2011
In vivo responses of cutaneous C-mechanosensitive neurons in mouse to punctate chemical stimuli that elicit itch and nociceptive sensations in humans
Ma C, Nie H, Gu Q, Sikand P, LaMotte RH. In vivo responses of cutaneous C-mechanosensitive neurons in mouse to punctate chemical stimuli that elicit itch and nociceptive sensations in humans. Journal Of Neurophysiology 2011, 107: 357-363. PMID: 21994268, PMCID: PMC3349700, DOI: 10.1152/jn.00801.2011.Peer-Reviewed Original ResearchConceptsNociceptive sensationsCowhage spiculesC-nociceptorsNociceptive neuronsReceptive fieldsCutaneous receptive fieldsNoxious mechanical stimuliC-fibre rangePeripheral neural mechanismsExtracellular electrophysiological recordingsAxonal conduction velocityMean discharge rateChemical itchElicit itchChemical stimuliMechanosensitive nociceptorsConduction velocityMechanosensitive neuronsHeat stimuliItchCell bodiesElectrophysiological recordingsVivo responseCapsaicinHistamine
2008
Behavioral differentiation between itch and pain in mouse
Shimada SG, LaMotte RH. Behavioral differentiation between itch and pain in mouse. Pain 2008, 139: 681-687. PMID: 18789837, PMCID: PMC2723192, DOI: 10.1016/j.pain.2008.08.002.Peer-Reviewed Original Research
1999
Attenuation of experimental pruritus and mechanically evoked dysesthesiae in an area of cutaneous allodynia
Brull S, Atanassoff P, Silverman D, Zhang J, Lamotte R. Attenuation of experimental pruritus and mechanically evoked dysesthesiae in an area of cutaneous allodynia. Somatosensory & Motor Research 1999, 16: 299-303. PMID: 10632027, DOI: 10.1080/08990229970366.Peer-Reviewed Original ResearchConceptsIntradermal injectionTactile allodyniaNociceptive primary afferent neuronsArea of allodyniaAreas of whealCapsaicin-induced allodyniaPrimary afferent neuronsCutaneous hyperalgesiaCutaneous allodyniaAfferent neuronsExperimental armControl armAllodyniaExperimental pruritusDysesthesiaeOpposite forearmVolar surfaceAlloknesisHuman volunteersItchHistamineHyperknesisHyperalgesiaInhibitory processesWhealEnhancement of experimental pruritus and mechanically evoked dysesthesiae with local anesthesia
Atanassoff P, Brull S, Zhang J, Greenquist K, Silverman D, Lamotte R. Enhancement of experimental pruritus and mechanically evoked dysesthesiae with local anesthesia. Somatosensory & Motor Research 1999, 16: 291-298. PMID: 10632026, DOI: 10.1080/08990229970357.Peer-Reviewed Original ResearchConceptsAreas of dysesthesiaDuration of itchHistamine-evoked itchPrimary afferent neuronsAbnormal sensationAfferent neuronsCutaneous areaCentral inhibitionLocal anesthesiaEnhanced painControl armIntradermal injectionLocal anestheticsExperimental pruritusPainItchVolar forearmHistamineMechanical stimulationAfferentsHuman subjectsAnestheticsSkinPresent studySensation
1991
Psychophysical Studies of the Itch Sensation and Itchy Skin (“Alloknesis”) Produced by Intracutaneous Injection of Histamine
Simone D, Alreja M, Lamotte R. Psychophysical Studies of the Itch Sensation and Itchy Skin (“Alloknesis”) Produced by Intracutaneous Injection of Histamine. Somatosensory & Motor Research 1991, 8: 271-279. PMID: 1767623, DOI: 10.3109/08990229109144750.Peer-Reviewed Original ResearchConceptsDuration of itchSubcutaneous injectionIntracutaneous injectionItchy skinArea of alloknesisSensation of itchMicrograms of histamineSkin temperatureItch sensationLocal anesthesiaAlloknesisMean latencyInjection siteMean maximum areaItchHuman volunteersHistamineVolar forearmDose-response functionInjectionNeural mechanismsSkinDoseDurationMicrograms
1987
The Magnitude and Duration of Itch Produced by Intracutaneous Injections of Histamine
Simone D, Ngeow J, Whitehouse J, Becerra-Cabal L, Putterman G, Lamotte R. The Magnitude and Duration of Itch Produced by Intracutaneous Injections of Histamine. Somatosensory & Motor Research 1987, 5: 81-92. PMID: 3423533, DOI: 10.3109/07367228709144620.Peer-Reviewed Original ResearchConceptsDuration of itchArea of flareIntracutaneous injectionDose-dependent fashionHistamine doseMicrograms of histaminePeripheral neural mechanismsDose-dependent mannerIntracutaneous histamineItch magnitudeItch sensationLow doseItchHistamineVolar forearmDoseNeurophysiological studiesLonger durationMicrogramsMultiple injectionsInjectionNeural mechanismsDurationWeeksSubjects