Comparison of the prevalence and associated factors of chronic kidney disease diagnosed by serum creatinine or cystatin C among young people living with HIV in Uganda
Nasuuna E, Tomlinson L, Kalyesubula R, Dziva Chikwari C, Castelnuovo B, Manabe Y, Nakanjako D, Weiss H. Comparison of the prevalence and associated factors of chronic kidney disease diagnosed by serum creatinine or cystatin C among young people living with HIV in Uganda. BMC Nephrology 2024, 25: 422. PMID: 39587464, PMCID: PMC11590532, DOI: 10.1186/s12882-024-03865-8.Peer-Reviewed Original ResearchConceptsAlbumin-creatinine ratioChronic kidney diseaseFactors associated with chronic kidney diseaseSerum creatinineAdjusted odds ratiosCystatin CKidney diseaseEarly diagnosisAssociated with chronic kidney diseasePrevalence of chronic kidney diseaseCompare serum creatinineCreatinine-based onesFactors of chronic kidney diseaseAssociated with high mortalityCases of chronic kidney diseaseDefinition of chronic kidney diseaseChronic kidney disease prevalenceCystatin C-based equationsCystatin C levelsEstimate adjusted odds ratiosMeasuring urinary albuminConfidence intervalsDiagnosis of chronic kidney diseaseMultivariate logistic regressionReduce disease progressionPrevalence of chronic kidney disease among young people living with HIV in Sub Saharan Africa: A systematic review and meta-analysis
Nasuuna E, Nanyeenya N, Kibirige D, Izudi J, Chikwari C, Kalyesubula R, Castelnuovo B, Tomlinson L, Weiss H. Prevalence of chronic kidney disease among young people living with HIV in Sub Saharan Africa: A systematic review and meta-analysis. PLOS ONE 2024, 19: e0301954. PMID: 39495780, PMCID: PMC11534254, DOI: 10.1371/journal.pone.0301954.Peer-Reviewed Original ResearchConceptsPrevalence of chronic kidney diseaseChronic kidney disease prevalenceCKD prevalenceSub-Saharan AfricaDefinition of chronic kidney diseaseChronic kidney diseaseMeta-analysisPublication biasGlomerular filtration rateSystematic reviewJoanna Briggs Institute checklistEligibility criteriaI-squared valuePooled prevalence of chronic kidney diseaseEstimates of CKD prevalenceAlbumin-to-creatinine ratioDerSimonian-Laird random-effects modelCross-sectional studyRisk of biasAfrican Journals OnlineAfrican Index MedicusCochran's Q testRandom-effects modelStandard definitionYoung peopleHigher prevalence of kidney function impairment among older people living with HIV in Uganda
Ssemasaazi A, Kalyesubula R, Manabe Y, Mbabazi P, Naikooba S, Ssekindi F, Nasuuna E, Byakika-Kibwika P, Castelnuovo B. Higher prevalence of kidney function impairment among older people living with HIV in Uganda. BMC Nephrology 2024, 25: 321. PMID: 39334034, PMCID: PMC11428404, DOI: 10.1186/s12882-024-03761-1.Peer-Reviewed Original ResearchConceptsKidney function impairmentChronic kidney diseaseAntiretroviral therapyOlder PLWHFunctional impairmentKidney functionKidney diseaseHIV-related inflammationProgression of kidney diseasePrevalence of proteinuriaMultivariate logistic regression modelBurden of chronic kidney diseaseMeasures of kidney functionDiagnosis of hypertensionCross-sectional studyConclusionsHIV infectionHIV-related clinical characteristicsClinical characteristicsInstitution of measuresLogistic regression modelsDiabetes mellitusFemale sexHIVProteinuriaPLWHDiagnostic performance of an albuminuria point-of-care test in screening for chronic kidney disease among young people living with HIV in Uganda: a cross-sectional study
Nasuuna E, Kalyesubula R, Tomlinson L, Castelnuovo B, Okello E, Chikwari C, Weiss H. Diagnostic performance of an albuminuria point-of-care test in screening for chronic kidney disease among young people living with HIV in Uganda: a cross-sectional study. BMJ Open 2024, 14: e083221. PMID: 39153770, PMCID: PMC11331864, DOI: 10.1136/bmjopen-2023-083221.Peer-Reviewed Original ResearchConceptsPositive POC testCross-sectional studyChronic kidney diseaseDiagnostic performancePoint-of-care testingKidney diseaseHIV clinicPOC testingPOC testsBody mass index <Albumin-creatinine ratioPositive predictive valueUrinary excretion rateDiagnosis of chronic kidney diseaseYoung peopleYears of ageTherapy to adultsYPLHIVUrine dipstickCreatinine ratioDiagnosis of albuminuriaLogistic regressionPrimary outcomeAlbuminuriaHIVThe Future of Kidney Care in Low- and Middle-Income Countries: Challenges, Triumphs, and Opportunities
Kalyesubula R, Aklilu A, Calice-Silva V, Kumar V, Kansiime G. The Future of Kidney Care in Low- and Middle-Income Countries: Challenges, Triumphs, and Opportunities. Kidney360 2024, 5: 1047-1061. PMID: 38922683, PMCID: PMC11296549, DOI: 10.34067/kid.0000000000000489.Peer-Reviewed Original ResearchKidney careMiddle-income countriesHealth system infrastructureResilient health care systemHealth care providersKidney healthHealth care systemChronic kidney diseaseCare providersUnique risk factorsHealth priorityCare systemLack of awarenessChronic diseasesGeneral populationCareLMICsKidney replacement therapyHealthRisk factorsGenetic predispositionEarly detectionMultidisciplinary followFinancing mechanismsHuman resourcesCapacity for the management of kidney failure in the International Society of Nephrology Africa region: report from the 2023 ISN Global Kidney Atlas (ISN-GKHA)
Tannor E, Davidson B, Nlandu Y, Bagasha P, Bilchut W, Davids M, Diongole H, Ekrikpo U, Hafiz E, Ibrahim K, Kalyesubula R, Nalado A, Olanrewaju T, Onu U, Pereira-Kamath N, Sakajiki A, Salah M, Vincent L, Arruebo S, Bello A, Caskey F, Damster S, Donner J, Jha V, Johnson D, Levin A, Malik C, Nangaku M, Okpechi I, Tonelli M, Ye F, Ashuntantang G, Arogundade F, Authors R, Gawad M, Abderrahim E, Akl A, Amekoudi E, Amouzegar A, Awobusuyi J, Bakoush O, Chissico E, Cho Y, Coker J, Cullis B, Dahwa R, Darwish R, Davison S, Divyaveer S, Ethier I, Fagoonee K, Fofana A, Freercks R, Fung W, Gandzali-Ngabe P, Ghimire A, Gouda Z, Habyarimana O, Htay H, Wan D, Irish G, Ismail W, Jagne A, Jarraya F, Jindal K, Kabllo B, Kalebi A, Folefack F, Kelly D, Lalji R, Lomatayo B, Mah S, Abderraman G, McCulloch M, Mengistu Y, Moloi M, Mwaba C, Neuen B, Ngigi J, Niang A, Nyandwi J, Odeh E, Osman M, Le Grand Ouanekpone C, Petrova A, Ranivoharisoa E, Riaz P, Saad S, See E, Sokwala A, Solarin A, Sozio S, Houssani T, Kiswaya E, Tia W, Tiv S, Ts'enoli T, Tungsanga S, Ulasi I, Vanglist S, Viecelli A, Wadee S, Wainstein M, Wearne N, Yeung E, Zaidi D. Capacity for the management of kidney failure in the International Society of Nephrology Africa region: report from the 2023 ISN Global Kidney Atlas (ISN-GKHA). Kidney International Supplements 2024, 13: 12-28. PMID: 38618494, PMCID: PMC11010621, DOI: 10.1016/j.kisu.2024.01.002.Peer-Reviewed Original ResearchHealth care workforceManagement of peopleCare workforceHealth systemKidney careWorld Health Organization building blocksIncreased out-of-pocket costsChronic kidney disease preventionGlobal Kidney Health AtlasBurden of chronic kidney diseaseOut-of-pocket costsKidney disease preventionHealth information dataHealth care workersChronic kidney diseaseManagement of kidney failureCare deliveryKidney disease managementNondialysis chronic kidney diseaseCare workersCare financingHealth infrastructureDisease preventionService deliveryKidney disease