2024
Higher prevalence of kidney function impairment among older people living with HIV in Uganda
Ssemasaazi A, Kalyesubula R, Manabe Y, Mbabazi P, Naikooba S, Ssekindi F, Nasuuna E, Byakika-Kibwika P, Castelnuovo B. Higher prevalence of kidney function impairment among older people living with HIV in Uganda. BMC Nephrology 2024, 25: 321. PMID: 39334034, PMCID: PMC11428404, DOI: 10.1186/s12882-024-03761-1.Peer-Reviewed Original ResearchConceptsKidney function impairmentChronic kidney diseaseAntiretroviral therapyOlder PLWHFunctional impairmentKidney functionKidney diseaseHIV-related inflammationProgression of kidney diseasePrevalence of proteinuriaMultivariate logistic regression modelBurden of chronic kidney diseaseMeasures of kidney functionDiagnosis of hypertensionCross-sectional studyConclusionsHIV infectionHIV-related clinical characteristicsClinical characteristicsInstitution of measuresLogistic regression modelsDiabetes mellitusFemale sexHIVProteinuriaPLWHIncidence of Acute Kidney Injury and Associated Mortality among Individuals with Drug-Susceptible Tuberculosis in Uganda
Kansiime G, Aklilu A, Baluku J, Yasmin F, Kanyesigye M, Muzoora C, Wilson F, Bajunirwe F, Brewster U, Kalyesubula R. Incidence of Acute Kidney Injury and Associated Mortality among Individuals with Drug-Susceptible Tuberculosis in Uganda. Kidney360 2024, 5: 1446-1454. PMID: 39141693, PMCID: PMC11556924, DOI: 10.34067/kid.0000000000000551.Peer-Reviewed Original ResearchIncidence of acute kidney injuryAcute kidney injuryDiagnosis periodKidney injuryKDIGO-defined acute kidney injuryKidney functionTB diagnosisPredictors of acute kidney injuryTime to TB diagnosisAssociated with significant risk of mortalityIndependent of HIV statusOverall incidence of AKIAssociated with increased mortality riskCohort study of adultsAssociated with higher oddsAssociated with significant mortalityDrug-susceptible TBDrug-susceptible tuberculosisObservational cohort study of adultsAssociated with significant riskHIV-negative participantsSignificant risk of mortalityObservational cohort studyStudy of adultsMonitoring kidney function
2023
HIV and Associated TB: A Lethal Association for Kidney Health?
Kalyesubula R, Wearne N, Kubo M, Hussey N, Naicker S. HIV and Associated TB: A Lethal Association for Kidney Health? Seminars In Nephrology 2023, 43: 151470. PMID: 38245391, DOI: 10.1016/j.semnephrol.2023.151470.Peer-Reviewed Original ResearchHuman immunodeficiency virusKidney diseaseHIV/TB coinfectionAvoidance of drug-drug interactionsLower-middle-income countriesDrug dose adjustmentDecline of kidney functionKidney function monitoringDrug-drug interactionsMechanisms of kidney diseasesHIV/TB patientsLow-incomeDose adjustmentImmunodeficiency virusClinical presentationDiagnose CKDKidney transplantationKidney functionInfectious causesIncreased riskKidney healthGenetic susceptibilityFunction monitoringPatientsKidney