Targeted lung expression of interleukin-11 enhances murine tolerance of 100% oxygen and diminishes hyperoxia-induced DNA fragmentation.
Waxman AB, Einarsson O, Seres T, Knickelbein RG, Warshaw JB, Johnston R, Homer RJ, Elias JA. Targeted lung expression of interleukin-11 enhances murine tolerance of 100% oxygen and diminishes hyperoxia-induced DNA fragmentation. Journal Of Clinical Investigation 1998, 101: 1970-1982. PMID: 9576762, PMCID: PMC508784, DOI: 10.1172/jci1337.Peer-Reviewed Original ResearchConceptsIL-11Lung injuryTransgene (-) animalsIL-1Alveolar-capillary protein leakPulmonary neutrophil recruitmentAcute lung injuryHyperoxic gas mixtureDNA fragmentationLevels of totalMurine toleranceLung expressionNeutrophil recruitmentProtein leakTNF productionLung antioxidantsTransgenic miceCopper-zinc superoxide dismutaseZinc superoxide dismutaseHyperoxiaGlutathione peroxidaseLipid peroxidationInjuryOxygen toxicityDismutase activity