1992
Double-Blind, Crossover Trial of Fluoxetine and Placebo in Children and Adolescents with Obsessive-Compulsive Disorder
RIDDLE M, SCAHILL L, KING R, HARDIN M, ANDERSON G, ORT S, SMITH J, LECKMAN J, COHEN D. Double-Blind, Crossover Trial of Fluoxetine and Placebo in Children and Adolescents with Obsessive-Compulsive Disorder. Journal Of The American Academy Of Child & Adolescent Psychiatry 1992, 31: 1062-1069. PMID: 1429406, DOI: 10.1097/00004583-199211000-00011.Peer-Reviewed Original ResearchConceptsChildren's Yale-Brown Obsessive Compulsive ScaleObsessive-compulsive disorderYale-Brown Obsessive Compulsive ScaleEffective short-term treatmentSafety of fluoxetineFixed-dose trialCommon drug side effectsCY-BOCS total scoreMajor depressive disorderShort-term treatmentDrug side effectsMagnitude of improvementObsessive Compulsive ScaleFluoxetine groupPlacebo groupFluoxetine treatmentCrossover trialClinical trialsDepressive disorderObsessive-compulsive symptom severitySide effectsFluoxetineSymptom severityTotal scoreCompulsive Scale
1991
Emergence of Self-Destructive Phenomena in Children and Adolescents during Fluoxetine Treatment
KING R, RIDDLE M, CHAPPELL P, HARDIN M, ANDERSON G, LOMBROSO P, SCAHILL L. Emergence of Self-Destructive Phenomena in Children and Adolescents during Fluoxetine Treatment. Journal Of The American Academy Of Child & Adolescent Psychiatry 1991, 30: 179-186. PMID: 2016219, DOI: 10.1097/00004583-199103000-00003.Peer-Reviewed Original ResearchConceptsFluoxetine treatmentObsessive-compulsive disorderUniversity Clinical Research CenterClinical Research CenterMajor risk factorDrug-induced activationPrior suicidal ideationYounger patientsRisk factorsRegulation of aggressionPatientsSuicidal ideationSelf-destructive behaviorFluoxetineAge 10Apparent associationVulnerable individualsDisordersTreatmentIdeationDe novoHospitalizationSymptoms
1990
Fluoxetine Treatment of Children and Adolescents with Tourette's and Obsessive Compulsive Disorders: Preliminary Clinical Experience
RIDDLE M, HARDIN M, KING R, SCAHILL L, WOOLSTON J. Fluoxetine Treatment of Children and Adolescents with Tourette's and Obsessive Compulsive Disorders: Preliminary Clinical Experience. Journal Of The American Academy Of Child & Adolescent Psychiatry 1990, 29: 45-48. PMID: 2295577, DOI: 10.1097/00004583-199001000-00008.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderPreliminary clinical experiencePrimary obsessive-compulsive disorderTourette syndromeClinical experienceSelective serotonin uptake inhibitorMild gastrointestinal symptomsSerotonin uptake inhibitorEfficacy of fluoxetineCompulsive disorderFluoxetine administrationGastrointestinal symptomsFluoxetine treatmentResponder rateUptake inhibitorFluoxetineObsessive-compulsive symptomsPatientsAdverse effectsFluoxetine hydrochlorideSyndromeChildrenSymptomsOCD groupAdolescentsBehavioral Side Effects of Fluoxetine in Children and Adolescents
RIDDLE M, KING R, HARDIN M, SCAHILL L, ORT S, CHAPPELL P, RASMUSSON A, LECKMAN J. Behavioral Side Effects of Fluoxetine in Children and Adolescents. Journal Of Child And Adolescent Psychopharmacology 1990, 1: 193-198. DOI: 10.1089/cap.1990.1.193.Peer-Reviewed Original ResearchBehavioral side effectsSide effectsObsessive-compulsive symptomsExacerbation of symptomsCompulsive symptomsCommon psychopathological symptomsNeurological statusDosage reductionComplete resolutionSleep disturbancesMotor restlessnessLow dosesUnwanted symptomsFluoxetineSymptomsSubjective sensationPsychopathological symptomsLow dosageAge 8ChildrenDosesRestlessness