2006
Effects of a Chronic Compression of the Dorsal Root Ganglion on Voltage-Gated Na+ and K+ Currents in Cutaneous Afferent Neurons
Tan Z, Donnelly D, LaMotte R. Effects of a Chronic Compression of the Dorsal Root Ganglion on Voltage-Gated Na+ and K+ Currents in Cutaneous Afferent Neurons. Journal Of Neurophysiology 2006, 95: 1115-1123. PMID: 16424456, DOI: 10.1152/jn.00830.2005.Peer-Reviewed Original ResearchConceptsDorsal root gangliaCCD neuronsRoot gangliaChronic compressionTTX-sensitiveL5 dorsal root gangliaWhole-cell patch-clamp recordingsCell patch-clamp recordingsCutaneous afferent neuronsEnhanced neuronal excitabilityTTX-resistant currentSteady-state activation curvePatch-clamp recordingsCutaneous hyperalgesiaCutaneous neuronsDRG somataAfferent neuronsControl neuronsControl ratsNeuronal somataNeuronal excitabilityAdult ratsSpontaneous activityIntervertebral foraminaLower rheobase
1999
Attenuation of experimental pruritus and mechanically evoked dysesthesiae in an area of cutaneous allodynia
Brull S, Atanassoff P, Silverman D, Zhang J, Lamotte R. Attenuation of experimental pruritus and mechanically evoked dysesthesiae in an area of cutaneous allodynia. Somatosensory & Motor Research 1999, 16: 299-303. PMID: 10632027, DOI: 10.1080/08990229970366.Peer-Reviewed Original ResearchConceptsIntradermal injectionTactile allodyniaNociceptive primary afferent neuronsArea of allodyniaAreas of whealCapsaicin-induced allodyniaPrimary afferent neuronsCutaneous hyperalgesiaCutaneous allodyniaAfferent neuronsExperimental armControl armAllodyniaExperimental pruritusDysesthesiaeOpposite forearmVolar surfaceAlloknesisHuman volunteersItchHistamineHyperknesisHyperalgesiaInhibitory processesWhealEnhancement of experimental pruritus and mechanically evoked dysesthesiae with local anesthesia
Atanassoff P, Brull S, Zhang J, Greenquist K, Silverman D, Lamotte R. Enhancement of experimental pruritus and mechanically evoked dysesthesiae with local anesthesia. Somatosensory & Motor Research 1999, 16: 291-298. PMID: 10632026, DOI: 10.1080/08990229970357.Peer-Reviewed Original ResearchConceptsAreas of dysesthesiaDuration of itchHistamine-evoked itchPrimary afferent neuronsAbnormal sensationAfferent neuronsCutaneous areaCentral inhibitionLocal anesthesiaEnhanced painControl armIntradermal injectionLocal anestheticsExperimental pruritusPainItchVolar forearmHistamineMechanical stimulationAfferentsHuman subjectsAnestheticsSkinPresent studySensation
1992
Subpopulations of “nocifensor neurons” contributing to pain and allodynia, itch and alloknesis
LaMotte R. Subpopulations of “nocifensor neurons” contributing to pain and allodynia, itch and alloknesis. Journal Of Pain 1992, 1: 115-126. DOI: 10.1016/1058-9139(92)90040-j.Peer-Reviewed Original ResearchSpinothalamic tract cellsDorsal hornTract cellsNociceptive primary afferent neuronsPrimary afferent neuronsPrimary sensory neuronsCentral nervous systemNon-neuronal tissuesAfferent neuronsCutaneous mechanoreceptive afferentsPrimary afferentsConvergent inputsDifferent populationsPeripheral tissuesSensory neuronsPainCutaneous injuryNervous systemMechanoreceptive afferentsNoxious eventsProlonged enhancementNeuronsItchAllodyniaAlloknesis