2024
The Challenge of Examining Social Determinants of Health in People Living With Tourette Syndrome
Dy-Hollins M, Carr S, Essa A, Osiecki L, Lackland D, Voeks J, Mejia N, Sharma N, Budman C, Cath D, Grados M, King R, Lyon G, Rouleau G, Sandor P, Singer H, Chibnik L, Mathews C, Scharf J. The Challenge of Examining Social Determinants of Health in People Living With Tourette Syndrome. Pediatric Neurology 2024, 155: 55-61. PMID: 38608551, PMCID: PMC11132913, DOI: 10.1016/j.pediatrneurol.2024.02.008.Peer-Reviewed Original ResearchParental educational attainmentEthnic minority groupsEducational attainmentSocial determinants of healthExamining social determinants of healthNon-Hispanic White individualsDeterminants of healthDiagnosis ageNon-Hispanic whitesMinority groupsHispanic individualsWhite individualsSignificant disparitiesLogistic regressionParental educationNon-whiteComorbid conditionsNon-parametric testsEthnicityGroup differencesSymptom onsetOutcomesParticipantsResearch studiesTourette syndrome
2023
Neurodevelopmental Disorders: Stereotypical Movement Disorders and Tic Disorders
Vitulano L, Vitulano M, King R, Yazgan M, Leckman J. Neurodevelopmental Disorders: Stereotypical Movement Disorders and Tic Disorders. 2023, 1-23. DOI: 10.1007/978-3-030-42825-9_45-1.Peer-Reviewed Original ResearchStereotypic movement disorderTic disordersDevelopmental coordination disorderMovement disordersMotor disordersCoordination disorderMotor skillsNeurodevelopmental disorder groupMagnetic resonance imaging techniquesBest practice assessmentHead bangingHand flappingNeurobiological disorderDisorder groupMotor behaviorDisordersNonrhythmic movementsSuch childrenPractice assessmentUnwanted attentionChildrenImaging techniquesSkillsYearsRecurrent
2022
Mispatterning and interneuron deficit in Tourette Syndrome basal ganglia organoids
Brady M, Mariani J, Koca Y, Szekely A, King R, Bloch M, Landeros-Weisenberger A, Leckman J, Vaccarino F. Mispatterning and interneuron deficit in Tourette Syndrome basal ganglia organoids. Molecular Psychiatry 2022, 27: 5007-5019. PMID: 36447010, PMCID: PMC9949887, DOI: 10.1038/s41380-022-01880-5.Peer-Reviewed Original ResearchConceptsTourette syndromeInterneuron deficitsGABAergic interneuronsHealthy controlsNeurodevelopmental underpinningsNeuropathological deficitsBG circuitryNeuropsychiatric disordersDecreased differentiationT patientsInterneuronsAltered expressionPotential mechanismsCilia disruptionSonic hedgehogOrganoidsStem cellsTS individualsPluripotent stem cellsGli transcription factorsDeficitsOrganoid differentiationEarly stagesCholinergicPatientsPhenomenology of Tics and Sensory Urges
Leckman J, Bloch M, Sukhodolsky D, Artukoğlu B, Scahill L, King R. Phenomenology of Tics and Sensory Urges. 2022, 6-25. DOI: 10.1093/med/9780197543214.003.0002.Peer-Reviewed Original ResearchComprehensive Assessment Strategies
King R, Landeros-Weisenberger A. Comprehensive Assessment Strategies. 2022, 335-342. DOI: 10.1093/med/9780197543214.003.0020.Peer-Reviewed Original Research
2017
The PNKD gene is associated with Tourette Disorder or Tic disorder in a multiplex family
Sun N, Nasello C, Deng L, Wang N, Zhang Y, Xu Z, Song Z, Kwan K, King R, Pang Z, Xing J, Heiman G, Tischfield J. The PNKD gene is associated with Tourette Disorder or Tic disorder in a multiplex family. Molecular Psychiatry 2017, 23: 1487-1495. PMID: 28894297, PMCID: PMC5847395, DOI: 10.1038/mp.2017.179.Peer-Reviewed Original ResearchConceptsNonsense-mediated mRNA decayNonsense mutationMultiplex familiesPluripotent stem cellsTD phenotypeDeleterious sequence variantsGenetic architectureMRNA decayHouse bioinformatics pipelineDNA sequencesBioinformatics pipelineTD familyWhole-exome sequencingSequence variantsBiochemical assaysMolecular differencesWhole exomeIsoform levelsStem cellsProtein levelsTD etiologyExome sequencingPNKDHeterozygous nonsense mutationGenesGenetic and phenotypic overlap of specific obsessive-compulsive and attention-deficit/hyperactive subtypes with Tourette syndrome
Hirschtritt M, Darrow S, Illmann C, Osiecki L, Grados M, Sandor P, Dion Y, King R, Pauls D, Budman C, Cath D, Greenberg E, Lyon G, Yu D, McGrath L, McMahon W, Lee P, Delucchi K, Scharf J, Mathews C. Genetic and phenotypic overlap of specific obsessive-compulsive and attention-deficit/hyperactive subtypes with Tourette syndrome. Psychological Medicine 2017, 48: 279-293. PMID: 28651666, PMCID: PMC7909616, DOI: 10.1017/s0033291717001672.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderSymmetry/exactnessTourette syndromeLatent class analysisSymptom patternsADHD symptomsHigher psychiatric comorbidity ratesPsychiatric comorbidity ratesExploratory factor analysisHyperactive subtypeComorbidity ratesTS patientsClinical relevanceSpecific subtypesSum scoreUnique phenotypicHyperactivity disorderSymptomsPhenotypic overlapThree-class solutionTraditional diagnostic boundariesAggressive urgesSyndromeSubtypesDiagnostic boundaries896 Genetic and Phenotypic Overlap of Specific Obsessive-Compulsive Subtypes with Tourette Syndrome
Hirschtritt M, Darrow S, Illmann C, Osiecki L, Grados M, Sandor P, Dion Y, King R, Pauls D, Budman C, Cath D, Greenberg E, Lyon G, Yu D, McGrath L, McMahon W, Lee P, Delucchi K, Scharf J, Mathews C. 896 Genetic and Phenotypic Overlap of Specific Obsessive-Compulsive Subtypes with Tourette Syndrome. Biological Psychiatry 2017, 81: s361-s362. DOI: 10.1016/j.biopsych.2017.02.621.Peer-Reviewed Original Research
2015
Neurodevelopmental Disorders: Motor Disorders
Vitulano L, Vitulano M, King R, Leckman J. Neurodevelopmental Disorders: Motor Disorders. 2015, 779-790. DOI: 10.1002/9781118753378.ch47.Peer-Reviewed Original Research
2014
Tic Disorders
King R, Bloch M, Sukhodolsky D, Leckman J. Tic Disorders. 2014 DOI: 10.1176/appi.books.9781585625048.gg06.Peer-Reviewed Original Research
2013
Phenomenology of Tics and Sensory Urges: The Self Under Siege
Leckman J, Bloch M, Sukhodolsky D, Scahill L, King R. Phenomenology of Tics and Sensory Urges: The Self Under Siege. 2013, 3-25. DOI: 10.1093/med/9780199796267.003.0001.Peer-Reviewed Original ResearchAcademic outcomesComorbid behavioral problemsNovel behavioral interventionKey phenomenological featuresCognitive domainsIrrelevant informationBehavioral problemsBehavioral interventionsPhenomenology of ticsTourette syndromeLong-term outcomesPhenomenological featuresTic expressionTic disordersEnvironmental contextReduced abilitySensory urgeOutside worldRelated disordersEducational objectivesPhenomenological spectrum
2012
Genome-wide association study of Tourette's syndrome
Scharf JM, Yu D, Mathews CA, Neale BM, Stewart SE, Fagerness JA, Evans P, Gamazon E, Edlund CK, Service SK, Tikhomirov A, Osiecki L, Illmann C, Pluzhnikov A, Konkashbaev A, Davis LK, Han B, Crane J, Moorjani P, Crenshaw AT, Parkin MA, Reus VI, Lowe TL, Rangel-Lugo M, Chouinard S, Dion Y, Girard S, Cath DC, Smit JH, King RA, Fernandez TV, Leckman JF, Kidd KK, Kidd JR, Pakstis AJ, State MW, Herrera LD, Romero R, Fournier E, Sandor P, Barr CL, Phan N, Gross-Tsur V, Benarroch F, Pollak Y, Budman CL, Bruun RD, Erenberg G, Naarden AL, Lee PC, Weiss N, Kremeyer B, Berrío GB, Campbell DD, Cardona Silgado JC, Ochoa WC, Mesa Restrepo SC, Muller H, Valencia Duarte AV, Lyon GJ, Leppert M, Morgan J, Weiss R, Grados MA, Anderson K, Davarya S, Singer H, Walkup J, Jankovic J, Tischfield JA, Heiman GA, Gilbert DL, Hoekstra PJ, Robertson MM, Kurlan R, Liu C, Gibbs JR, Singleton A, Hardy J, Strengman E, Ophoff R, Wagner M, Moessner R, Mirel D, Posthuma D, Sabatti C, Eskin E, Conti D, Knowles J, Ruiz-Linares A, Rouleau G, Purcell S, Heutink P, Oostra B, McMahon W, Freimer N, Cox N, Pauls D. Genome-wide association study of Tourette's syndrome. Molecular Psychiatry 2012, 18: 721-728. PMID: 22889924, PMCID: PMC3605224, DOI: 10.1038/mp.2012.69.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAttention Deficit Disorder with HyperactivityCase-Control StudiesChromosomes, Human, Pair 9FemaleFibrillar CollagensGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeHumansInternational CooperationMaleMeta-Analysis as TopicObsessive-Compulsive DisorderPolymorphism, Single NucleotideTourette SyndromeWhite PeopleYoung AdultConceptsGenome-wide association studiesFirst genome-wide association studyAssociation studiesTop signalsFull genetic architectureAncestry-matched controlsEuropean ancestry samplesGenetic architectureGWAS dataComplex inheritanceEuropean-derived populationsSusceptibility variantsSusceptibility genesEventual identificationEuropean ancestryCosta RicaChromosome 9q32Familial recurrence rateNorth AmericaComplete understandingAmerican populationCentral ValleyNeuropsychiatric diseasesDevelopmental disordersGenes
2010
Neurobiological Substrates of Tic Disorders
Leckman J, Bloch M, Hampson M, King R. Neurobiological Substrates of Tic Disorders. 2010, 171-188. DOI: 10.1093/med/9780195398212.003.0012.Peer-Reviewed Original ResearchAssessment and Treatment of Tourette Syndrome and Other Tic Disorders
Scahill L, King R, Lombroso P, Sukhodolsky D, Leckman J. Assessment and Treatment of Tourette Syndrome and Other Tic Disorders. 2010, 516-530. DOI: 10.1093/med/9780195398212.003.0036.Chapters
2007
A Chronological Perspective on Suicide—The Last Days of Life
Orbach I, Gilboa-Schechtman E, Ofek H, Lubin G, Mark M, Bodner E, Cohen D, King R. A Chronological Perspective on Suicide—The Last Days of Life. Death Studies 2007, 31: 909-932. PMID: 17924514, DOI: 10.1080/07481180701603394.Peer-Reviewed Original Research
2006
PANDAS: to treat or not to treat?
King RA. PANDAS: to treat or not to treat? Advances In Neurology 2006, 99: 179-83. PMID: 16536364.Peer-Reviewed Original Research
2005
Regarding “Antibiotic Prophylaxis with Azithromycin or Penicillin for Childhood-Onset Neuropsychiatric Disorders”
Group T, Budman C, Coffey B, Dure L, Gilbert D, Juncos J, Kaplan E, King R, Kurlan R, Lowe T, Mack K, Mink J, Schlaggar B, Singer H. Regarding “Antibiotic Prophylaxis with Azithromycin or Penicillin for Childhood-Onset Neuropsychiatric Disorders”. Biological Psychiatry 2005, 58: 917. PMID: 16242121, DOI: 10.1016/j.biopsych.2005.08.005.Peer-Reviewed Original ResearchTourette’s Syndrome and Tic Disorders
Swain J, King R, Leckman J. Tourette’s Syndrome and Tic Disorders. Current Clinical Neurology 2005, 151-169. DOI: 10.1385/1-59259-856-0:151.Peer-Reviewed Original Research
2004
Obsessive-Compulsive Disorder in Tourette’s Syndrome
King R, Findley D, Scahill L, Vitulano L, Leckman J. Obsessive-Compulsive Disorder in Tourette’s Syndrome. Neurological Disease And Therapy 2004, 20046181: 427-453. DOI: 10.1201/b14236-22.Peer-Reviewed Original Research
2003
Suicide and the “continuum of adolescent self-destructiveness”: is there a connection?
King R, Ruchkin V, Schwab-Stone M. Suicide and the “continuum of adolescent self-destructiveness”: is there a connection? 2003, 41-62. DOI: 10.1017/cbo9780511550423.003.Peer-Reviewed Original Research