2023
Research objectives and general considerations for pragmatic clinical trials of pain treatments: IMMPACT statement
Hohenschurz-Schmidt D, Cherkin D, Rice A, Dworkin R, Turk D, McDermott M, Bair M, DeBar L, Edwards R, Farrar J, Kerns R, Markman J, Rowbotham M, Sherman K, Wasan A, Cowan P, Desjardins P, Ferguson M, Freeman R, Gewandter J, Gilron I, Grol-Prokopczyk H, Hertz S, Iyengar S, Kamp C, Karp B, Kleykamp B, Loeser J, Mackey S, Malamut R, McNicol E, Patel K, Sandbrink F, Schmader K, Simon L, Steiner D, Veasley C, Vollert J. Research objectives and general considerations for pragmatic clinical trials of pain treatments: IMMPACT statement. Pain 2023, 164: 1457-1472. PMID: 36943273, PMCID: PMC10281023, DOI: 10.1097/j.pain.0000000000002888.Peer-Reviewed Original ResearchMeSH KeywordsAnalgesicsConsensusHumansPainPain ManagementPragmatic Clinical Trials as TopicResearch DesignConceptsPragmatic trialPain treatmentClinical careSystematic reviewAddiction Clinical Trial TranslationsNetworks (ACTTION) public-private partnershipTraditional efficacy trialsRoutine clinical careDaily clinical carePragmatic clinical trialsEvidence-based treatmentsRelated health policiesInternal validityPain assessmentClinical managementClinical trialsEfficacy trialsConsensus meetingTrial designConsensus discussionTrial objectivesSuch trialsHealth policyTrialsExpert presentations
2022
Self-Management of Chronic Pain: Psychologically Guided Core Competencies for Providers
Kerns RD, Burgess DJ, Coleman BC, Cook CE, Farrokhi S, Fritz JM, Goertz C, Heapy A, Lisi AJ, Rhon DI, Vining R. Self-Management of Chronic Pain: Psychologically Guided Core Competencies for Providers. Pain Medicine 2022, 23: 1815-1819. PMID: 35642906, PMCID: PMC9629397, DOI: 10.1093/pm/pnac083.Peer-Reviewed Original ResearchIf you personalize it, will they use it?: Self-reported and observed use of a tailored, internet-based pain self-management program
Reuman L, Solar C, MacLean RR, Halat AM, Rajeevan H, Williams DA, Heapy AA, Bair MJ, Krein SL, Kerns RD, Higgins DM. If you personalize it, will they use it?: Self-reported and observed use of a tailored, internet-based pain self-management program. Translational Behavioral Medicine 2022, 12: 693-701. PMID: 35192703, PMCID: PMC9154266, DOI: 10.1093/tbm/ibab165.Peer-Reviewed Original ResearchMeSH KeywordsChronic PainHumansInternetInternet-Based InterventionPain ManagementSelf ReportSelf-ManagementEngaging Veterans and Military Service Members to Optimize Pragmatic Clinical Trials of Nonpharmacological Approaches for Pain Management
Anicich A, Katsovich L, Kerns RD. Engaging Veterans and Military Service Members to Optimize Pragmatic Clinical Trials of Nonpharmacological Approaches for Pain Management. Pain Medicine 2022, 23: pnac020-. PMID: 35143672, PMCID: PMC9425849, DOI: 10.1093/pm/pnac020.Peer-Reviewed Original ResearchTaking ACTION to Reduce Pain: a Randomized Clinical Trial of a Walking-Focused, Proactive Coaching Intervention for Black Patients with Chronic Musculoskeletal Pain
Burgess DJ, Hagel Campbell E, Hammett P, Allen KD, Fu SS, Heapy A, Kerns RD, Krein SL, Meis LA, Bangerter A, Cross LJS, Do T, Saenger M, Taylor BC. Taking ACTION to Reduce Pain: a Randomized Clinical Trial of a Walking-Focused, Proactive Coaching Intervention for Black Patients with Chronic Musculoskeletal Pain. Journal Of General Internal Medicine 2022, 37: 3585-3593. PMID: 35132545, PMCID: PMC9585120, DOI: 10.1007/s11606-021-07376-2.Peer-Reviewed Original ResearchConceptsBlack patientsUsual careSecondary outcomesPain intensityPrimary outcomeChronic painIntervention participantsVA health care systemMasked outcome assessmentChronic musculoskeletal painMental health comorbiditiesChronic pain outcomesAverage daily stepsTelephone coaching sessionsMain MeasuresPrimary outcomesCoaching interventionHealth care systemResultsThe interventionHealth comorbiditiesMusculoskeletal painPain outcomesSevere chronicPain interferenceGlobal ImpressionMeasuresPrimary outcomes
2021
Optimizing the Impact of Pragmatic Clinical Trials for Veteran and Military Populations: Lessons From the Pain Management Collaboratory
Ali J, Antonelli M, Bastian L, Becker W, Brandt CA, Burgess DJ, Burns A, Cohen SP, Davis AF, Dearth CL, Dziura J, Edwards R, Erdos J, Farrokhi S, Fritz J, Geda M, George SZ, Goertz C, Goodie J, Hastings SN, Heapy A, Ilfeld BM, Katsovich L, Kerns RD, Kyriakides TC, Lee A, Long CR, Luther SL, Martino S, Matheny ME, McGeary D, Midboe A, Pasquina P, Peduzzi P, Raffanello M, Rhon D, Rosen M, Esposito ER, Scarton D, Hastings SN, Seal K, Silliker N, Taylor S, Taylor SL, Tsui M, Wright FS, Zeliadt S. Optimizing the Impact of Pragmatic Clinical Trials for Veteran and Military Populations: Lessons From the Pain Management Collaboratory. Military Medicine 2021, 187: 179-185. PMID: 34791412, PMCID: PMC9389906, DOI: 10.1093/milmed/usab458.Peer-Reviewed Original ResearchMeSH KeywordsCOVID-19HumansMilitary PersonnelPain ManagementPandemicsPragmatic Clinical Trials as TopicResearch DesignVeteransConceptsPragmatic clinical trialsPain Management CollaboratoryClinical trialsMultisite pragmatic clinical trialManagement of painDual public health crisesCommon co-occurring conditionsPragmatic trial designUnmet healthcare needsMilitary Health SystemCo-occurring conditionsPublic health crisisPain managementChronic painNonpharmacological approachesOpioid misuseMultifactorial etiologyTrial designVeterans AffairsMilitary populationHealthcare needsHealth systemNational InstitutePainCOVID-19 pandemicCorrelates of Manual Therapy and Acupuncture Use Among Rural Patients Seeking Conventional Pain Management: A Cross-sectional Study
Feinberg TM, Coleman B, Innes KE, Kerns RD, Jackson B, Lisi A, Majoris N, Brandt C. Correlates of Manual Therapy and Acupuncture Use Among Rural Patients Seeking Conventional Pain Management: A Cross-sectional Study. Journal Of Manipulative And Physiological Therapeutics 2021, 44: 330-343. PMID: 33896602, DOI: 10.1016/j.jmpt.2021.01.002.Peer-Reviewed Original ResearchConceptsComplementary health approachesManual therapyCross-sectional studyPain managementAcupuncture useHealth approachAge-adjusted logistic regressionConventional pain managementCurrent chronic painHigh pain burdenPrior opioid usePain scale scoresMind-body therapiesHealth-related factorsPain-related distressPain burdenOpioid useRheumatology clinicChronic painClinical outcomesPain carePain distressRural patientsMajority of participantsPrescription medicationsDevelopment and Implementation of the Military Treatment Facility Engagement Committee (MTFEC) to Support Pragmatic Clinical Trials in the Military Health System
Scarton DV, Roddy WT, Taylor JA, Geda M, Brandt CA, Peduzzi P, Kerns RD, Pasquina PF. Development and Implementation of the Military Treatment Facility Engagement Committee (MTFEC) to Support Pragmatic Clinical Trials in the Military Health System. Military Medicine 2021, 186: 70-75. PMID: 33499543, PMCID: PMC7980475, DOI: 10.1093/milmed/usaa368.Peer-Reviewed Original ResearchMeSH KeywordsChronic PainHumansMilitary Health ServicesPain ManagementUnited StatesUnited States Department of Veterans AffairsVeteransConceptsPain Management CollaboratoryPragmatic clinical trialsMilitary treatment facilitiesHealth care systemPain managementClinical trialsDOD health care systemVA health care systemCare systemChronic pain managementService membersTraumatic brain injuryMilitary Health SystemMilitary service membersChronic painNonpharmacological approachesBrain injuryLimb lossClinical practiceHealth systemCoordinating CenterTrialsVA programsNational InstituteDepartment of Defense
2020
Strategy for addressing research-site overlap in pragmatic clinical trials: lessons learned from the NIH-DOD-VA Pain Management Collaboratory (PMC)
Geda M, George SZ, Burgess DJ, Scarton DV, Roddy WT, Gordon KS, Pasquina PF, Brandt CA, Kerns RD, Peduzzi P. Strategy for addressing research-site overlap in pragmatic clinical trials: lessons learned from the NIH-DOD-VA Pain Management Collaboratory (PMC). Trials 2020, 21: 1021. PMID: 33308289, PMCID: PMC7731473, DOI: 10.1186/s13063-020-04941-8.Peer-Reviewed Original ResearchMeSH KeywordsDelivery of Health CareHumansNational Institutes of Health (U.S.)Pain ManagementUnited StatesConceptsPain Management CollaboratoryPragmatic clinical trialsVA Medical CenterMilitary treatment facilitiesClinical trialsExclusion criteriaVeterans AffairsHealth care systemPain managementNonpharmacological approachesPragmatic trialMedical CenterEligibility criteriaTrial settingsTrial integrityCare systemNational InstituteTrialsRecruitment methodsRecruitment strategiesRecruitment planRecruitment sitesDesigning Trials with Purpose: Pragmatic Clinical Trials of Nonpharmacological Approaches for Pain Management
Gordon KS, Peduzzi P, Kerns RD. Designing Trials with Purpose: Pragmatic Clinical Trials of Nonpharmacological Approaches for Pain Management. Pain Medicine 2020, 21: s7-s12. PMID: 33313727, PMCID: PMC7825099, DOI: 10.1093/pm/pnaa347.Peer-Reviewed Original ResearchConceptsPragmatic clinical trialsPatient-centered outcomesPain managementNonpharmacological approachesPRECIS-2 domainsClinical trialsFuture pragmatic clinical trialsImportant patient-centered outcomesPragmatic-Explanatory Continuum Indicator SummaryNonpharmacological pain managementPain care planManagement of painCommon co-occurring conditionsRoutine clinical practiceCo-occurring conditionsDesigning TrialsUsual careCare plansClinical practiceSignificant causeTrialsPainOutcomesFuture investigatorsManagementStakeholder Engagement in Pragmatic Clinical Trials: Emphasizing Relationships to Improve Pain Management Delivery and Outcomes
Bastian LA, Cohen SP, Katsovich L, Becker WC, Brummett BR, Burgess DJ, Crunkhorn AE, Denneson LM, Frank JW, Goertz C, Ilfeld B, Kanzler KE, Krishnaswamy A, LaChappelle K, Martino S, Mattocks K, McGeary CA, Reznik TE, Rhon DI, Salsbury SA, Seal KH, Semiatin AM, Shin MH, Simon CB, Teyhen DS, Zamora K, Kerns RD, Collaboratory T. Stakeholder Engagement in Pragmatic Clinical Trials: Emphasizing Relationships to Improve Pain Management Delivery and Outcomes. Pain Medicine 2020, 21: s13-s20. PMID: 33313726, PMCID: PMC7824996, DOI: 10.1093/pm/pnaa333.Peer-Reviewed Original ResearchConceptsPragmatic clinical trialsPain Management CollaboratoryTarget treatment populationClinical trialsManagement of painPrimary care cliniciansHealth care teamCo-occurring conditionsMilitary service membersCare cliniciansNonpharmacological approachesPragmatic trialCare teamPain researchHealth system leadersTreatment populationTrial researchersCoordinating CenterHealth OrganizationTrialsService membersPainPrincipal investigatorManagement deliveryGroupNIH-DOD-VA Pain Management Collaboratory: Pragmatic Clinical Trials of Nonpharmacological Approaches for Management of Pain and Co-occurring Conditions in Veteran and Military Health Systems: Introduction
Kerns RD, Brandt CA. NIH-DOD-VA Pain Management Collaboratory: Pragmatic Clinical Trials of Nonpharmacological Approaches for Management of Pain and Co-occurring Conditions in Veteran and Military Health Systems: Introduction. Pain Medicine 2020, 21: s1-s4. PMID: 33313722, DOI: 10.1093/pm/pnaa358.Peer-Reviewed Original ResearchMeSH KeywordsHumansMilitary Health ServicesPainPain ManagementUnited StatesUnited States Department of Veterans AffairsVeteransPivoting to virtual delivery for managing chronic pain with nonpharmacological treatments: implications for pragmatic research
Fritz JM, Davis AF, Burgess DJ, Coleman B, Cook C, Farrokhi S, Goertz C, Heapy A, Lisi AJ, McGeary DD, Rhon DI, Taylor SL, Zeliadt S, Kerns RD. Pivoting to virtual delivery for managing chronic pain with nonpharmacological treatments: implications for pragmatic research. Pain 2020, 162: 1591-1596. PMID: 33156148, PMCID: PMC8089114, DOI: 10.1097/j.pain.0000000000002139.Peer-Reviewed Original ResearchAdapting to disruption of research during the COVID-19 pandemic while testing nonpharmacological approaches to pain management
Coleman BC, Kean J, Brandt CA, Peduzzi P, Kerns RD, . Adapting to disruption of research during the COVID-19 pandemic while testing nonpharmacological approaches to pain management. Translational Behavioral Medicine 2020, 10: 827-834. PMID: 32885815, PMCID: PMC7499692, DOI: 10.1093/tbm/ibaa074.Peer-Reviewed Original ResearchMeSH KeywordsBetacoronavirusChronic PainCommunicable Disease ControlCoronavirus InfectionsCOVID-19HumansMental HealthNational Institutes of Health (U.S.)Pain ManagementPandemicsPatient SelectionPneumonia, ViralResearchSARS-CoV-2Socioeconomic FactorsUnited StatesUnited States Department of Veterans AffairsConceptsPain Management CollaboratoryPragmatic clinical trialsChronic painCOVID-19 pandemicUrgent public health challengePain management interventionsClinical care teamPatient-reported measuresPublic health challengeVeterans Health SystemCOVID-19Pain managementNonpharmacological approachesStudy protocolClinical trialsCare teamIntervention deliveryHealth departmentsHealth outcomesHealth challengesHealth systemStudy designMental healthDisruption of researchParticipant recruitment“Asking Is Never Bad, I Would Venture on That”: Patients’ Perspectives on Routine Pain Screening in VA Primary Care
Giannitrapani KF, Haverfield MC, Lo NK, McCaa MD, Timko C, Dobscha SK, Kerns RD, Lorenz KA. “Asking Is Never Bad, I Would Venture on That”: Patients’ Perspectives on Routine Pain Screening in VA Primary Care. Pain Medicine 2020, 21: 2163-2171. PMID: 32142132, DOI: 10.1093/pm/pnaa016.Peer-Reviewed Original ResearchConceptsPain screeningPrimary carePatient's perspectiveVA health care systemPain management strategiesVA primary careVeterans Health AdministrationMental health concernsHealth care systemRoutine carePatient recallPatients' perceptionsPatient recommendationsPainRoutine painHealth AdministrationHealth concernCare systemMental distressCarePatientsPsychological painScreeningTheme 1Theme 2Internet‐Based Pain Self‐Management for Veterans: Feasibility and Preliminary Efficacy of the Pain EASE Program
Higgins DM, Buta E, Williams DA, Halat A, Bair MJ, Heapy AA, Krein SL, Rajeevan H, Rosen MI, Kerns RD. Internet‐Based Pain Self‐Management for Veterans: Feasibility and Preliminary Efficacy of the Pain EASE Program. Pain Practice 2020, 20: 357-370. PMID: 31778281, DOI: 10.1111/papr.12861.Peer-Reviewed Original ResearchConceptsChronic low back painSelf-management programPain interferencePreliminary efficacyInternet-based self-management programPhase IPost-baseline assessmentLow back painPain Self-ManagementPhase IIPreliminary efficacy studyTechnology-delivered interventionsModerate painSecondary outcomesPain intensityBack painAverage ageEfficacy studiesDepression symptomsSubject improvementExpert panelSelf-ManagementSubject changesEASE programWeeks
2019
Further Examination of the Pain Stages of Change Questionnaires Among Chronic Low Back Pain Patients
Mun CJ, Otis JD, Concato J, Reid MC, Burg MM, Czlapinski R, Kerns RD. Further Examination of the Pain Stages of Change Questionnaires Among Chronic Low Back Pain Patients. The Clinical Journal Of Pain 2019, 35: 744-752. PMID: 31149934, DOI: 10.1097/ajp.0000000000000733.Peer-Reviewed Original ResearchConceptsChronic low back pain patientsLow back pain patientsSelf-management approachBack pain patientsCognitive behavioral therapyChronic painDepressive symptom severityPain severityPain patientsPain StagesRegular cognitive behavioural therapySymptom severityVA primary care clinicsChange scoresPrimary care clinicsChange QuestionnaireLong-term functionMaintenance scoresCare clinicsPresent studyPatient readinessPatients' attitudesWeeks posttreatmentSustained benefitTherapeutic mechanismNIH-DoD-VA Pain Management Collaboratory
Kerns RD, Brandt CA, Peduzzi P. NIH-DoD-VA Pain Management Collaboratory. Pain Medicine 2019, 20: 2336-2345. PMID: 31807788, PMCID: PMC6895460, DOI: 10.1093/pm/pnz186.Peer-Reviewed Original ResearchEngaging Mental Health Professionals in Addressing Pain
Edmond SN, Heapy AA, Kerns RD. Engaging Mental Health Professionals in Addressing Pain. JAMA Psychiatry 2019, 76: 565-566. PMID: 30942829, DOI: 10.1001/jamapsychiatry.2019.0254.Peer-Reviewed Original ResearchCore Competencies for the Emerging Specialty of Pain Psychology
Wandner LD, Prasad R, Ramezani A, Malcore SA, Kerns RD. Core Competencies for the Emerging Specialty of Pain Psychology. American Psychologist 2019, 74: 432-444. PMID: 30070541, DOI: 10.1037/amp0000330.Peer-Reviewed Original ResearchConceptsNational Pain StrategyPain managementInstitute of MedicinePain psychologistPain strategiesChronic painPain carePain psychologyPainField of psychologyIOM reportCore competenciesSpecialty areasPsychologistsHuman ServicesPivotal rolePsychologyMultiple professionsEmerging SpecialtySpecialtiesCurrent articleManagementCliniciansCare