptorsCapsaicin injectionMechanical hyperalgesiaIntradermal injectionTopical applicationReceptive fieldsC-mechanoheat nociceptorsEffects of capsaicinMean discharge rateCutaneous hyperalgesiaHyperalgesic areaUnchanged responsivenessBackground painAlgesic substancesPeroneal nerveNociceptor excitabilityNociceptor responsesPain thresholdMechanical stimuliNociceptor dischargeIntense painConcomitant painAwake humans
1991
Neurogenic hyperalgesia: psychophysical studies of underlying mechanisms
LaMotte R, Shain C, Simone D, Tsai E. Neurogenic hyperalgesia: psychophysical studies of underlying mechanisms. Journal Of Neurophysiology 1991, 66: 190-211. PMID: 1919666, DOI: 10.1152/jn.1991.66.1.190.Peer-Reviewed Original ResearchConceptsInjection of capsaicinMechanical hyperalgesiaNerve fibersInjection siteAlgesic substancesPrimary afferent nerve fibersArea of tendernessCapsaicin injection siteMicrograms of capsaicinNociceptive nerve fibersPeripheral neural activityArea of hyperalgesiaCutaneous nerve fibersAfferent nerve fibersMagnitude of painSingle intradermal injectionNeural activityArea of analgesiaSite of injuryLarger mean areaAnesthetized skinNeurogenic hyperalgesiaCutaneous anesthesiaIntradermal injectionPainful stimuli
1984
Time-intensity profiles of cutaneous pain in normal and hyperalgesic skin: a comparison with C-fiber nociceptor activities in monkey and human
LaMotte R, Torebjörk H, Robinson C, Thalhammer J. Time-intensity profiles of cutaneous pain in normal and hyperalgesic skin: a comparison with C-fiber nociceptor activities in monkey and human. Journal Of Neurophysiology 1984, 51: 1434-1450. PMID: 6737035, DOI: 10.1152/jn.1984.51.6.1434.Peer-Reviewed Original ResearchConceptsNociceptive afferent fibersDevelopment of hyperalgesiaConditioning stimulusPain ratingsHeat stimulationAfferent fibersHairy skinHeat-evoked dischargesCervical spinal cordMagnitude of painMild heat injurySimilar response magnitudesMean frequencyPoststimulus time histogramsNociceptor activityCutaneous painResponse latencyHyperalgesic skinSpinal cordAwake humansC-fibersAnesthetized monkeysConduction velocityPainHeat stimuli
1983
Psychophysical detection and pain ratings of incremental thermal stimuli: A comparison with nociceptor responses in humans
Robinson C, Torebjörk H, LaMotte R. Psychophysical detection and pain ratings of incremental thermal stimuli: A comparison with nociceptor responses in humans. Brain Research 1983, 274: 87-106. PMID: 6616259, DOI: 10.1016/0006-8993(83)90523-1.Peer-Reviewed Original ResearchConceptsMagnitude of painThermal stimuliContact thermal stimulatorMost nociceptorsNociceptive afferentsPeroneal nerveNociceptor responsesPain magnitudePain ratingsPain sensitivityPain sensationUnmyelinated fibersPainNormal skinMild burnsPsychophysical detectionDegrees CNeural responsesNociceptorsAfferentsThermal stimulatorCapacity of humansIncrement detectionDegrees C.Detection threshold
1979
Intensive and Temporal Determinants of Thermal Pain
LaMotte R. Intensive and Temporal Determinants of Thermal Pain. 1979, 327-361. DOI: 10.1007/978-1-4613-3039-4_18.Peer-Reviewed Original ResearchMagnitude of painNociceptive afferentsNoxious stimulationNeural activityPeripheral afferent nerve fibersAfferent nerve fibersHeat-sensitive nociceptorsPain sensationPeripheral nervesConscious humansNerve fibersPainThermal painDistal endingsAfferentsNeural determinantsThreat of injuryStimulus temperatureNociceptorsStimulationInjuryReceptive fieldsSkinTemporal determinantsPsychophysical studies