Cutting Edge: Engagement of NKG2A on CD8+ Effector T Cells Limits Immunopathology in Influenza Pneumonia
Zhou J, Matsuoka M, Cantor H, Homer R, Enelow RI. Cutting Edge: Engagement of NKG2A on CD8+ Effector T Cells Limits Immunopathology in Influenza Pneumonia. The Journal Of Immunology 2008, 180: 25-29. PMID: 18096998, DOI: 10.4049/jimmunol.180.1.25.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigensCD8-Positive T-LymphocytesHistocompatibility Antigens Class IInfluenza A virusMiceMice, Inbred BALB CMice, Inbred C57BLNK Cell Lectin-Like Receptor Subfamily CNK Cell Lectin-Like Receptor Subfamily DOrthomyxoviridae InfectionsPneumonia, ViralReceptors, ImmunologicReceptors, Natural Killer CellConceptsInfluenza pneumoniaT cellsLung injuryTNF productionT cell-mediated clearanceQa-1bAg-specific CD8Considerable lung injurySevere influenza infectionCD94/NKG2AT cell Ag recognitionEffector cell recognitionLimit immunopathologyNKG2A blockadeAntiviral CD8Distal airwaysInfluenza infectionPulmonary pathologyTNF-alphaCD8Infectious virusAg recognitionImmunopathologyPneumoniaCell recognition