Case control and family‐based studies of tryptophan hydroxylase gene A218C polymorphism and suicidality in adolescents
Zalsman G, Frisch A, King R, Pauls D, Grice D, Gelernter J, Alsobrook J, Michaelovsky E, Apter A, Tyano S, Weizman A, Leckman J. Case control and family‐based studies of tryptophan hydroxylase gene A218C polymorphism and suicidality in adolescents. American Journal Of Medical Genetics 2001, 105: 451-457. PMID: 11449398, DOI: 10.1002/ajmg.1406.Peer-Reviewed Original ResearchConceptsSuicidal behaviorSuicide riskA218C polymorphismDetailed clinical historyHaplotype relative riskAssociation of suicidalityTransmission disequilibrium test (TDT) methodsTryptophan hydroxylase geneAdolescent suicidal behaviorClinical historySame ethnic populationRelative riskCase controlAA genotypeControl groupFamily-based studySuicide intentSignificant allelic associationSignificant differencesEthnic populationsStructured interviewsInpatient adolescentsRiskAssociationSuicidality